DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nc73EF and CG1544

DIOPT Version :9

Sequence 1:	NP_001097629.1	Gene:	Nc73EF / 39899	FlyBaseID:	FBgn0010352	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_651849.1	Gene:	CG1544 / 43689	FlyBaseID:	FBgn0039827	Length:	919	Species:	Drosophila melanogaster

Alignment Length:	873	Identity:	311/873 - (35%)
Similarity:	491/873 - (56%)	Gaps:	87/873 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 VQAIIRSYQIRGHNIAHLDPLEINTPELPGNSSTKSIYANFSFGEQDMDRQFKLPSTTFIGGDEA 194
            |...:.:::..||.:|.::|:.|.|.:......:.:.|.        :..|..:.:...:.|.:.
  Fly    56 VYRFVEAFRQHGHKLAAVNPISIRTSQQELQELSPAFYG--------LQTQEPVRTDGLLSGPQV 112

  Fly   195 SLPLKEILNRLENVYCNK-IGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEKRLILARLTRATG 258
            :..:.::...|:::||.: ...||.::..:|:..|:.:.|||.........|:..|...|.::..
  Fly   113 AHNVAQLEQLLKDIYCGRSTSAEFSYVEDIEEREWLARNFETLDQQQLGKSERCEIAELLIKSQA 177

  Fly   259 FEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLNTLANVCRKPLNQ 323
            ::.|:|.|:.:.||:|.||.|.|:....:::..|.:..:|.|::.||||||....|.:......:
  Fly   178 WDNFMALKFPTVKRYGGEGAESMLAFFWQLLRDSVQANIEHVVLAMPHRGRTPLQAALLNMRPAK 242

  Fly   324 IFTQFAGL-EAADD--GSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVDPVVQGKTRAE 385
            :|.:.:|. |.::|  ...||..|.  ::....::..|.:..::|.|||||||.:||..||||::
  Fly   243 VFRKLSGASEFSEDIEAMSDVISHF--HVSEQLKILGKKLSFSMVRNPSHLEAANPVAMGKTRSK 305

  Fly   386 QFYRGDQE--------GKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVVANNQIGF 442
            |..||:..        |:.|:::::||||||.|||:..|.::::.:|.:...|::|::.|||:||
  Fly   306 QQARGEGAFGDGSQPFGEHVLNVILHGDAAFAGQGINQECLNMAYVPHFEVGGSLHLIVNNQVGF 370

  Fly   443 TTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRNGH 507
            ||.....||:.|.:|:|:.:.||:||||.|||||:..|..:|..::..|.||..|||..:||.||
  Fly   371 TTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEALARVTSLAFRYQREFRKDIFIDLNCFRRWGH 435

  Fly   508 NEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTETH 572
            ||:|:|.||.||:|:.:.:.::..||||.:|..|..::..:.|.:..:|.....|..|||..
  Fly   436 NELDDPTFTNPLVYKIVHQRESVPDLYAQQLAKEQVLSESKAKEMRDEYMKYLGEELALAPA--- 497

  Fly   573 VKYK---DWLDSPWSGFFEGKDPLKVAP--------TGVKEETLIHIGNRFSSPPPNAAEFVIHK 626
              |:   .:.:..|:.|       ::||        ||:....|.:||.:..:.|   .:|.||.
  Fly   498 --YQPPPSYFEKQWTNF-------QLAPSKELTYWDTGLDYSLLHYIGQQSVTFP---EDFNIHP 550

  Fly   627 GLLR--VLAARKAMVDEKVADWALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVD 689
            .||:  |.|..|.:.:....||:..||:|.|||:.:|.:||:||:||.||||||||.:    |||
  Fly   551 HLLKTHVNARLKKLENGVKIDWSTAEALAIGSLMYQGHNVRISGEDVGRGTFSHRHAM----LVD 611

  Fly   690 KAT------YNSLQHMYPDQAPYSVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQ 748
            :.|      .||::.  .:.....:::|.|||.||||||:|.::.|||.|::||||||||:|.||
  Fly   612 QQTNEMFIPLNSMEG--GNGGKLELAHSILSEEAVLGFEYGMAIDNPNNLIIWEAQFGDFANGAQ 674

  Fly   749 SIIDQFISSGQSKWVRQSGLVMLLPHGMEGMGPEHSSCRVERFLQM-----SSDDPDYFPPESDE 808
            .|||.||.||::||:..:.||||||||.:|...||||||:|||||:     :|.|.|
  Fly   675 IIIDTFIVSGETKWMESNALVMLLPHGYDGAASEHSSCRIERFLQLCDSKETSADGD-------- 731

  Fly   809 FGVRQLHDINWIVANCSTPANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEF 873
                   .:|..:.|.:|||.|||:||||:|..|||||::..||:|||.|.|.|...:...|:.|
  Fly   732 -------SVNVHIVNPTTPAQYYHVLRRQLARNFRKPLVVVAPKTLLRLPAATSTHEDFQPGTLF 789

  Fly   874 QRIIPDNGPAGQNPSNVKKVVFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQAN 938
            ..::   |.....|..|:||:.|||:.||.|.: .|||:...:.||:|:|.:.|||...::.|..
  Fly   790 HNVL---GDTIAKPEQVRKVILCSGKHYYTLAE-EREKRQAYDTAILRLESLCPFPIQELQAQLA 850

  Fly   939 LYKNAE-LVWAQEEHKNQGSWTYVQPRF 965
            .|.|.: .||:||||:|.|:||:|:|||
  Fly   851 QYGNVQSFVWSQEEHRNMGAWTFVRPRF 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696
		sucA	53..1104	CDD:236499	311/873 (36%)
		TPP_E1_OGDC_like	259..521	CDD:238974	103/272 (38%)
		Transket_pyr	645..856	CDD:280874	108/221 (49%)
		OxoGdeHyase_C	863..1102	CDD:293475	40/104 (38%)
CG1544	NP_651849.1	sucA	35..918	CDD:236499	311/873 (36%)
		TPP_E1_OGDC_like	178..449	CDD:238974	103/272 (38%)
		Transket_pyr	569..772	CDD:280874	108/223 (48%)
		OxoGdeHyase_C	779..917	CDD:293475	40/104 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.650