DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nc73EF and Ogdh

DIOPT Version :9

Sequence 1:	NP_001097629.1	Gene:	Nc73EF / 39899	FlyBaseID:	FBgn0010352	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_038948146.1	Gene:	Ogdh / 360975	RGDID:	1561359	Length:	1038	Species:	Rattus norvegicus

Alignment Length:	1121	Identity:	619/1121 - (55%)
Similarity:	765/1121 - (68%)	Gaps:	133/1121 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSPMAHKNFATWLLKSSSSQQMAKVTAAAAVRTYNS-AAAEPFANGSTASYVEEMYNAWLRDPTS 75
            |.|:.    |:..:|:.|..:.|.:.....:|.|:: .|||||.:|::::||||||.|||.:|.|
  Rat    11 LRPLT----ASQTVKTFSQNKPAAIRTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKS 71

  Fly    76 VHTSWDAYFRSNSYVSPPNLA---PVQANTLPLTAFNFGGAVAGAAPD-SKTIDDHLAVQAIIRS 136
            ||.|||.:||:.:..:||..|   |:..:...|.......::..|.|: .|.::||||||::||:
  Rat    72 VHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVEAQPNVDKLVEDHLAVQSLIRA 136

  Fly   137 YQIRGHNIAHLDPLEINTPELPGN------SSTK--------------SIYANFSFGEQDMDRQF 181
            ||||||::|.||||.|...:|..:      |||.              ::...:...|.|:|:.|
  Rat   137 YQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLHESDLDKVF 201

  Fly   182 KLPSTTFIGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEK 246
            .||:||||||.|.:|||:||:.|||..||..|||||||||.||||.|||::|||||::.|:.|||
  Rat   202 HLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEK 266

  Fly   247 RLILARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLN 311
            |.:||||.|:|.||.||.:|:||||||||||||::|||||.|||:|:..||:.||||||||||||
  Rat   267 RTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDMSSANGVDYVIMGMPHRGRLN 331

  Fly   312 TLANVCRKPLNQIFTQF-AGLEAADDGSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVD 375
            .||||.||.|.|||.|| :.|||||:||||:|||||.|..|:||||::||.|::|||||||||.|
  Rat   332 VLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYHRRINRVTDRNITLSLVANPSHLEAAD 396

  Fly   376 PVVQGKTRAEQFYRGDQEGKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVVANNQI 440
            |||.|||:|||||.||.|||||||||:||||||.|||:||||.||||||.||||||:|||.||||
  Rat   397 PVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQI 461

  Fly   441 GFTTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRN 505
            |||||||.:|||||.|||||||||||||||:|||||||:|||||||||.|||||.|:|||.||||
  Rat   462 GFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRN 526

  Fly   506 GHNEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTE 570
            ||||:|||||||||||::|||.|..|..||:.|:::|.|...|.:...:||:.||||||..:|.|
  Rat   527 GHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDE 591

  Fly   571 THVKYKDWLDSPWSGFF--EGKDPLKVAP-TGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVL 632
            ..:..|.||||||.|||  :|:......| ||::|:.|.||||..||.|  ...|.||.||.|:|
  Rat   592 KILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLEEDILTHIGNVASSVP--VENFTIHGGLSRIL 654

  Fly   633 AARKAMVDEKVADWALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQ 697
            ..|:.:|..:..||||.|.|||||||||||||||||||||||||||||||||.|.|||.|...:.
  Rat   655 KTRRELVTNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMN 719

  Fly   698 HMYPDQAPYSVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKW 762
            |::|:||||:|.|||||||.|||||.|::|.:||||||||||||||:|.||.||||||..||:||
  Rat   720 HLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKW 784

  Fly   763 VRQSGLVMLLPHGMEGMGPEHSSCRVERFLQMSSDDPDYFPP-ESDEFGVRQLHDINWIVANCST 826
            |||:|:|:|||||||||||||||.|.||||||.:||||..|. :.:.|.:.||:|.||||.||||
  Rat   785 VRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPNLQEENFDISQLYDCNWIVVNCST 849

  Fly   827 PANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGPAGQNPSNVK 891
            |.|::|:|||||.||||||||:.|||||||||||::.|.||..|:.|||:||::|||.|||..||
  Rat   850 PGNFFHVLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPEDGPAAQNPDKVK 914

  Fly   892 KVVFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAELVWAQEEHKNQG 956
            :::||:|:||||||:.|:.:.:..|:||.|:||:|||||||:.::|..|.||||.|.||||||||
  Rat   915 RLLFCTGKVYYDLTRERKARDMAEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEHKNQG 979

  Fly   957 SWTYVQPRFLTALNHSRDVSQSDEQSSSTNTTTTTDHTNHESDTDSDSKSKPWLSRMFAAPNSST 1021
            .:.||:||..|.::.::.|                                 |
  Rat   980 YYDYVKPRLRTTIDRAKPV---------------------------------W------------ 999

  Fly  1022 GGDPKDPAQTLGGDFNAAKHFDLKNVRHDFNRPAGIAAAPGARIAKTGRKISYVGRACGASTATG 1086
                                                                |.||...|:.|||
  Rat  1000 ----------------------------------------------------YAGRDPAAAPATG 1012

  Fly  1087 SKAQHIRELNALLNDA 1102
            :|..|:.||...|:.|
  Rat  1013 NKKTHLTELQRFLDTA 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696	21/34 (62%)
		sucA	53..1104	CDD:236499	607/1079 (56%)
		TPP_E1_OGDC_like	259..521	CDD:238974	208/262 (79%)
		Transket_pyr	645..856	CDD:280874	156/211 (74%)
		OxoGdeHyase_C	863..1102	CDD:293475	74/238 (31%)
Ogdh	XP_038948146.1	sucA	49..1030	CDD:236499	607/1079 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335664
Domainoid	1	1.000	492	1.000	Domainoid score	I355
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55662
Inparanoid	1	1.050	1221	1.000	Inparanoid score	I173
OMA	1	1.010	-	-		QHG62893
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	1	1.000	-	-		otm45800
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810