DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nc73EF and SPBC3H7.03c

DIOPT Version :9

Sequence 1:	NP_001097629.1	Gene:	Nc73EF / 39899	FlyBaseID:	FBgn0010352	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_595772.1	Gene:	SPBC3H7.03c / 2540991	PomBaseID:	SPBC3H7.03c	Length:	1009	Species:	Schizosaccharomyces pombe

Alignment Length:	1110	Identity:	457/1110 - (41%)
Similarity:	633/1110 - (57%)	Gaps:	156/1110 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SSQQMAKVTAAAAV---RTYNSAAAEPFANGSTASYVEEMYNAWLRDPTSVHTSWDAYFR----- 85
            ::.::.::|..:::   ||:.:...:.|..|..|.||:|||:||.:||.|||.||.|||:
pombe    20 TAYRLNRLTCLSSLQQNRTFATQPTDDFLTGGAADYVDEMYDAWKKDPNSVHASWQAYFKNVQER 84

  Fly    86 ----SNSYVSPPNLAPVQANTLPLTAFNFGGAVAGAAPDSKTIDD----------HLAVQAIIRS 136
                |.::.:||.|....:.|               |.||..|:.          ::.||.::|:
pombe    85 GVSPSKAFQAPPLLDYADSYT---------------ALDSSLINGNNYADIDVGIYMKVQLLVRA 134

  Fly   137 YQIRGHNIAHLDPLEINTPELPGNSSTKSIYANFSFGEQDMDRQFKL-PS--TTFIGGDEASLPL 198
            ||.|||::|.||||.||...   |..::....::.|.|.|::|...| |.  ..|......::.|
pombe   135 YQSRGHHLAKLDPLGINVNH---NRPSELTLEHYGFTESDLNRTIHLGPGILPNFREAGRKTMTL 196

  Fly   199 KEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEKRLILARLTRATGFEAFL 263
            :||:...|.:||....|||..|:|.::.|||....|||....:|.::|.:|..||:.|..||.||
pombe   197 REIVETCEKIYCGSFAVEFTHISSRKRSNWILSHLETPTPFRYSHDQKIMIFDRLSWADSFERFL 261

  Fly   264 AKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLNTLANVCRKPLNQIFTQF 328
            ..|:.::|||||||||.|:|.:|.:||.|.:.|:.::::||.||||||.|.|:.|||...||::|
pombe   262 FTKFPNDKRFGLEGCEAMVPGMKALIDRSVDEGISNIVIGMAHRGRLNLLHNIVRKPAQAIFSEF 326

  Fly   329 AGLEAADD-GSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVDPVVQGKTRAEQFYRGDQ 392
            .|.:..|| ||||||||||...:| ...:.|.:.|::|||||||||.||||.||.||.|.|..|:
pombe   327 RGTQDPDDEGSGDVKYHLGMNYQR-PTPSGKRVSLSLVANPSHLEAEDPVVLGKVRAIQHYTSDE 390

  Fly   393 EG-KKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPYCT 456
            .. ::.|.|||||||||..|||||||..|..||.|:|.||:|:|.||||||||||||:||:||||
pombe   391 ASHEQSMGILIHGDAAFAAQGVVYETFGLHALPGYSTGGTVHIVINNQIGFTTDPRFARSTPYCT 455

  Fly   457 DVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPLMY 521
            |:|:.:.|||||||.||.|||..:|::||:||..|..|.|:|:|.|||:||||.|:|.||||.||
pombe   456 DIAKSMEAPIFHVNGDDVEAVTFICQLAADWRKAFKTDVVVDIVCYRRHGHNETDQPSFTQPRMY 520

  Fly   522 QKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTETHVKYKDWLDSPWSGF 586
            :.|.||.....:|..:|:.|.||:..||.:...:..:|.|.:|..:|.... .:::||.:||.||
pombe   521 KAIAKHPPTFKIYTQQLLQEKTVSKAEVDAQEKRVWDILESSFESSKNYKS-DHREWLSNPWVGF 584

  Fly   587 FEGKDPL-KVA---PTGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAAR-KAMVDEKVADW 646
            ...||.: |:.   ||||..:||..||....:.|..   |..|:.|.|:|..| |::...:..|.
pombe   585 ASPKDLMTKILPSYPTGVNIDTLKQIGKALYTLPEG---FDAHRNLKRILNNRNKSISSGEGIDM 646

  Fly   647 ALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPYSVSNS 711
            ...||:|||:||:||.|||:|||||||||||.||.|||.|..:. .|..|.|:.|:||.:.:.||
pombe   647 PTAEALAFGTLLEEGHHVRVSGQDVERGTFSQRHAVLHDQSSEN-VYIPLNHLSPNQASFVIRNS 710

  Fly   712 SLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQSGLVMLLPHGM 776
            |||||.|||||:|||:::|||||:||||||||:|.||.||||||::|::||::::|:|:.||||.
pombe   711 SLSEYGVLGFEYGYSLSSPNALVVWEAQFGDFANNAQCIIDQFIAAGETKWLQRTGIVLSLPHGY 775

  Fly   777 EGMGPEHSSCRVERFLQMSSDDPDYFPPESDEFGVRQLHDINWIVANCSTPANYYHILRRQIALP 841
            :|.||||||.|:||:||:.::||..||  |:|...||..|.|......:.|:.|:|.|||.|...
pombe   776 DGQGPEHSSARMERYLQLCNEDPREFP--SEEKLQRQHQDCNIQAIYVTKPSQYFHALRRNIHRQ 838

  Fly   842 FRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRII--PDNGPAGQNPSNVKKVVFCSGRVYYDL 904
            |||||::...|||||||.|:|...|..|...|:.|:  .::|.:...|..::|::.|||:|:..|
pombe   839 FRKPLVIFFSKSLLRHPAARSTIDEFDEKHGFKLILEEEEHGKSILPPEKIEKLIICSGQVWVAL 903

  Fly   905 TKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKN-AELVWAQEEHKNQGSWTYVQPRFLTA 968
            :|.|.|.::: .|||.||||:.||.:..:....:.|.| .|::|.|||..|.|:|||::||..|.
pombe   904 SKAREENKID-NIAITRVEQLHPFGWKQMAANISQYPNLKEIIWCQEEPLNAGAWTYMEPRIYTI 967

  Fly   969 LNHSRDVSQSDEQSSSTNTTTTTDHTNHESDTDSDSKSKPWLSRMFAAPNSSTGGDPKDPAQTLG 1033
            |.|                                                            ||
pombe   968 LKH------------------------------------------------------------LG 972

  Fly  1034 GDFNAAKHFDLKNVRHDFNRPAGIAAAPGARIAKTGRKISYVGRACGASTATGSKAQHIRELNAL 1098
            .|.                                  .:.|.||...||.|.|:|.||:.|....
pombe   973 RDL----------------------------------PVRYAGRPPSASVAAGNKQQHLAEQEQF 1003

  Fly  1099 LNDAI 1103
            ||||:
pombe  1004 LNDAL 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696	20/43 (47%)
		sucA	53..1104	CDD:236499	454/1083 (42%)
		TPP_E1_OGDC_like	259..521	CDD:238974	154/263 (59%)
		Transket_pyr	645..856	CDD:280874	119/210 (57%)
		OxoGdeHyase_C	863..1102	CDD:293475	57/241 (24%)
SPBC3H7.03c	NP_595772.1	SucA	39..1008	CDD:223641	453/1089 (42%)
		2-oxogl_dehyd_N	45..82	CDD:292696	20/36 (56%)
		TPP_E1_OGDC_like	257..520	CDD:238974	154/263 (59%)
		Transket_pyr	642..853	CDD:280874	119/213 (56%)
		OxoGdeHyase_C	860..1008	CDD:293475	58/242 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	346	1.000	Domainoid score	I181
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55662
Inparanoid	1	1.050	837	1.000	Inparanoid score	I56
OMA	1	1.010	-	-		QHG62893
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	1	1.000	-	-		otm47315
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	LDO	PTHR23152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R861
SonicParanoid	1	1.000	-	-		X894
TreeFam	1	0.960	-	-
	14	13.860