DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nc73EF and Dhtkd1

DIOPT Version :9

Sequence 1:	NP_001097629.1	Gene:	Nc73EF / 39899	FlyBaseID:	FBgn0010352	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	XP_036016106.1	Gene:	Dhtkd1 / 209692	MGIID:	2445096	Length:	940	Species:	Mus musculus

Alignment Length:	892	Identity:	358/892 - (40%)
Similarity:	509/892 - (57%)	Gaps:	94/892 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GGAVAGAAPDSKTIDDHLAVQAIIRSYQIRGHNIAHLDPLEINTPELPGNSSTKSIYANFSFGEQ 175
            ||:.|...       || .:..::..|...||..|.::||      .||.:...::..     .|
Mouse    65 GGSCAACV-------DH-GLARLVTVYCEHGHKAAQINPL------FPGQALLDTVPE-----IQ 110

  Fly   176 DMDRQFKLPSTTF----IGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETP 236
            .:.|..:.|.||.    :|.:.||  |:|:|..|.::||..|.:|...:.|.|:.:|..:|||..
Mouse   111 ALVRTLQGPFTTTGLLNLGKEAAS--LEEVLAYLNHIYCGPISIETAQLQSQEERDWFARRFEEL 173

  Fly   237 GVLNFSPEEKRLILARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVI 301
            ....|:.||::.:...|..:..|:.|||.|:::.||:|.||.|.|:....|::.:|...|:..:|
Mouse   174 KKETFTTEERKYLSKLLLESQEFDHFLATKFATVKRYGGEGAESMMGFFHELLKLSAYGGITDII 238

  Fly   302 MGMPHRGRLNTLANVCRKPLNQIFTQFAGLEAADDG---SGDVKYHLGTYIERLNRVTNKNIRLA 363
            :|||||||||.|..:.:.|...:|.:..||....:.   .|||..||.:.:: |:...::.:.:.
Mouse   239 IGMPHRGRLNLLTGLLQLPPELMFRKMRGLSEFPENVATIGDVLSHLTSSVD-LDFGAHQPLHVT 302

  Fly   364 VVANPSHLEAVDPVVQGKTRAEQFYRGD---------QEGKKVMSILIHGDAAFCGQGVVYETMH 419
            ::.||||||||:||..||||..|..|.|         |.|.||:.:.:||||:|||||:|.||..
Mouse   303 MLPNPSHLEAVNPVAVGKTRGRQQSREDGDYSPNGSAQPGDKVICLQVHGDASFCGQGIVLETFT 367

  Fly   420 LSDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHVCKVA 484
            ||:||.:...|:||::.|||:|:||.....|||.|.:|:.::|...|.|||.|.||.|:...::|
Mouse   368 LSNLPHFRIGGSIHLIVNNQLGYTTPAERGRSSLYSSDIGKLVGCAIIHVNGDSPEEVVRATRLA 432

  Fly   485 AEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIAEGTVTAEEV 549
            .|::..|.||.::||:.||:.||||:|||.||.|:||:.||..|:..|.||:.|||.|.:|.|||
Mouse   433 FEYQRQFRKDVIVDLLCYRQWGHNELDEPFFTNPVMYKIIRARKSIPDTYAEHLIASGLMTQEEV 497

  Fly   550 KSVAAKYENICEEAFALAKTETHVKYKDWLD-----SP--------WSGFFEGKDPLKVAPTGVK 601
            ..:               ||..:.|..|.|.     ||        |.|..:.:..:....|||.
Mouse   498 SDI---------------KTSYYTKLNDHLANVAHYSPPATNLQARWQGLVQPEACVTTWDTGVP 547

  Fly   602 EETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAARKAMVDEKV-----ADWALGEAMAFGSLLKEG 661
            .|.|..||.:....|   .|..:|..||::....:.   |||     .|||..|.:|.||||.:|
Mouse   548 LELLRFIGVKSVEVP---EELQVHSHLLKMYVQSRM---EKVKNGSGLDWATAETLALGSLLAQG 606

  Fly   662 IHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPY-SVSNSSLSEYAVLGFEHGY 725
            .:||||||||.|||||.||.::..|..|.| |..|.||.|:|..: .||||.|||.||||||:|.
Mouse   607 FNVRLSGQDVGRGTFSQRHAMVVCQDTDDA-YIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGM 670

  Fly   726 SMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQSGLVMLLPHGMEGMGPEHSSCRVER 790
            |:.:|..|.|||||||||.|.||.|.|.|||.|::||:.|||||:|||||.:|.||||||||:||
Mouse   671 SIESPTLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGLVILLPHGYDGAGPEHSSCRIER 735

  Fly   791 FLQMSSDDPDYFPPESDEFGVRQLHDINWIVANCSTPANYYHILRRQIALPFRKPLILCTPKSLL 855
            ||||.         :|.|.|| ....:|..|.:.:|||.|:|:||||:...||||||:.:||.||
Mouse   736 FLQMC---------DSAEEGV-DSDTVNMFVVHPTTPAQYFHLLRRQMIRNFRKPLIVASPKMLL 790

  Fly   856 RHPEAKSPFSEMSEGSEFQRIIPDNGPAGQNPSNVKKVVFCSGRVYYDLTKTRRE-KQLEGEIAI 919
            |:|.|.|...||:.|:.|:.:|   |.:..:|.|||.::||||:.:|.|.|.|.. ...:.:.||
Mouse   791 RYPAAVSTLEEMAPGTAFKPVI---GDSSVDPKNVKTLIFCSGKHFYALLKQRESLGTKKHDFAI 852

  Fly   920 VRVEQISPFPFDLVKEQANLYKNA-ELVWAQEEHKNQGSWTYVQPRF 965
            :|:|::.|||.|.::::.:.||:. :::|:|||.:|.|.|::|.|||
Mouse   853 IRLEELCPFPLDALQQEMSKYKHVRDVIWSQEEPQNMGPWSFVSPRF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696
		sucA	53..1104	CDD:236499	358/892 (40%)
		TPP_E1_OGDC_like	259..521	CDD:238974	115/273 (42%)
		Transket_pyr	645..856	CDD:280874	120/211 (57%)
		OxoGdeHyase_C	863..1102	CDD:293475	39/105 (37%)
Dhtkd1	XP_036016106.1	SucA	78..939	CDD:393462	353/871 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710