DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nc73EF and ogdh-2

DIOPT Version :9

Sequence 1:	NP_001097629.1	Gene:	Nc73EF / 39899	FlyBaseID:	FBgn0010352	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_001256410.1	Gene:	ogdh-2 / 179674	WormBaseID:	WBGene00014098	Length:	911	Species:	Caenorhabditis elegans

Alignment Length:	870	Identity:	336/870 - (38%)
Similarity:	485/870 - (55%)	Gaps:	85/870 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 IIRSYQIRGHNIAHLDPLEIN--------TPELPGNSSTKSIYANFSFGEQDMDRQFKLPSTTFI 189
            :|.:::..|:..|.||||.:.        .|.:.|.|..:::..|||
Worm    58 LINAFRRYGYLEADLDPLGLRKVESVAELDPAIYGLSLDENVKGNFS------------------ 104

  Fly   190 GGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEKRLILARLT 254
                    |.::..:|.::||....:|||.||:.|:..||.:.||.........||...|...:.
Worm   105 --------LHDLAEQLRHIYCGPTAIEFMHINNWEERQWISQNFENCIAEELRKEELLRIGDLML 161

  Fly   255 RATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLNTLANVCRK 319
            :...|:.||:.|:.:.||:|.||.|.|.....|:.:.:.|..||.:|:|:.||||||.|..:...
Worm   162 KCENFDKFLSTKFPTLKRYGAEGAESMFAFFSELFEGAAEKQVEEIIIGIAHRGRLNLLTQLMDF 226

  Fly   320 PLNQIFTQFAGL----EAADDGSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVDPVVQG 380
            |...:|.:..|.    |:| |.:|||..||.:..:  .:.:..|:.:.::.||||||||:||..|
Worm   227 PPVHMFRKIKGRAEFPESA-DAAGDVLSHLVSSFD--YKGSEGNVHVTMLPNPSHLEAVNPVAMG 288

  Fly   381 KTRAE--QFYRGD--------QEGKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVV 435
            |.||.  ...:||        :.|..|:::|:|||.||.|||||:|::.||..|.:...||:|:|
Worm   289 KARARAWSMNKGDYSPDERSARAGDSVLNVLVHGDGAFTGQGVVWESIALSQAPHFRLGGTVHLV 353

  Fly   436 ANNQIGFTTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLV 500
            .||||.||.:....|||.:|||:|:....|:.|||.|.||.|:...::|..:|..|.||..|:||
Worm   354 TNNQIAFTAESSVGRSSTHCTDIAKAFEYPVIHVNGDHPEEVVKATRLALAYRERFRKDVFINLV 418

  Fly   501 GYRRNGHNEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKY-ENICEEAF 564
            .:||.||||:|:|.||.|:||:::...::...|:.|:|:.||..|.|.||....|: |.:..|
Worm   419 CFRRWGHNELDDPTFTSPVMYKEVEARESVPRLFLDRLVEEGFTTEEAVKEQLQKHTEQLNNE-- 481

  Fly   565 ALAKTETHVKYKDWLDSPWSGFFEGKDPLKVAPTGVKEETLIHIGNRFSSPPPNAAEFVIHKGLL 629
             |.|.::.|.........|.||.:....::...|||..:.|..||......|   .:|..||.|.
Worm   482 -LKKVDSTVPIDISHRGRWEGFKQAPKAIESWDTGVATDLLRFIGAGSVKVP---EDFDTHKHLY 542

  Fly   630 RV---LAARKAMVDEKVADWALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKA 691
            ::   ...:|....|.: |||..|||||||:|.||..||:|||||.||||.|||.:    :||::
Worm   543 KMHIDSRMQKMQTGEGI-DWATAEAMAFGSILLEGNDVRISGQDVGRGTFCHRHAM----MVDQS 602

  Fly   692 T---YNSLQHMYPDQA-PYSVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIID 752
            |   :..|..:..:|. ...|:|:.|||.|:||||.|:|..||..|.:||||||||.|.||.|||
Worm   603 TDHIHIPLNELVEEQKNQLEVANNLLSEEAILGFEWGFSSENPRRLCIWEAQFGDFFNGAQIIID 667

  Fly   753 QFISSGQSKWVRQSGLVMLLPHGMEGMGPEHSSCRVERFLQMSSDDPDYFPPESDEFGVRQLHDI 817
            .|::|.:|||:..|||.||||||.:|.||||||||:|||||:.....|..|.:.:        ::
Worm   668 TFLASAESKWLTSSGLTMLLPHGFDGAGPEHSSCRMERFLQLCDSREDQTPVDGE--------NV 724

  Fly   818 NWIVANCSTPANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGP 882
            |..|||.:|.|.|:|:||||:...:|||||:..||.|||||:|.|..:|...|:.:|.:|.:.
Worm   725 NMRVANPTTSAQYFHLLRRQVVPNYRKPLIVVGPKILLRHPKAASTINEFGPGTTYQNVISEE-- 787

  Fly   883 AGQNPSNVKKVVFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANL--YKNA-E 944
            ...:...:|||:|.||:.:.::.|.|.|:.|:..:||||||.:.|||  :|..||.|  |..| :
Worm   788 HATSSQKIKKVIFVSGKHWINVEKARDERGLKDSVAIVRVEMLCPFP--VVDLQAVLKKYPGAQD 850

  Fly   945 LVWAQEEHKNQGSWTYVQPRFLTAL 969
            .||:|||.:|.|:|::|:|||..||
Worm   851 FVWSQEEPRNAGAWSFVRPRFENAL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696
		sucA	53..1104	CDD:236499	336/870 (39%)
		TPP_E1_OGDC_like	259..521	CDD:238974	113/275 (41%)
		Transket_pyr	645..856	CDD:280874	111/214 (52%)
		OxoGdeHyase_C	863..1102	CDD:293475	43/110 (39%)
ogdh-2	NP_001256410.1	sucA	56..911	CDD:236499	336/870 (39%)
		TPP_E1_OGDC_like	166..439	CDD:238974	113/275 (41%)
		Transket_pyr	557..763	CDD:280874	112/218 (51%)
		OxoGdeHyase_C	770..910	CDD:293475	43/110 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820