DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr73D and CPR144

DIOPT Version :9

Sequence 1:	NP_001097627.1	Gene:	Cpr73D / 39897	FlyBaseID:	FBgn0036680	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_316399.4	Gene:	CPR144 / 1276979	VectorBaseID:	AGAP006369	Length:	588	Species:	Anopheles gambiae

Alignment Length:	635	Identity:	261/635 - (41%)
Similarity:	346/635 - (54%)	Gaps:	116/635 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLCAVLGYFSDPARAEIEYNTISEDGSFQFRHANDDI-GGYYHSASGTPDNTVRGRYGSRSPAS 75
            ::|..:|..::|    :.::|.|:.||||.|...|.|. ||:||:|||.|...||||||||.|.:
Mosquito     9 VVLINLLPVYAD----QTDFNHINSDGSFAFGLKNSDTPGGHYHTASGNPKTIVRGRYGSRQPDT 69

  Fly    76 GQIEETVYTAGPRGFRVNGPKIHRKMDLAQYPVLPRGSPDDPLADPFDDPSYSFSFRTPDQSRSE 140
            |::|||||||||||||..|||||||..|:|....|.|:|:||||||:|||||.|.|:|.:..|.|
Mosquito    70 GRVEETVYTAGPRGFRARGPKIHRKQSLSQVQRGPIGTPEDPLADPYDDPSYDFQFKTRNYQRRE 134

  Fly   141 ENDSGNRIRGLYSYLDDVGERHSVRYAAGAGTGFEISNAVPDSPSVVAYSSPLYTSHPKARGKMS 205
            .:||..|:.|||:|:|||||:|||||:||:|||:|::|.|||:|:.:||.||||.:|.:.|||::
Mosquito   135 GSDSNGRVNGLYTYIDDVGEKHSVRYSAGSGTGYEVANPVPDAPNTIAYESPLYKTHKQVRGKVA 199

  Fly   206 VQRGPAGSYKLIASGSDHRRAESRAPDGLVRGTYSFLDDKGVQRTVEYIAGAGIGYRVVQNRIGP 270
            .:.||:||.:|::.|.|.||||:..|||:.||:||:||||||||||:|||||||||:|||:.:|.
Mosquito   200 FESGPSGSGQLLSVGPDQRRAETTGPDGVTRGSYSYLDDKGVQRTVQYIAGAGIGYKVVQSTVGA 264

  Fly   271 GTHNNPSVADFRLTDPDFRLANDFGRGAGGGLGPKGGGGGSGGGSVSVGASG--------PSGGA 327
            |||        ||..|:|.:::......|....|......||..|...|.||        ||.|.
Mosquito   265 GTH--------RLQQPNFGISHVEQSEIGDNNNPSYQTAPSGPASERPGTSGAGYDHVARPSAGG 321

  Fly   328 --GGAGRGRTPSRPGGKDYLKPADGARDRNRGDGDAGAADENLGHHADDQGDDIGLGSSSSGSTN 390
              ||:.|   |:.||| .|..|.                                 |.|.:||:.
Mosquito   322 YDGGSSR---PTAPGG-SYDPPT---------------------------------GPSGAGSSY 349

  Fly   391 FNG-KEDRRGFPAGSPQRGSTRYDAGGDSSQRGGSGSSTRNNVSGSRNRNRFGGVGGVSVSSERG 454
            .:| |....|:|..|...|. .||.....|:|..:.|.:....:..|..       |.|.|||..
Mosquito   350 PDGPKPGIPGYPESSRPTGQ-GYDEEDFDSKRPTTSSPSLRPPTTDRPT-------GPSDSSETS 406

  Fly   455 AGRGGAAGGGSSRRGGGAGASREGDSGLGYLPP------TGGSGTSAM----------------- 496
            ..:...:...:....||.|.    ||.:|.|||      ..|:|.||.
Mosquito   407 REKYPPSSDPTDHDLGGYGE----DSIIGLLPPKYDYEAQPGAGPSASDHDDHDTPSLSGPFDVA 467

  Fly   497 ----------------SGPGDNYHLNDDDVGSSLPPLVTANHRILEIDRDREWVQRHRDSTVIKN 545
                            |.||.|.:.::|..|.   |.||.:.:.||.||.::|....:|||:|||
Mosquito   468 ISSGPSGPAPYPSFGESAPGTNAYNSNDFSGF---PEVTYDQKKLEEDRKKDWRDFAKDSTIIKN 529

  Fly   546 VGKWYVGLPPGQSVRAHVQNIDIIPLGGRIGLSPSEALRQDEIAELNASR 595
            ||.|||||.||.|||||:||||::|.||| ..||.:|||:|..|:..:.|
Mosquito   530 VGDWYVGLAPGASVRAHIQNIDLLPYGGR-APSPGDALRRDTQAQAKSDR 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr73D	NP_001097627.1	Chitin_bind_4	127..174	CDD:278791	27/46 (59%)
Cpr73D	NP_001097627.1	Chitin_bind_4	<223..257	CDD:278791	24/33 (73%)
CPR144	XP_316399.4	Chitin_bind_4	121..168	CDD:278791	27/46 (59%)
		Chitin_bind_4	<217..251	CDD:278791	24/33 (73%)
		PHA02777	318..>470	CDD:165142	45/200 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	133	1.000	Domainoid score	I10263
eggNOG	1	0.900	-	-		E1_28MY6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I3758
OMA	1	1.010	-	-		QHG27619
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0019408
OrthoInspector	1	1.000	-	-		oto108159
Panther	1	1.100	-	-	LDO	PTHR10380
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14961
TreeFam	1	0.960	-	-
	11	10.930