DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmpt and CHS5

DIOPT Version :9

Sequence 1:	NP_996113.2	Gene:	Lmpt / 39889	FlyBaseID:	FBgn0261565	Length:	2147	Species:	Drosophila melanogaster
Sequence 2:	NP_013434.1	Gene:	CHS5 / 851041	SGDID:	S000004322	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	105/514 - (20%)
Similarity:	179/514 - (34%)	Gaps:	119/514 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1601 ERTQPTDESHHDTSECEEAERNAD----RYENRG--AQDWEEVDDVEDFLDYGFDDGAVGGATPY 1659
            :|....|.:|...::.:..|.|.:    ::.|..  ..:|....:||..:        ||....|
Yeast   205 QRHVAIDTTHFVCNDLDNEESNEELIRAKHNNIPIVRPEWVRACEVEKRI--------VGVRGFY 261

  Fly  1660 SDPDSFIEQIYNEAIKNRKQSGILREYETIV----QEQLPSDLSESEKEKSGSDSEKYALWAKTR 1720
            .|.|..|.:.|.....|.::....:|.|.:.    :.::|.|.::.|:..|.:|:|.....||.:
Yeast   262 LDADQSILKNYTFPPVNEEELSYSKENEPVAEVADENKMPEDTTDVEQVASPNDNESNPSEAKEQ 326

  Fly  1721 ELERSHSGTRHSDVDIALGLIPESDHRDSEMRYLGDAHVVARQSTRLRTRYGFNPKLEVGD---- 1781
            ..:..|.....|.|:..|       |..:.:........|......|::.....|.:|...
Yeast   327 GEKSGHETAPVSPVEDPL-------HASTALENETTIETVNPSVRSLKSEPVGTPNIEENKADSS 384

  Fly  1782 ----LEDDIEVDLNYKPKREYNWRKNFRLD--DNEEGERSVQVKTEE-----------DEEQEAR 1829
                :|:..|......|..|...:|:...|  .||:.:... |:|||           .|..|..
Yeast   385 AEAVVEEPNEAVAESSPNEEATGQKSEDTDTHSNEQADNGF-VQTEEVAENNITTESAGENNEPA 448

  Fly  1830 DQFEEEFGWQDREQELEE--ELYQDHEQPLYANEENGEIENVELLENRRISLGGESITLFSRSPV 1892
            |....|||..:.|.|..|  |..:|..:|  |.:.|..:|:                   |..||
Yeast   449 DDAAMEFGRPEAEIETPEVNESIEDANEP--AEDSNEPVED-------------------SNKPV 492

  Fly  1893 REILPDVPEELPQEEEALEEQPEAVAPLEDLPAEKPKKKKSKKKLRKGSKTEEELRDDNDSDTQM 1957
            ::....|.:.....|::.:...::..|:||  |.:|.:..|:.....|    |.:::.|:..|.:
Yeast   493 KDSNKPVEDSNKPVEDSNKPVEDSNKPVED--ANEPVEDTSEPVEDAG----EPVQETNEFTTDI 551

  Fly  1958 GSSRRSDDQ-----EPTD--------------PPKRKTRSRRSSRSSLTNEEPNGGSGPFSPRSS 2003
            .|.|..::.     ||.|              .|:.|........::::.|..:|.|.......:
Yeast   552 ASPRHQEEDIELEAEPKDATESVAVEPSNEDVKPEEKGSEAEDDINNVSKEAASGESTTHQKTEA 616

  Fly  2004 LAFVGESLEGIAEFEPQEREEEQ--------------------STKKRTKKRKKTSTKE 2042
            .|    |||..|..|.||..|.:                    |.||:.||.||...|:
Yeast   617 SA----SLESSAVTEEQETTEAEVNTDDVLSTKEAKKNTGNSNSNKKKNKKNKKKGKKK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmpt	NP_996113.2	GBP_C	<103..201	CDD:303769
		ARGLU	110..255	CDD:291991
		coiled coil	170..181	CDD:293879
		coiled coil	190..201	CDD:293879
CHS5	NP_013434.1	Chs5_N	4..76	CDD:260117
		fn3_2	77..165	CDD:407129
		BRCT_CHS5_like	172..255	CDD:349373	9/57 (16%)
		MDN1	<366..607	CDD:227596	53/268 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900