DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmpt and CG1647

DIOPT Version :9

Sequence 1:	NP_996113.2	Gene:	Lmpt / 39889	FlyBaseID:	FBgn0261565	Length:	2147	Species:	Drosophila melanogaster
Sequence 2:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	1373	Identity:	260/1373 - (18%)
Similarity:	447/1373 - (32%)	Gaps:	400/1373 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 EKALSIDEEEI-ELERP------SRGEDVEEEATNEPKSSSFEEATEAQNEQAVAALKQQLSKEQ 671
            |.|..||.:.| :.|||      .||...:.| .:.||:::.:  .:.:.|..|...||:|...|
  Fly   106 EPARLIDLKRIVKEERPISGAVGKRGRKRKGE-ESWPKNNNVK--PQVKKESFVWHKKQKLQPSQ 167

  Fly   672 L-----DKEAE-KDNPQAVDTS-------DSNKS--------NLQTSIAAEEQSRGGSPGLRRSP 715
            :     .:|.| ||.|...|||       ...||        .|...:|.|.:|....|.:   |
  Fly   168 ITSLVSKREPEIKDEPAEQDTSLKGPPKKAGRKSICSVCGEKFLSKELADEHKSLVHVPSI---P 229

  Fly   716 R-----MDEMEHYPERWSASQEQQSVQQQPPRTAPAINVQQPDTAPWRDQYGLLMEGLSDFYDFT 775
            |     .::..|......|.|....:.:.|.:..                  |....:::.|.||
  Fly   230 RYICNACNQTHHNQSDIRAHQLWHKLSKTPYKCP------------------LCESSVANAYAFT 276

  Fly   776 ASVNPSRSRSASRNPSPAPKNVANLMD----------------------------GDTERSLEVY 812
                    |....:..|.|..:. ::|                            |...|:|
  Fly   277 --------RHLREHTPPTPVQLL-VLDRECPLCKKTFVTNFFYNTHRCAIRKRKCGGCSRTL--- 329

  Fly   813 DDTQEGVMAGELNCESVLQLLESNLNETESTNDQLQVQTVADDARDGKSILPMVHEPLESSALGA 877
             :|:...|.....|..:.      ||.::    .:..|.|.::|:      .::...:|...||.
  Fly   330 -NTEAAYMRHAPTCPKIY------LNHSK----HIMPQVVTNEAQ------MLIKNEIEEELLGL 377

  Fly   878 ----------VLEERGREPSVGRIQSRSRSRSRSPLPTS----ENLEKSIHKRRERL-----IKQ 923
                      |::| |.:|.|      ...|..|||..|    :.|..:..|..:|:     :|:
  Fly   378 PPATTVPPDFVIDE-GMQPVV------VLERLSSPLLRSSSGTDQLVAAKSKNSDRVSARNYLKR 435

  Fly   924 NDELAERLSHSSPEDSMEIETSDNGRLSPTLEVTLPQPVIEINEMADEPMEDAETTPEEMRLFVE 988
            .|:|.:...:                   ||.....:|.:.||: ...|...||:.||
  Fly   436 VDQLLKNTIN-------------------TLVSIKHEPEVHIND-TGPPRGQAESDPE------- 473

  Fly   989 TLRAERNARSRSRSRSRSPLPTAG-NIEKSLESRRLKRIQHNDEIFEKLHDQMSSPQIIIESASP 1052
               .|||...          |:.| :|:.:           |||. ::...:..|.:|.:.:..
  Fly   474 ---PERNEEH----------PSFGDDIQAA-----------NDEC-QECQPETESDKISVAACD- 512

  Fly  1053 PSLPLPLPTISIEIAEPPE----ENASHTEAEP-------------------EDTPESMARLFEQ 1094
                 .:|::|::  :.||    |..:..:.||                   :|..|:.......
  Fly   513 -----DIPSVSVK--QEPEYDGYEKQTGVKQEPLKLKLKITKNHGKLNSSLIDDLDEAGQAFGRS 570

  Fly  1095 LRLNRVRSHSRSRSRSPLPTPANLEQSVQKRRERLIAQNDQFFEVLQERARTPEPETRLTVEYVY 1159
            .:..:.|.| :.|.:         |.|.:....|..:||....::.||........|.:|...:.
  Fly   571 SKKKKKRKH-KEREK---------EASNETENCRTESQNQPAIKIKQEPVDYAPEATVMTTIPMT 625

  Fly  1160 EYVQEKDEQVGEGRDKRSLSPSRSRSQSQEKALDDFHLMLNLEGSELRTLRKNSEELESVLAVGA 1224
            ::....:|      .:||.....:..||||                  .::.|..||:.::.:..
  Fly   626 QFESSLNE------SERSEEVDEAMIQSQE------------------DVKPNRMELDRMMQISN 666

  Fly  1225 KQREVDMD----ALEKLHNANEEIELRVLSPTNSELERV---VEMTRENPDMDRTVSEVARDLQD 1282
            ....|||.    |||:...|..|..|..:....|...:.   .|....:|....|:.::...:..
  Fly   667 VTSGVDMAEEAMALERAEEACPEDSLHKVKSVKSTARKSTGGAERKTYSPPRTNTLPQIVAVVSG 731

  Fly  1283 ELMASGFKRSTYVGESLDLG-SDQFKELRREAAQ------FQRSRSPSPGSSMDYAREQAAAQRE 1340
            |   |.|...:...|..:|| .|:..|.:||..:      .........| |:|.:......:||
  Fly   732 E---SAFNMISIKPEPRNLGYGDEEPEDQRETTEEINHNDMMEEEKEYIG-SLDLSDVSVKQERE 792

  Fly  1341 LQTAILDSLTESRLGAKPKTYSEERTGEFEDISAAQLDDLRHRTAEFQRSRSQSRSPLREVELTQ 1405
            |....:|::..:.|     ..|:|...:..:.||:..|:     ||....|.......||:||..
  Fly   793 LDICEIDAVHRNGL-----EKSDEDDDDGNEDSASSADE-----AEEAMERDTEERIYREIELPP 847

  Fly  1406 LRDIEAESAKRELQDQLLDRLAASSINFENFSRHLNADFLDSERRASDSALMGDMEPDEYHHFRR 1470
            | :::.||::::|:.:.:|...::::.             .||..:....::| :|..|...|..
  Fly   848 L-ELQNESSRKDLESERMDTEVSTALP-------------ASETPSQTRDVLG-VEKSEASAFSL 897

  Fly  1471 Y-----SLAQEQPVEEYPSDDYVYISQIEVRTLTGTRTWLKEDFYTHEPNDFS--DSKSPVRDED 1528
            .     |.|..||.....:|       ||........|       |:||:..:  :.:||..|..
  Fly   898 VITNICSQAVPQPSAACSND-------IECSIGPSPST-------TNEPHSHTVENVQSPANDLQ 948

  Fly  1529 SWARAVLAAEAEAAEFDSTNAIYSYDIVGDHENLDQERSSSNDSEDTRQTVVEIDDEDEFEFELD 1593
            :.|:..:||:::.                |...:.|..:||....||:...........|
  Fly   949 TSAQVAIAAQSQP----------------DPCIVSQPAASSESQADTKDLPPAASQIQTF----- 992

  Fly  1594 EGISDNNERTQPTDESH-HDTSECEEAERNADRYENRGAQDWEEVDDVEDFLDYGFDDGAVGGAT 1657
                  |..:.|.   | |..:|....|.:|...|:|...|.:....
  Fly   993 ------NTESLPI---HVHSETEDNSIENDASYLESRAQVDCQSAGT------------------ 1030

  Fly  1658 PYSDPDSFIEQIYNEAIKNRKQSGILREYETIVQEQLPSDLSESEKEKSGSDSEKYALWAKTREL 1722
              .:|...:||  ||::.:......:.|..:........|.|||..:...:....|.|...:.:.
  Fly  1031 --ENPSVVLEQ--NESLPSGSCVSPIPENPSPGNSPPQHDESESLDKPEMAAGSAYCLATVSLDA 1091

  Fly  1723 ERSHSGTRHSDVDIALGLIPESDHRDSEMRYLGDA-------HVVARQSTRLRTRYGFNPKLEVG 1780
            .:        |.: ||.| |..|....:..|..|.       |.::.|...:..........|..
  Fly  1092 PK--------DTE-ALAL-PPCDAAIIDSNYTSDEEQQNVLNHELSEQQLAIMEHRQLLVHEEQP 1146

  Fly  1781 DLEDDIEVDLNYKPKREYNWRKNFRLDDNEEGERSVQVKTEEDEEQEARDQFE-EEFGWQDREQE 1844
            .|.:.|...|:.:|..|...|.|.:..|.|:||       |.....:|.|... .|....:....
  Fly  1147 ALLEVIPPGLSSRPIEETENRINEQQQDLEQGE-------ERPPRFQANDDSNINEIAENNNNAN 1204

  Fly  1845 LEEELYQD 1852
            :|.||..|
  Fly  1205 IERELQDD 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmpt	NP_996113.2	GBP_C	<103..201	CDD:303769
		ARGLU	110..255	CDD:291991
		coiled coil	170..181	CDD:293879
		coiled coil	190..201	CDD:293879
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368	4/20 (20%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		C2H2 Zn finger	262..282	CDD:275368	5/45 (11%)
		C2H2 Zn finger	297..314	CDD:275368	0/16 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900