DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmpt and Leo1

DIOPT Version :9

Sequence 1:	NP_996113.2	Gene:	Lmpt / 39889	FlyBaseID:	FBgn0261565	Length:	2147	Species:	Drosophila melanogaster
Sequence 2:	NP_001005548.1	Gene:	Leo1 / 300837	RGDID:	1549772	Length:	678	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	157/789 - (19%)
Similarity:	299/789 - (37%)	Gaps:	253/789 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ADAEELPRMRERLDKQIKEAAER-EALAGTNVMQDGVLYVNGIRV-------DPAGDKRQALAAE 108
            ||.|:|      ...:.:..||| ::.:|::...|.....:|...       |..||..|....|
  Rat     2 ADMEDL------FGSEAESEAERKDSDSGSDSDSDQDNGASGSNASGSESDQDERGDSGQPSNKE 60

  Fly   109 LARQQQIE--------ADTRRQLAEAEAKLVEERLRVQREKEESEEQQRKLVEA----------- 154
            |......|        :|...:.::..::..||| ....:.|.|:..|....||
  Rat    61 LFGDDSEEEGAPHHSGSDNHSEQSDNRSEASEER-SDHEDNEPSDVDQHSGSEAHNDDDDDDDDE 124

  Fly   155 ----ERQRERE---QAEKELQEQREAERRQLEAEENQRKQRENEEKERLENERRLIDAEREREEN 212
                |..|..|   .:|.|..|:.:::..:.:.|:   |..::::.|:|:|..   |.|||:..:
  Rat   125 DDDDEGHRSDEGSHHSEAEGSEKAQSDDEKWDGED---KSDQSDDDEKLQNSD---DEEREQGSD 183

  Fly   213 ERRLQ---EAEEQREREESERRIVVAERQREQ-AEAEKERAEQQRILAEAEAAQAERRLFDAEIQ 273
            :.:||   :.||:.:..:.|.|..:::..|:| :|.||..::.:|..|             ::..
  Rat   184 DEKLQNSADEEEKMQNTDDEDRAQLSDDDRQQLSEEEKGNSDDERPAA-------------SDND 235

  Fly   274 RERDQADEEGQALRDAEIVERLLAAERELSPSATESEL-----EEDAAIAEQSRRLISSRTDLEQ 333
            .|:..:|:|.:                   |..::.|.     :|...::::.||    .:|.|:
  Rat   236 EEKQNSDDEDR-------------------PQVSDEEKMQNSDDERPQVSDEDRR----HSDDEE 277

  Fly   334 KQRMIEENARRFLEAEEEMVMLQQRQLQASHSKEEADE------------YAGMEPVV-----EE 381
            :|....|:||. .::|:|::.::::....|.|:.::|.            :.|.:.:.     |:
  Rat   278 EQDQKSESARG-SDSEDEVLRMKRKNAIPSDSEVDSDTEVPKDNNGTMDLFGGADDISSGSDGED 341

  Fly   382 LCVKKVAPPRFQEP-----------PEEPM--------VHKVKTQFGQGSGPEDAYSAKSKTLTF 427
                  .||...:|           .|||:        :.||.|..|     .|.|..|.....
  Rat   342 ------KPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLG-----NDLYFVKLPNFL- 394

  Fly   428 PGVSDEGSSLEPKTPFSIQ--QSSFSTQP--SDEGN-----RIESE-----RPEPEGEDQIQE-- 476
                    |:||: ||..|  :..|..:.  .:||.     ::|:.     |.:.|| ::|:|
  Rat   395 --------SVEPR-PFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRMRRDEEG-NEIKESN 449

  Fly   477 ---VQYTED-------------YLRSLDGIKNRPLMREDGSG--RRRAFKK----RRSSGSSNSS 519
               |::::.             |...|.|..|...:|: |:|  .:..||.    |..|..|.:.
  Rat   450 ARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQ-GTGLQGQAVFKTKLTFRPHSTDSATH 513

  Fly   520 RE------SRASRDEELKMF-----------TSL---EEEELRHGDREDYNPIKYTSEPTLRVKS 564
            |:      .|.|:.:::::.           |.:   |||.||...|.:      :.:..:|.|.
  Rat   514 RKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRE------SQQRRMREKQ 572

  Fly   565 HRRHKRSPAKDVRPTAESTTSLEMLGEESTNPWGEVVPEHYKDTEFWKREKALSIDEEEIELERP 629
            |:|            ..|.:.||              |:.|.:.|  :.|:::|:    ..::..
  Rat   573 HQR------------GLSASYLE--------------PDRYDEEE--EGEESVSL----AAIKNR 605

  Fly   630 SRGEDVEEEATNEPKSSSFEEATEAQNEQAVAALKQQLSKEQLDKEAEKDNPQAVDTSDSNKSNL 694
            .:|...||.|  ...||..:|.:|....|.:...|:..|.|:.:...::   :|.|...:||.:.
  Rat   606 YKGGIREERA--RIYSSDSDEGSEEDKAQRLLKAKKLNSDEEGESSGKR---KAEDDDKANKKHK 665

  Fly   695 QTSIAAEEQ 703
            :..|:.||:
  Rat   666 KYVISDEEE 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmpt	NP_996113.2	GBP_C	<103..201	CDD:303769	24/123 (20%)
		ARGLU	110..255	CDD:291991	37/174 (21%)
		coiled coil	170..181	CDD:293879	0/10 (0%)
		coiled coil	190..201	CDD:293879	3/10 (30%)
Leo1	NP_001005548.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..373		81/426 (19%)
		PHA02664	<33..183	CDD:177447	32/156 (21%)
		PHA02664	<134..259	CDD:177447	31/162 (19%)
		Leo1	386..544	CDD:281933	33/169 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..596		12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..678		17/67 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900