DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmpt and Rp1

DIOPT Version :9

Sequence 1:	NP_996113.2	Gene:	Lmpt / 39889	FlyBaseID:	FBgn0261565	Length:	2147	Species:	Drosophila melanogaster
Sequence 2:	NP_035413.1	Gene:	Rp1 / 19888	MGIID:	1341105	Length:	2095	Species:	Mus musculus

Alignment Length:	1910	Identity:	352/1910 - (18%)
Similarity:	611/1910 - (31%)	Gaps:	691/1910 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 TFPGVSDEGSSLEPKTPFSIQQSSFSTQPSDEGNRIESERPEPEGEDQIQEVQYTED---YLRS- 486
            ||..:.|   ||..|.|......:.||               |.|...|..::..||   |:.|
Mouse    61 TFDALLD---SLSRKVPLPFGVRNIST---------------PRGRHSITRLEELEDGKSYVCSH 107

  Fly   487 --------LDGIKNRPL--------------------MREDGSGRRRAFKKR---RSSGSSNS-- 518
                    ||..:.||.                    |.....|..||.::.   |:....|.
Mouse   108 NKKVLPVDLDKARRRPRPWLSSRSISTHVQLCPATANMSTMAPGMLRAPRRLVVFRNGDPKNKHV 172

  Fly   519 ---SRESRASRDEELKMFT-------------------SLEEEELRHG-----DREDYNP----- 551
               ||....|.:..|:..|                   ||:...|..|     .||.:.|
Mouse   173 VLLSRRITQSFEAFLQYLTQVMQCPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDI 237

  Fly   552 IKYTSEPTLRVKSHRRHKRSPAK------------DVRPTAESTTSLEMLGEESTNPWGE--VVP 602
            .||.....|...|||.|::..||            |:||..:|     ::.|::.:.:.:  |.|
Mouse   238 QKYLLPAKLPGISHRVHQKGKAKIEKRKMSTHMPSDLRPQTDS-----LISEKTYDCFSDFSVAP 297

  Fly   603 EHYKDTEFWKREKALSIDEEEIELERPSRGEDVEEEATNEPKSSSF-EEATEAQNEQAVAALKQQ 666
            |:|         .||...|.:.....||. :|||       ||..| ::.|..    .|..::.:
Mouse   298 ENY---------LALETHESQSLSTYPSE-DDVE-------KSIVFNQDGTMT----VVMKVRFK 341

  Fly   667 LSKEQLDKEAEKDNPQAVDTSDSNKSNLQTSIAAEEQSRGGSPGLRRSPRMDEMEHYPERWSASQ 731
            :.:|:..|.....|...:  |::::.|.::|...:......|..|......:::....::.|.::
Mouse   342 IKEEETVKWTTTVNRAGL--SNNDEKNKKSSYPGKTDYGPSSLKLEACSLPEDIVDTTQQGSLTE 404

  Fly   732 EQ--QSVQQQPPRTAPAINVQQPDTAPWRDQYGLLMEGLSDFYDFTASVNPSRSRSASRNPSPAP 794
            |:  |..:||      |::.   .:|.|.:   ..||  :|..:....|     :...|.|:|.|
Mouse   405 EENTQMTEQQ------ALSC---SSASWEN---ASME--TDIQESQKQV-----KHFYRPPTPGP 450

  Fly   795 K----------NVANLMDGDTERSLEVYDDTQEGVMAGELNCESVLQLLESNLNETESTNDQLQV 849
            :          .|..:.:.:.:.....|.:.::|   ||   :|...:...:.::..|.:::| |
Mouse   451 RRMRQKKSVIGTVTVVSETEVQEKQFSYSEERKG---GE---KSEYHMFTHSCSKMSSVSNKL-V 508

  Fly   850 QTVADDARDGKSILPMVHEPLESSALGAVLEERGREPSVGRIQSRSRSRSRSPLPTSENLEKSIH 914
            |..:|:..:              |||     ||.||.  |.::|::.:.....: ||:.:.|..|
Mouse   509 QIGSDNEME--------------SAL-----ERTRES--GSLKSQAINAGAIEI-TSQKVLKMCH 551

  Fly   915 KRRERLIKQNDELAERLSHSSPEDSMEIETSDNGRLSPTLEVTLPQPVIEINEMADEPMEDAETT 979
            .             ..|..::||:|:..|.:||..:|.|..:...:.....|:....  ..|::|
Mouse   552 N-------------NALPSTAPENSVVEEGTDNSAVSGTATIKHFRTCGNANDSFSS--ITADST 601

  Fly   980 PEEMRLFVETLRAERNARSRSRSRSRSPLPTAG----------------------NIEKSLESRR 1022
            |..:..:             |..|:.|.||:.|                      |.:|.|.|..
Mouse   602 PTSVNNY-------------SNDRNISELPSVGSPVLTMRLVNEFAHCGLTEKPENRKKVLSSSA 653

  Fly  1023 LKR---------IQHNDEIFEKLHDQMSSPQIIIESASPPSLPLPLPTIS-------IEIAEPPE 1071
            .|:         |..||:            :.:||:..||::...:|...       ::.::.|:
Mouse   654 SKKKKKKSQQRMITSNDK------------KKVIETKGPPNIAGKIPRAGTTAQERLLQESDCPD 706

  Fly  1072 E---------NASHTEAE-----PEDTP-------ESMARLFEQLRLNRVRSHSRSRSRSPLPTP 1115
            :         |.|....|     |:..|       ::....|:..:..::.:..:||.|..:
Mouse   707 KGGRVCEQGLNISPMAIESNNFFPKSNPTFSKNFYKNKLNTFQNPKTQKLLAKRKSRPRKIV--- 768

  Fly  1116 ANLEQSVQKRRERLIAQNDQFFEVLQERARTPEPE-TRLTVEYVYEYVQEKD----------EQV 1169
                 |.::.|::.|.|.|:.  :|...::..|.. .:.::.:|:..::|..          |:|
Mouse   769 -----STERLRKQEIGQEDKI--LLHSDSKLCESHLEKQSLFHVFNILEEDQKVLHRPPFQVEKV 826

  Fly  1170 G---EGRDKRSLSPSRSRSQSQEKALDDFHLMLNLEGSELRTLRKNSEELESVLAVGAKQREVDM 1231
            .   :|..|:||.|.          ::|.|:|          ||...:::...|..||:..|..:
Mouse   827 ARNLKGMAKKSLVPK----------VNDLHIM----------LRNQKKQMGVKLKSGAEVSEQHV 871

  Fly  1232 ----DALEKL----------HNANEEIELRVLSPTNSELERVVEMTRENPDMD-RTVSEVARDLQ 1281
                |.|..|          |::.:....|.|...||           .||.: |....:.::..
Mouse   872 TTRADPLASLKKPDFPEGIPHHSGKSYVKRWLQNINS-----------YPDFEHRKSGPLCQNRS 925

  Fly  1282 DELMASGFKRSTYVGESLDLGSDQFKELRREAAQFQRSRSPSPGSSMDYAREQAAAQRELQTAIL 1346
            |.:   .:.|:.::|.:|...|.:......|:   .:|::.:...|.:..:|
Mouse   926 DVV---NYNRNGFLGNNLHTTSSKGNGFLMES---NKSKTKNDNWSGNTNQE------------- 971

  Fly  1347 DSLTESRLGAKP------KTYSEERTGEFEDISAAQLDD---LRHRT---------AEFQRSRSQ 1393
               |...|.||.      |.:.|.:.|...|.....|.|   |...|         ...::||.:
Mouse   972 ---TGKSLVAKDNGEELNKHHCESQNGSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPE 1033

  Fly  1394 SRSPLREVEL-TQLRDIEAESAKRELQDQLL-DRLAASSINFENFSRHLNADFLDSERRASDSAL 1456
            .:...:|:.. |:.:.||.......:.:.:| |.|.|..:      |||.|
Mouse  1034 VKLVYQEMNFATKRQSIEVAIQVDTMGENVLKDYLPALLL------RHLEA-------------- 1078

  Fly  1457 MGDMEPDEYHHFRRYSLAQEQPVEEYPSD--DYVYISQIEVRTLTGTRTWLKEDFYTHEPNDFSD 1519
               ..|:...|        :..:.:.|..  :.|:.|.|:..:......||.........|.|..
Mouse  1079 ---FVPNNQKH--------QNGISQIPGSLAEVVFPSVIDNSSTNLLLAWLLVLNLKRTMNSFCQ 1132

  Fly  1520 S---KSPVRDEDSWA-RAVLAAEAEAAEFDSTNAIYSYDIVGDHENLDQERSSSNDSEDTRQTVV 1580
            |   |...|..::.| ..||...|...|.|...|..:        ||.:...:.:.|....|.::
Mouse  1133 SDAHKMTNRPSETAALLEVLKHVAITEEADDLKAAVA--------NLMESTKTCSGSSGREQDML 1189

  Fly  1581 EIDDEDEFEFELDEGISDNNERTQPTDESHHDTSECEEAERNADRYENRGAQDWEEVDDVEDFLD 1645
            .::                     .|..|.|...||.         ||..||        :..||
Mouse  1190 PVN---------------------CTASSLHSVDECN---------ENGSAQ--------KTLLD 1216

  Fly  1646 YGFDDGAVGGATPYSDPDSFIEQIYNEAIKNRKQSGILREYETIVQEQLPSDLSESEKEKSGSDS 1710
            .|:  ..:|..|                                         ||...:...|..
Mouse  1217 EGY--SVMGDCT-----------------------------------------SEMVSKSCNSSC 1238

  Fly  1711 EKYALWAKTRELERSHSGTRHSDVDIALGLIPES----DHRDSEMRYLGD---AHVVARQSTRLR 1768
            |.:.: :||...::...   .||     ||:..:    ..|.:...:|.|   :|....|...:
Mouse  1239 EMHMV-SKTNPPKQVDD---QSD-----GLLTSNSCTVSQRSTGACFLTDGVYSHEACAQKEGV- 1293

  Fly  1769 TRYGFNPKLEVGDLEDDIEVDLNYKPKREYNWRKNFRLDDNEEGERSVQVKTEEDEEQEARDQFE 1833
                    .|...|.|:..:     |.|:.:                 .:.:...:|.:..|..|
Mouse  1294 --------YEGACLSDETHI-----PIRDCH-----------------TIHSVHSKENKCTDDLE 1328

  Fly  1834 EEFGWQDREQELEEELYQDHEQP---------LYANEEN-GEIENVELLENRRISLGGESITLFS 1888
            .           .|||....:.|         :|.|:.| ...:||..|.::|        ||.|
Mouse  1329 S-----------TEELKTVDKVPKGLSILADSMYKNDSNVSTFQNVNKLSSQR--------TLLS 1374

  Fly  1889 RSPVREILPDVPEELPQEEEALEEQPEAVAPLEDLPAEKPKKKKSKKKLRKGSKTEEELRDDNDS 1953
            ::.:                   :..:..:|||:. ...|:||...||....|..||
Mouse  1375 KTYL-------------------DSDKDYSPLEEF-QNCPRKKIVNKKKSISSDKEE-------- 1411

  Fly  1954 DTQMGSSRRSDDQEPTDPPKRKTRSRRSSRSSLTNEEPNGGSGPFSPRSSLAFVGESLEGIAEFE 2018
                  ||.|  :||           ||..:|:|:.|.|                    .|:|.|
Mouse  1412 ------SRTS--EEP-----------RSITNSMTSSERN--------------------AISELE 1437

  Fly  2019 PQEREEEQSTK--KRTKKRKKTSTKECKEEAKEETQTQAIDDSQLDRALAAALAEIAPVSVSTNL 2081
            ..|..|.|.|.  ....:.:|.||||..::..|                |...:|:..||....:
Mouse  1438 SFEELESQDTSIFNMNVRAEKKSTKETMQKQSE----------------ARMSSELINVSGRKII 1486

  Fly  2082 TPESTHQNLLSTISTGQSVCITPAS 2106
            ..|..:..:|.|.:.||   :||.|
Mouse  1487 EQERRNTAILETTARGQ---VTPPS 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmpt	NP_996113.2	GBP_C	<103..201	CDD:303769
		ARGLU	110..255	CDD:291991
		coiled coil	170..181	CDD:293879
		coiled coil	190..201	CDD:293879
Rp1	NP_035413.1	DCX	35..110	CDD:176357	16/66 (24%)
		DCX	157..232	CDD:176357	13/74 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..379		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..688		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..887		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1400..1430		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900