DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmpt and MUCL3

DIOPT Version :9

Sequence 1:	NP_996113.2	Gene:	Lmpt / 39889	FlyBaseID:	FBgn0261565	Length:	2147	Species:	Drosophila melanogaster
Sequence 2:	NP_543146.2	Gene:	MUCL3 / 135656	HGNCID:	21666	Length:	1393	Species:	Homo sapiens

Alignment Length:	1453	Identity:	279/1453 - (19%)
Similarity:	474/1453 - (32%)	Gaps:	393/1453 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 EESEEQQRKLVEAERQREREQAEKELQEQREAERRQL----EAEENQRKQ--------RENEEKE 194
            ||:...|.|......||..:.|:.....:..|.::.:    :::.|.||.        |::::..
Human   122 EENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTTGKSTVTRKSDKTG 186

  Fly   195 R-LENERRLID-AEREREENERRLQEAEEQREREES---ERRIVVAERQREQAEAEKERAEQQRI 254
            | ||.....:| ......:.......:...:.:::|   ..:|..|.:...:.....|.:|:..
Human   187 RPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTE- 250

  Fly   255 LAEAEAAQAERRLFDAEIQ--RERDQADEEGQALRDAEIVER--LLAAERELSPSATESELEEDA 315
              ::....|..:|.....:  :|...|:|..|:|  ||..|.  ..|.|......|..:|..|..
Human   251 --DSRTTVASDKLLTKTTKNIQETISANELTQSL--AEPTEHGGRTANENNTPSPAEPTENRERT 311

  Fly   316 AIAEQSRRLISSRTDLEQKQRMIEENARRFLEAEEEMVMLQQRQLQAS------------HSKEE 368
            |   .....:|....:|.::|...||...|.....|     .|::.|:            |.:..
Human   312 A---NENTTLSPAEPIENRERTANENTAPFPAGPTE-----NREMTANENTTLFPAEPTEHGERT 368

  Fly   369 ADEYAGMEPVVEELCVKKVAPPRFQEPPEEPMVHKVKTQFGQGSGPEDAYSAKSKTLTFPGVSDE 433
            |:|.....|.......::.|.......|.||..|..:|.|           |..||.:....|.|
Human   369 ANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPF-----------ANDKTTSSSAESTE 422

  Fly   434 GSSLEPKTPFSIQQSSFS-TQPSDEGNRIESER--PEPEGEDQIQEVQYTE-DYLRSLDGIKNRP 494
            ...   :||.:.:.::.| .:|::...|..:|.  |.|.|..:.:|....| ..|..::..:||.
Human   423 HGE---RTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTLSPVEPTENRE 484

  Fly   495 LMRED----------GSGRRRAFKKRRSSGSSNSSRESRASRDEELKMFTSLEEEELRHGDR--- 546
            ....:          .:|:|..|...:::.||                     .|...||:|
Human   485 TTANEKTTPSPAEPTENGQRTPFANEKTTSSS---------------------AEPTEHGERTPL 528

  Fly   547 EDYNPIKYTSEPTLRVKSHRRHKRSPAKDVRPTAESTTSLEM--LGEESTNPWGEVVPEHYKDTE 609
            .:.|.....:|||     ..|.:.:..|.....||.|.:.:.  |..|.|.|......|:.:.|.
Human   529 ANENTTPSPAEPT-----ENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP 588

  Fly   610 FWKREKALSIDEEEIELER----------PSRGEDVE--EEATNEPKSSSFEEATEAQNEQAVAA 662
            | ..||..|...|..|.|.          ||..|..|  |...||..:.|  .|...:|.:..|.
Human   589 F-ANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPS--PAGPTENREMTAN 650

  Fly   663 LKQQLSKEQLDKEAEKD-NPQAVDTSDSNKSNLQTSIAAEEQSRGGSPGLRRSPRMDEMEHYPER 726
            .|..|...:..:..|:. |.:...:......|.|.:..|.|::...|.         |...:.||
Human   651 EKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSSSA---------EPTEHGER 706

  Fly   727 WSASQEQQSVQQQPP-----RTAPAINVQQPDTAPWRDQYGLLMEGLSDFYDFTASVNPSRSRSA 786
            ...:.|..::....|     |||      ...|.|                 |.|....:|.|:|
Human   707 TPLANENTTLSPAEPTENRERTA------NEKTTP-----------------FPAEPTENRERTA 748

  Fly   787 SRNPSPAPKNVANLMDGDTERSLEVYDDTQEGVMAGELNCESVLQLLESNLNETESTNDQLQVQT 851
            :.|.:|:|.                 ..|:.|                   :.|...|:: ...:
Human   749 NENTTPSPA-----------------QPTENG-------------------DRTPLANEK-TTPS 776

  Fly   852 VADDARDGKSILPMVHEPLESSALGAVLEERGREPS--VGRIQSRSRSRSRSPLPTSENLEKSIH 914
            :|:...:||. .|..:|...||:         .||:  ..|....:.:.:.||...:||.|::.:
Human   777 LAEPTENGKR-TPFANEKTTSSS---------AEPTEHAERTPLANENTTSSPAEPTENRERTAN 831

  Fly   915 KRRERLIKQNDELAERLSH-------SSPEDSMEIETSDNGRLSPTLEVTLPQPVIEINEMADEP 972
            ::..:...:..|..|..::       :.|.::.|...::|..|||.      :|. |..||.  |
Human   832 EKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPA------EPT-EHEEMT--P 887

  Fly   973 MEDAETT--PEEMRLFVETLRAERNARSRSRSRSRSPLPTAGNIEKSLESR-----RLKRIQHND 1030
            :.:.:||  |.|     .|...||...:..::...|..||.......|.:.     |.:..:|.:
Human   888 LANEKTTLSPAE-----PTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSRAEPTEHGE 947

  Fly  1031 EIF-EKLHDQMSSP-----QIIIESASPPSLPLPLPTISIEIAEPPEENASHTEAEPEDTPESMA 1089
            .|. ||.....:.|     ..:.|..:|.|            || |.||...|....|:|..|..
Human   948 RIANEKATPSPAKPTEHGETTVNEDTTPSS------------AE-PTENGERTPLANENTTTSPT 999

  Fly  1090 RLFEQLRLNRVRSHSRSRSRSPLPTPANLEQSVQKRRERLIAQNDQFFEVLQERARTPEPETRLT 1154
            ...|.        ..|:.:....|:||    ...:..||..:.|::         ..|.|..
Human  1000 ESTEH--------GERTANEKTTPSPA----EPTEHGERTPSANEK---------TIPSPAK--- 1040

  Fly  1155 VEYVYEYVQEKDEQVGEGRDKRSLSPSRSRSQSQEKALDDFHLMLNLEGSELRTLRKNSEELESV 1219
                   ..|.:|......:..:.||.:.....::..|.:..:.|:.||.        :|.
Human  1041 -------PTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGP--------TEH---- 1086

  Fly  1220 LAVGAKQREVDMDALEKLHNANEEIELRVLSPTNSELERVVEMTRENPDMDRTVSEVARDLQDEL 1284
               |||..           :|||:|...:..||...              :||.|.     .|::
Human  1087 ---GAKTT-----------SANEKITPSLAKPTEHG--------------ERTTSP-----NDKI 1118

  Fly  1285 MASGFKRSTYVGESLDLGSDQFKELRREAAQFQRSRSPSPGSSMDYAREQAAAQRELQTAILDSL 1349
            .:|       ..||.:         .|:.|......:|:|...:.:|:....| .|..|.:.:..
Human  1119 TSS-------AAESTE---------HRDRATSANVITPAPAEPIKHAKRTTLA-HEKMTQVTEKS 1166

  Fly  1350 TE------------SRLGAKPKTYSEE---RTGEFEDISAAQLDDLRHRTAEFQRSRSQSRS--- 1396
            ||            :|...||..|||:   ..|:...:.....::|.:.|...:..::..:|
Human  1167 TEHPEKTTSTTEKTTRTPEKPTLYSEKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTEN 1231

  Fly  1397 PLREVELTQ-------------LRDIEAESAKRELQDQ--------LLDRLAASSINFE---NFS 1437
            |.:...:|:             |....:...|.|:..|        :..|...|||..|   |.|
Human  1232 PEKTAAVTKTIKPSVKVTGDKSLTTTSSHLNKTEVTHQVPTGSFTLITSRTKLSSITSEATGNES 1296

  Fly  1438 R-HLNADFLDSERRASDSALMGD 1459
            . :||.   |..::...:..||:
Human  1297 HPYLNK---DGSQKGIHAGQMGE 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmpt	NP_996113.2	GBP_C	<103..201	CDD:303769	15/71 (21%)
		ARGLU	110..255	CDD:291991	21/129 (16%)
		coiled coil	170..181	CDD:293879	1/14 (7%)
		coiled coil	190..201	CDD:293879	3/11 (27%)
MUCL3	NP_543146.2	Atrophin-1	<299..820	CDD:331285	127/650 (20%)
MUCL3	NP_543146.2	LGT	<916..1062	CDD:320995	36/189 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900