Protein Alignment Rh4 and OPN1MW2

DIOPT Version :10

• Sequence 1: NP_476701.1
• Gene: Rh4 / 39887
• FlyBaseID: FBgn0003250
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_001041646.1
• Gene: OPN1MW2 / 728458
• HGNCID: 26952
• Length: 364
• Species: Homo sapiens
• Alignment Length: 122
• Identity: 28/122 - (22%)
• Similarity: 41/122 - (33%)
• Gaps: 37/122 - (30%)

  Fly    43 SELSFLSSLSSDPSPKPLSVNIGHIESVVRILQLPSITGVSRVCKPIPLPIGGVHVDLVCTLGKV 107
            ||||..|.....|||..              ..:|..:|:|.:.:...||..|..:.::.:||.
Human   437 SELSRTSGFHLIPSPPK--------------YPMPPESGISSLGRSADLPFRGRRLRVLGSLGP- 486

  Fly   108 PVWIIVSDRNPRYISWNGDRHGSKGLRSRIEQILAAANSTTTLKPSSVILFFANGLP 164
                                  |.|..|.:.:.|||..:...|:.||.....|.|.|
Human   487 ----------------------SLGEGSVLGERLAAVTALRALEASSGPSHRAQGCP 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh4	NP_476701.1	7tmA_photoreceptors_insect	55..345	CDD:320207	23/110 (21%)
		TM helix 1	56..82	CDD:320207	3/25 (12%)
		TM helix 2	89..114	CDD:320207	5/24 (21%)
		TM helix 3	126..156	CDD:320207	9/29 (31%)
		TM helix 4	166..186	CDD:320207
		TM helix 5	214..243	CDD:320207
		TM helix 6	273..303	CDD:320207
		TM helix 7	313..338	CDD:320207
OPN1MW2	NP_001041646.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269|PubMed:30948514	17..43
		7tm_GPCRs	42..333	CDD:475119
		TM helix 1	56..80	CDD:410628
		TM helix 2	89..111	CDD:410628
		TM helix 3	127..149	CDD:410628
		TM helix 4	171..187	CDD:410628
		TM helix 5	217..240	CDD:410628
		TM helix 6	267..289	CDD:410628
		TM helix 7	301..326	CDD:410628