Protein Alignment Rh4 and RHO

DIOPT Version :10

• Sequence 1: NP_476701.1
• Gene: Rh4 / 39887
• FlyBaseID: FBgn0003250
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_000530.1
• Gene: RHO / 6010
• HGNCID: 10012
• Length: 348
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 93/343 - (27%)
• Similarity: 143/343 - (41%)
• Gaps: 42/343 - (12%)

  Fly    38 YIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLI 102
            |:.|.|         ...||..:...|.......|.:.:::....|.||||.|..:|||||.||.
Human    30 YLAEPW---------QFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLF 85

  Fly   103 MCLKA-PIFIYNSFHRGFALGNTWCQI---FASIGSYSGIGAGMTNAAIGYDRYNVITKPMNRNM 163
            |.|.. ...:|.|.|..|..|.|.|.:   ||::|   |..|..:...:..:||.|:.|||: |.
Human    86 MVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG---GEIALWSLVVLAIERYVVVCKPMS-NF 146

  Fly   164 TF--TKAVIMNIIIWLYCTPWVVLPLTQFWDRFVPEGYLTSCSFDY--LSDNFDTRLFVGTIFFF 224
            .|  ..|::.....|:........||.. |.|::|||...||..||  |....:...||..:|..
Human   147 RFGENHAIMGVAFTWVMALACAAPPLAG-WSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVV 210

  Fly   225 SFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMNVESLRSNVDKSKETAEIRIAKAAITICFLF 289
            .|..|.::|.:.|.|:   ||:.::|..:|.:....:.           ||..:.:..|.:...|
Human   211 HFTIPMIIIFFCYGQL---VFTVKEAAAQQQESATTQK-----------AEKEVTRMVIIMVIAF 261

  Fly   290 FVSWTPYGVMSLIGAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYR-LELQKRC---- 349
            .:.|.||..::........|...|....|||...|..|..:|.:|.:.:.::| ..|...|
Human   262 LICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKN 326

  Fly   350 PWLGVNEKSGEISSAQST 367
            | ||.:|.|..:|..:::
Human   327 P-LGDDEASATVSKTETS 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh4	NP_476701.1	7tmA_photoreceptors_insect	55..345	CDD:320207	82/298 (28%)
		TM helix 1	56..82	CDD:320207	4/25 (16%)
		TM helix 2	89..114	CDD:320207	11/25 (44%)
		TM helix 3	126..156	CDD:320207	9/32 (28%)
		TM helix 4	166..186	CDD:320207	2/19 (11%)
		TM helix 5	214..243	CDD:320207	8/28 (29%)
		TM helix 6	273..303	CDD:320207	7/29 (24%)
		TM helix 7	313..338	CDD:320207	8/24 (33%)
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	3/15 (20%)
		7tmA_MWS_opsin	38..317	CDD:381742	82/297 (28%)
		TM helix 1	39..65	CDD:381742	4/25 (16%)
		TM helix 2	72..99	CDD:381742	11/26 (42%)
		TM helix 3	110..140	CDD:381742	9/32 (28%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343	134..136		0/1 (0%)
		TM helix 4	151..173	CDD:381742	3/21 (14%)
		TM helix 5	200..230	CDD:381742	10/32 (31%)
		TM helix 6	245..275	CDD:381742	7/40 (18%)
		TM helix 7	285..310	CDD:381742	8/24 (33%)
		Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425	330..348		3/14 (21%)