DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh4 and Opn4

DIOPT Version :9

Sequence 1:	NP_476701.1	Gene:	Rh4 / 39887	FlyBaseID:	FBgn0003250	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_038915.1	Gene:	Opn4 / 30044	MGIID:	1353425	Length:	521	Species:	Mus musculus

Alignment Length:	393	Identity:	123/393 - (31%)
Similarity:	193/393 - (49%)	Gaps:	43/393 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EPPLRPEARSSGNGDLQFLG-------WN-------------VPPDQIQYIPEHWL--TQLEPPA 51
            :.|..|...||...|..|..       ||             |.|....:....|:  ..::.|.
Mouse     2 DSPSGPRVLSSLTQDPSFTTSPALQGIWNGTQNVSVRAQLLSVSPTTSAHQAAAWVPFPTVDVPD 66

  Fly    52 SMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCL-KAPIFIYNSF 115
            ..||.||...:.:.....:||..||:.|..::.||||:|||::||||.|.:|.: :||:|..:|.
Mouse    67 HAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMFIINLAVSDFLMSVTQAPVFFASSL 131

  Fly   116 HRGFALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPM---NRNMTFTKAVIMNIIIWL 177
            ::.:..|.|.|:.:|..|:..||.:.:|..||..|||.|||:|:   .|......|::: :.:||
Mouse   132 YKKWLFGETGCEFYAFCGAVFGITSMITLTAIAMDRYLVITRPLATIGRGSKRRTALVL-LGVWL 195

  Fly   178 YCTPWVVLPLTQFWDRFVPEGYLTSCSFDYLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVG 242
            |...|.:.|... |..:||||.|||||:||::.....|.:...:|.|.|..|.|:|::.|..|.
Mouse   196 YALAWSLPPFFG-WSAYVPEGLLTSCSWDYMTFTPQVRAYTMLLFCFVFFLPLLIIIFCYIFIF- 258

  Fly   243 HVFSHEKALREQAKK---MNVESLRSNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGA 304
                  :|:||..:.   .....||......:..:|.::||.|:.:..||.:||.||..::|:..
Mouse   259 ------RAIRETGRACEGCGESPLRQRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAF 317

  Fly   305 FGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGV-----NEKSGEISSA 364
            .|...:|||..:.:||...|..|..:|.:|||:||:||:.:.:..|.|||     .::|....|.
Mouse   318 AGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSGQRSHPSLSY 382

  Fly   365 QST 367
            :||
Mouse   383 RST 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh4	NP_476701.1	7tmA_photoreceptors_insect	55..345	CDD:320207	102/296 (34%)
		TM helix 1	57..81	CDD:320207	7/23 (30%)
		TM helix 2	90..111	CDD:320207	11/21 (52%)
		TM helix 3	127..149	CDD:320207	7/21 (33%)
		TM helix 4	170..186	CDD:320207	4/15 (27%)
		TM helix 5	215..238	CDD:320207	7/22 (32%)
		TM helix 6	279..301	CDD:320207	9/21 (43%)
		TM helix 7	313..338	CDD:320207	9/24 (38%)
Opn4	NP_038915.1	7tm_4	77..>244	CDD:304433	61/168 (36%)
		7tm_1	86..347	CDD:278431	92/269 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCHK
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42416
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24240
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840