DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13029 and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_648928.1	Gene:	CG13029 / 39886	FlyBaseID:	FBgn0036670	Length:	288	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	233	Identity:	60/233 - (25%)
Similarity:	93/233 - (39%)	Gaps:	54/233 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 IAWLMALFIV-------------------YNLLGNMLACHR--NSSAVTSLPKDRQI-------P 96
            :|||:.||..                   |..:|.:.|.|.  :.:||:..|.|..:       |
Human    54 VAWLLYLFFAVIGFGILVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYAGP 118

  Fly    97 CP-----------EEKHLWHFCDHCQMLVPPRSWHCKVCECCILRRDHHCIFTATCVGHTNYRYF 150
            .|           |:.|    |:.|.:.|..||.||..|..|:...||||.:...|||..|||.|
Human   119 LPIFNRSQHAHVIEDLH----CNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLF 179

  Fly   151 FWFTVYMHIGSLL--SLATHVNLLIIDEQIR----RQYVVL--HFSRFFLFL--KPMSCELIALN 205
            ........:|.||  .:||:|.:......:|    |.:.||  |...:|:||  .|:..:..|:.
Human   180 LHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFEVLKNHTDVWFVFLPAAPVETQAPAIL 244

  Fly   206 ISFIINIYACILSLIMLGYQIPALYLNTTFYTPKDYRY 243
            ....:.|...:||..:||:.: ..::...::....|.|
Human   245 ALAALLILLGLLSTALLGHLL-CFHIYLMWHKLTTYEY 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13029	NP_648928.1	zf-DHHC	100..236	CDD:279823	42/145 (29%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		58/221 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		zf-DHHC	129..284	CDD:307600	45/158 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810