DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sinah and TRAF6

DIOPT Version :9

Sequence 1:NP_648927.1 Gene:sinah / 39885 FlyBaseID:FBgn0259794 Length:351 Species:Drosophila melanogaster
Sequence 2:NP_004611.1 Gene:TRAF6 / 7189 HGNCID:12036 Length:522 Species:Homo sapiens


Alignment Length:142 Identity:37/142 - (26%)
Similarity:55/142 - (38%) Gaps:29/142 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 RKDSVAVQSGIVATGPLDTT----RSGARDDF---LMALLECPVCFGYIMPPIMQCPRGHLICST 129
            :.|||   .|..:||.|.::    ..|...:|   |.:..|||:|. ..:...:|.|.||..|..
Human    32 KDDSV---GGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICL-MALREAVQTPCGHRFCKA 92

  Fly   130 C-----RSKLTICPV-------CRVFMTNIRSLAMEKVASKLIFPCKHSHFGCRARLSYAEKTKH 182
            |     |.....|||       .::|..|   .|..::.| |:..|.:.  ||..::.......|
Human    93 CIIKSIRDAGHKCPVDNEILLENQLFPDN---FAKREILS-LMVKCPNE--GCLHKMELRHLEDH 151

  Fly   183 EEDCECRPYFCP 194
            :..||.....||
Human   152 QAHCEFALMDCP 163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sinahNP_648927.1 zf-C3HC4 106..140 CDD:278524 13/45 (29%)
Sina 147..341 CDD:281181 11/48 (23%)
TRAF6NP_004611.1 Interaction with TAX1BP1. /evidence=ECO:0000269|PubMed:10920205 1..354 37/142 (26%)
RING 69..107 CDD:238093 12/38 (32%)
zf-TRAF 204..261 CDD:280357
MATH_TRAF6 351..500 CDD:239745
Interaction with TANK. /evidence=ECO:0000269|PubMed:25861989 355..522
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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