Protein Alignment sinah and SIAH1

DIOPT Version :10

• Sequence 1: NP_648927.1
• Gene: sinah / 39885
• FlyBaseID: FBgn0259794
• Length: 351
• Species: Drosophila melanogaster
• Sequence 2: NP_001006611.1
• Gene: SIAH1 / 6477
• HGNCID: 10857
• Length: 313
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 137/324 - (42%)
• Similarity: 193/324 - (59%)
• Gaps: 26/324 - (8%)

  Fly    32 LTRRQSAPAL---------VVPPEETTHVVVVKRQSPDAAAAG--ELVPSRRKDSVAVQSGIVAT 85
            :|.:.:.|:|         .:|...|.....:.||:..|...|  :..||:|..::
Human     1 MTGKATPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRVPAL--------- 56

  Fly    86 GPLDTTRSGARDDFLMALLECPVCFGYIMPPIMQCPRGHLICSTCRSKLTICPVCRVFMTNIRSL 150
                 |.:.|.::.|.:|.||||||.|::|||:||..|||:||.||.|||.||.||..:.:||:|
Human    57 -----TGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNL 116

  Fly   151 AMEKVASKLIFPCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMS 215
            ||||||:.::||||::..||...|.:.||..|||.||.|||.||.|...|.|||.|..|..|||.
Human   117 AMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMH 181

  Fly   216 SHENVITMEGNDIIFLATNVNLEGALDWTMVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIGSM 280
            .|:::.|::|.||:||||::||.||:||.|:|||.|.||:|.|||....:..||:|...::||:.
Human   182 QHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTR 246

  Fly   281 KDAAEFVYNISLEAYNRTLRWQSKPRSIRENF-SSFTNADFLVLNKHTVELFSEDGNLALNVVI 343
            |.|..|.|.:.|..:.|.|.|::.||||.|.. ::..|:|.||.:....:||:|:|||.:||.|
Human   247 KQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTI 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sinah	NP_648927.1	RING_Ubox	102..151	CDD:473075	29/48 (60%)
		Sina	147..341	CDD:460824	92/194 (47%)
SIAH1	NP_001006611.1	RING-HC_SIAH2	67..117	CDD:438410	29/49 (59%)
		Sina	113..309	CDD:460824	93/195 (48%)