DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sinah and SIAH1

DIOPT Version :9

Sequence 1:	NP_648927.1	Gene:	sinah / 39885	FlyBaseID:	FBgn0259794	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_001006611.1	Gene:	SIAH1 / 6477	HGNCID:	10857	Length:	313	Species:	Homo sapiens

Alignment Length:	324	Identity:	137/324 - (42%)
Similarity:	193/324 - (59%)	Gaps:	26/324 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LTRRQSAPAL---------VVPPEETTHVVVVKRQSPDAAAAG--ELVPSRRKDSVAVQSGIVAT 85
            :|.:.:.|:|         .:|...|.....:.||:..|...|  :..||:|..::
Human     1 MTGKATPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRVPAL--------- 56

  Fly    86 GPLDTTRSGARDDFLMALLECPVCFGYIMPPIMQCPRGHLICSTCRSKLTICPVCRVFMTNIRSL 150
                 |.:.|.::.|.:|.||||||.|::|||:||..|||:||.||.|||.||.||..:.:||:|
Human    57 -----TGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNL 116

  Fly   151 AMEKVASKLIFPCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMS 215
            ||||||:.::||||::..||...|.:.||..|||.||.|||.||.|...|.|||.|..|..|||.
Human   117 AMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMH 181

  Fly   216 SHENVITMEGNDIIFLATNVNLEGALDWTMVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIGSM 280
            .|:::.|::|.||:||||::||.||:||.|:|||.|.||:|.|||....:..||:|...::||:.
Human   182 QHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTR 246

  Fly   281 KDAAEFVYNISLEAYNRTLRWQSKPRSIRENF-SSFTNADFLVLNKHTVELFSEDGNLALNVVI 343
            |.|..|.|.:.|..:.|.|.|::.||||.|.. ::..|:|.||.:....:||:|:|||.:||.|
Human   247 KQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTI 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sinah	NP_648927.1	zf-C3HC4	106..140	CDD:278524	23/33 (70%)
sinah	NP_648927.1	Sina	147..341	CDD:281181	92/194 (47%)
SIAH1	NP_001006611.1	RING-HC_SIAH1	70..109	CDD:319665	26/38 (68%)
		RING-HC finger (C3HC4-type)	72..106	CDD:319665	23/33 (70%)
		Sina	113..309	CDD:367355	93/195 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60089
OrthoDB	1	1.010	-	-		D780610at2759
OrthoFinder	1	1.000	-	-		FOG0001170
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104798
Panther	1	1.100	-	-	O	PTHR45877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X796
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.790