DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sinah and siah2l

DIOPT Version :9

Sequence 1:	NP_648927.1	Gene:	sinah / 39885	FlyBaseID:	FBgn0259794	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_956721.2	Gene:	siah2l / 378728	ZFINID:	ZDB-GENE-030922-1	Length:	330	Species:	Danio rerio

Alignment Length:	295	Identity:	133/295 - (45%)
Similarity:	179/295 - (60%)	Gaps:	9/295 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SPDAAAAGELVPSRRKDSVAVQSGIVATG-------PLDTTRSGARDDFLMALLECPVCFGYIMP 115
            |..||||.....:....:..|...:..:|       .|.......:...|.||.||||||.|::|
Zfish    33 SAAAAAAAAAAAAAAAAAAGVSGSVAGSGTVPAAAVALPVAALPGQSPELTALFECPVCFDYVLP 97

  Fly   116 PIMQCPRGHLICSTCRSKLTICPVCRVFMT-NIRSLAMEKVASKLIFPCKHSHFGCRARLSYAEK 179
            ||:||..|||:|:.||.||:.||.||..:| :||:||||||||.|.||||:|..||...|.::||
Zfish    98 PILQCQAGHLVCNQCRQKLSCCPTCRGPLTPSIRNLAMEKVASTLPFPCKYSSAGCLLSLHHSEK 162

  Fly   180 TKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMSSHENVITMEGNDIIFLATNVNLEGALDWT 244
            .:|||.||.|||.||.|...|.|||.|.:|..|||.:|:::.|::|.||:||||::||.||:||.
Zfish   163 PEHEEVCEFRPYTCPCPGASCKWQGSLEEVMPHLMHAHKSITTLQGEDIVFLATDINLPGAVDWV 227

  Fly   245 MVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIGSMKDAAEFVYNISLEAYNRTLRWQSKPRSIR 309
            |:|||.|.||:|.|||....|..||:|....:||:.|.|..|.|.:.|....|.|.|::.||||.
Zfish   228 MMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIH 292

  Fly   310 ENF-SSFTNADFLVLNKHTVELFSEDGNLALNVVI 343
            :.. ::..|:|.||.:.....||:::|||.:||.|
Zfish   293 DGVAAAIMNSDCLVFDTSIAHLFADNGNLGINVTI 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sinah	NP_648927.1	zf-C3HC4	106..140	CDD:278524	21/33 (64%)
sinah	NP_648927.1	Sina	147..341	CDD:281181	94/194 (48%)
siah2l	NP_956721.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sina	130..326	CDD:281181	95/195 (49%)
		SBD	138..330		90/190 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60089
OrthoDB	1	1.010	-	-		D780610at2759
OrthoFinder	1	1.000	-	-		FOG0001170
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X796
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.890