DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sinah and ADAM2

DIOPT Version :9

Sequence 1:	NP_648927.1	Gene:	sinah / 39885	FlyBaseID:	FBgn0259794	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_001455.3	Gene:	ADAM2 / 2515	HGNCID:	198	Length:	735	Species:	Homo sapiens

Alignment Length:	364	Identity:	66/364 - (18%)
Similarity:	121/364 - (33%)	Gaps:	147/364 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SAPALVVPPEETTHVVVVKRQSPDAAAAGELVPSRRKDSVAVQ--------------SGIVATGP 87
            |.|..:..||:...::   ::..::.|:.::|...:..:|.:.              ||.....|
Human    22 SLPVQITVPEKIRSII---KEGIESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKP 83

  Fly    88 LDTTRSGARDDF-----LMALLECPVCFGYIMPPIMQCPRGHLICSTCRSKLTICPVCRVFMTNI 147
            ||       .||     ....:|     ||        |:..::.|||              |.:
Human    84 LD-------QDFQNFCHYQGYIE-----GY--------PKSVVMVSTC--------------TGL 114

  Fly   148 RS-LAMEKVA------------SKLIFPCKHSHFGCRARLS-YAEKTKHEED-------CECRPY 191
            |. |..|.|:            ..:|:..||.    :|.:| |.||.....|       .|.:..
Human   115 RGVLQFENVSYGIEPLESSVGFEHVIYQVKHK----KADVSLYNEKDIESRDLSFKLQSVEPQQD 175

  Fly   192 FCPYPDDKCSWQGPLRDVYQHLMSS----HENVITMEG-NDIIFLATNVNLEGALDWTMVQSCHG 251
            |..|.:.....:   :.:|.|:.|.    .:.|..:.| .:.||::.|:.:
Human   176 FAKYIEMHVIVE---KQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITI-------------- 223

  Fly   252 RHFLLSLEKINLGEDCQQYFTACRMIGSMKDAAEFVYNISLEAYNRTLRWQS-----KPRSI--- 308
               :||..::.:.|:         .|.:..:|.|.::..        |||::     :|..:
Human   224 ---ILSSLELWIDEN---------KIATTGEANELLHTF--------LRWKTSYLVLRPHDVAFL 268

  Fly   309 ---RENFSSFTNADF------------LVLNKHTVELFS 332
               ||. |::..|.|            :||:..|:.|.|
Human   269 LVYREK-SNYVGATFQGKMCDANYAGGVVLHPRTISLES 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sinah	NP_648927.1	zf-C3HC4	106..140	CDD:278524	6/33 (18%)
sinah	NP_648927.1	Sina	147..341	CDD:281181	44/235 (19%)
ADAM2	NP_001455.3	Pep_M12B_propep	42..140	CDD:279848	22/131 (17%)
		Reprolysin	178..375	CDD:279729	29/167 (17%)
		ZnMc_adamalysin_II_like	178..373	CDD:239797	29/167 (17%)
		DISIN	393..470	CDD:214490
		ACR	472..609	CDD:214743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11711
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950