DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sinah and TRIM50

DIOPT Version :9

Sequence 1:	NP_648927.1	Gene:	sinah / 39885	FlyBaseID:	FBgn0259794	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_001268380.1	Gene:	TRIM50 / 135892	HGNCID:	19017	Length:	487	Species:	Homo sapiens

Alignment Length:	195	Identity:	44/195 - (22%)
Similarity:	72/195 - (36%)	Gaps:	56/195 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LECPVCFGYIMPPIM-QCPRGHLICSTCRSKLTI-------CPVCRVFM---TNIRSLAMEKVAS 157
            |:||:|......|:| ||  ||..|..|...|:.       |||||..:   :::.::::.:|..
Human    14 LQCPICLEVFKEPLMLQC--GHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNVSLARVIE 76

  Fly   158 KLIFP-------CKHSHFGCRARLS-YAEKTKHEEDCECRPYFCPYPDDKCSWQG--------PL 206
            .|..|       |.|.    |..|| :.||   :::..|         ..|...|        |:
Human    77 ALRLPGDPEPKVCVHH----RNPLSLFCEK---DQELIC---------GLCGLLGSHQHHPVTPV 125

  Fly   207 RDVYQHLMSSHENVIT------MEGNDIIFLATN-----VNLEGALDWTMVQSCHGRHFLLSLEK 260
            ..||..:......:|:      .:.:::|....|     ||......|.:.:.....|.|:..||
Human   126 STVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELHHLVDEEK 190

Fly 261 260
Human 191 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sinah	NP_648927.1	zf-C3HC4	106..140	CDD:278524	14/41 (34%)
sinah	NP_648927.1	Sina	147..341	CDD:281181	26/141 (18%)
TRIM50	NP_001268380.1	RING-HC_TRIM50_like_C-IV	14..58	CDD:319519	17/45 (38%)
		RING-HC finger (C3HC4-type)	16..56	CDD:319519	14/41 (34%)
		BBOX	90..125	CDD:237988	9/50 (18%)
		SPRY_PRY_TRIM50	283..469	CDD:293977
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910