Protein Alignment sina and SIAH3

DIOPT Version :10

• Sequence 1: NP_476725.1
• Gene: sina / 39884
• FlyBaseID: FBgn0003410
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_942146.2
• Gene: SIAH3 / 283514
• HGNCID: 30553
• Length: 269
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 105/266 - (39%)
• Similarity: 145/266 - (54%)
• Gaps: 43/266 - (16%)

  Fly    76 CFDYVLPPI-----------LQCSSGHLVCVSCRSKLTCCPTCRGPLANIRNLAMEKVASNVKFP 129
            ||..||..|           :..::|.||||.            .|..|::.::..:..:. ..|
Human     7 CFGAVLDLIHLRFQHYKAKRVFSAAGQLVCVV------------NPTHNLKYVSSRRAVTQ-SAP 58

  Fly   130 --------------CKHSGYGCTASLVYTEKTEHEE----TCECRPYLCPCPGASCKWQGPLDLV 176
                          |.|..:.......:.....|:|    .....|.||.||..||:|:|.|::|
Human    59 EQGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHANPVTPCLCMCPLFSCQWEGRLEVV 123

  Fly   177 MQHLMMSHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFFAIV 241
            :.||...|: :..|||.:|||||||::||...||::|.||.||||:|||.|||:::||.||||.:
Human   124 VPHLRQIHR-VDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQERHEGHPQFFATM 187

  Fly   242 QLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFADNGNLG 306
            .|||:..:|:.|.||||||.|.|||.|||.|||:.|.|.|.|.:.||||.:||:||||:|||:|.
Human   188 MLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLVLNTSLAQLFSDNGSLA 252

  Fly   307 INVTIS 312
            |.:.|:
Human   253 IGIAIT 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sina	NP_476725.1	RING_Ubox	68..118	CDD:473075	12/52 (23%)
		Sina	114..310	CDD:460824	92/213 (43%)
SIAH3	NP_942146.2	Sina	133..259	CDD:239753	74/126 (59%)