Protein Alignment sina and Siah2

DIOPT Version :10

• Sequence 1: NP_476725.1
• Gene: sina / 39884
• FlyBaseID: FBgn0003410
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_033200.2
• Gene: Siah2 / 20439
• MGIID: 108062
• Length: 325
• Species: Mus musculus
• Alignment Length: 305
• Identity: 222/305 - (72%)
• Similarity: 247/305 - (80%)
• Gaps: 15/305 - (4%)

  Fly    12 PTAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSSSSLSSAGGGDAGMSA---DLTSLFEC 73
            |:.||..|.||           .|:||..|||..::::..|...||||...:|.   :|||||||
Mouse    28 PSPAAPPAAAT-----------ISAAGPGSSAVPAAAAVISGPGAGGGADPVSPQHHELTSLFEC 81

  Fly    74 PVCFDYVLPPILQCSSGHLVCVSCRSKLTCCPTCRGPLA-NIRNLAMEKVASNVKFPCKHSGYGC 137
            ||||||||||||||.:|||||..||.||:|||||||.|. :|||||||||||.|.||||::..||
Mouse    82 PVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGC 146

  Fly   138 TASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDI 202
            :.:|.:|||.|||:.||.|||.||||||||||||.|:.||.|||.:|||||||||||||||||||
Mouse   147 SLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDI 211

  Fly   203 NLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLT 267
            |||||||||||||||||||||||||||||:|||||||||.|||:||:||||.|||||||||||||
Mouse   212 NLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLT 276

  Fly   268 WEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFADNGNLGINVTIS 312
            |||.|||||:|||:||.|||||||||:||.|||||||||||||||
Mouse   277 WEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTIS 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sina	NP_476725.1	RING_Ubox	68..118	CDD:473075	40/50 (80%)
		Sina	114..310	CDD:460824	162/195 (83%)
Siah2	NP_033200.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		7/25 (28%)
		RING-HC_SIAH2	76..126	CDD:438410	39/49 (80%)
		Sina	123..319	CDD:460824	162/195 (83%)
		SBD. /evidence=ECO:0000250|UniProtKB:P61092	131..323		158/191 (83%)