DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sina and Siah1a

DIOPT Version :9

Sequence 1:	NP_001287089.1	Gene:	sina / 39884	FlyBaseID:	FBgn0003410	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	XP_006530847.3	Gene:	Siah1a / 20437	MGIID:	108064	Length:	355	Species:	Mus musculus

Alignment Length:	297	Identity:	219/297 - (73%)
Similarity:	237/297 - (79%)	Gaps:	25/297 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ATGVATNTSTSTGS----SSAGNTSSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVL 81
            ||.:.|.||....|    :..|.|:|.|                     ||.|||||||||||||
Mouse    79 ATALPTGTSKCPPSQRVPALTGTTASNN---------------------DLASLFECPVCFDYVL 122

  Fly    82 PPILQCSSGHLVCVSCRSKLTCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEK 146
            ||||||.||||||.:||.||||||||||||.:||||||||||::|.||||::..||..:|.:|||
Mouse   123 PPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEK 187

  Fly   147 TEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVDWV 211
            .||||.||.|||.||||||||||||.||.||.|||..||||||||||||||||||||||||||||
Mouse   188 AEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWV 252

  Fly   212 MMQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSIH 276
            |||||||.||||||||||||||||||||||||||:||:||||.|||||||:||||||||.|||||
Mouse   253 MMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIH 317

  Fly   277 EGVASAIHNSDCLVFDTSIAQLFADNGNLGINVTISL 313
            ||:|:||.||||||||||||||||:|||||||||||:
Mouse   318 EGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISM 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sina	NP_001287089.1	Sina	114..310	CDD:281181	164/195 (84%)
Siah1a	XP_006530847.3	RING-HC_SIAH1	112..151	CDD:319665	34/38 (89%)
Siah1a	XP_006530847.3	Sina	155..351	CDD:367355	164/195 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	349	1.000	Domainoid score	I1022
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20654
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1604
Isobase	1	0.950	-	0	Normalized mean entropy	S1969
OMA	1	1.010	-	-		QHG60089
OrthoDB	1	1.010	-	-		D780610at2759
OrthoFinder	1	1.000	-	-		FOG0001170
OrthoInspector	1	1.000	-	-		otm43660
orthoMCL	1	0.900	-	-		OOG6_104798
Panther	1	1.100	-	-	LDO	PTHR45877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2793
SonicParanoid	1	1.000	-	-		X796
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820