DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TSG101 and ELC

DIOPT Version :9

Sequence 1:	NP_524120.1	Gene:	TSG101 / 39881	FlyBaseID:	FBgn0036666	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001327160.1	Gene:	ELC / 820419	AraportID:	AT3G12400	Length:	440	Species:	Arabidopsis thaliana

Alignment Length:	447	Identity:	115/447 - (25%)
Similarity:	186/447 - (41%)	Gaps:	98/447 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAVEETQITKYL---------SKYKYVAATK----KDVVDVVTSFRSLTYDLQRFVFNDGSSKEL 53
            |.....|:.::|         |...|..:.|    :.::::::|:.||......|:.|||.|..|
plant     4 PPSNPQQVQQFLSSALSQRGPSSVPYEESNKWLIRQHLLNLISSYPSLEPKTASFMHNDGRSVNL 68

  Fly    54 FTIQGTIPVVYKNNTYYIPICIWLMDTHPQNAPMCFVKPTPTMQIK-VSMYVDHNGKVYLPYLHD 117
            ....||||:.:...||.||:.|||::::|::.|..:|.||..|.|| ...:|..:|.|.||||.:
plant    69 LQADGTIPMPFHGVTYNIPVIIWLLESYPRHPPCVYVNPTADMIIKRPHAHVTPSGLVSLPYLQN 133

  Fly   118 WQPHSSDLLSLIQVMIVTFGDHPPVYSKPKEQIAAPYPTNSYMPQPGAPGGSNSFLPYPTAGGAG 182
            |...||:|:.|:..:...|...||:||:.:.|...|.|...|......|..::..||.|
plant   134 WVYPSSNLVDLVSDLSAAFARDPPLYSRRRPQPPPPSPPTVYDSSLSRPPSADQSLPRP------ 192

  Fly   183 GSNFPPYPTGSNVGPYPPTPAGPAGGSGYPAYPNFIQPTAGGYPPAAGYNPSNPSSTGTITEEHI 247
               |||.|.|..|                                          |...:...|.
plant   193 ---FPPSPYGGGV------------------------------------------SRVQVQHVHH 212

  Fly   248 KASIISAIDDKLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLERE-HIDMQKNISI 311
            :.....|.:...|..:.:.|....:::.::.|.::...|....:.|.::|.|.| :|.:::.:..
plant   213 QQQSDDAAEVFKRNAINKMVEMVHSDLVSMRRAREAEAEELLSLQAGLKRREDELNIGLKEMVEE 277

  Fly   312 LKDKEQELE--------------------KALEDLESAEAINPDEAVTTTAPLYRQLLNAYADEA 356
            .:..||:|:                    |.|.||:      .|.|......|.:|:|...|.:.
plant   278 KETLEQQLQIISMNTDILDSWVRENQGKTKNLVDLD------VDNAFECGDTLSKQMLECTALDL 336

  Fly   357 ATEDAIYYLGEGLRGGVIDLETFLKHVRQLSRKQFILRATMQKCR------QKAGLA 407
            |.|||||.|.:..:.||:..:.:|::||.|||:||..|||..|.|      |.|.:|
plant   337 AIEDAIYSLDKSFQDGVVPFDQYLRNVRLLSREQFFHRATGSKVRAAQMEVQVAAIA 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_524120.1	UEV	22..140	CDD:283415	42/122 (34%)
		ARS2	<149..227	CDD:282772	14/77 (18%)
		TBPIP	<242..353	CDD:284512	23/131 (18%)
		Vps23_core	336..393	CDD:286532	22/56 (39%)
ELC	NP_001327160.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2826
eggNOG	1	0.900	-	-		E1_KOG2391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4584
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1812
OMA	1	1.010	-	-		QHG54978
OrthoDB	1	1.010	-	-		D1435538at2759
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		oto4269
orthoMCL	1	0.900	-	-		OOG6_102944
Panther	1	1.100	-	-	O	PTHR23306
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840