Protein Alignment TSG101 and TSG101

DIOPT Version :10

• Sequence 1: NP_524120.1
• Gene: TSG101 / 39881
• FlyBaseID: FBgn0036666
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_006283.1
• Gene: TSG101 / 7251
• HGNCID: 15971
• Length: 390
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 208/411 - (50%)
• Similarity: 273/411 - (66%)
• Gaps: 31/411 - (7%)

  Fly     3 AVEETQITKYLSKYKYVAATKKDVVDVVTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVYKNN 67
            ||.|:|:.|.:|||||...|.::.|:|:|.::.|...|..:|||||||:||..:.|||||.|:.|
Human     2 AVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGN 66

  Fly    68 TYYIPICIWLMDTHPQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLIQVM 132
            ||.||||:||:||:|.|.|:||||||.:|.||...:||.|||:||||||:|:...||||.|||||
Human    67 TYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVM 131

  Fly   133 IVTFGDHPPVYSKPKEQIAAPY-----PTNSYMPQPGAPGGSNSFLPYPTAGGAGGSNFPPYPTG 192
            ||.|||.|||:|:|......||     |..|||  ||.|||.:   |||       |.:||.|:|
Human   132 IVVFGDEPPVFSRPISASYPPYQATGPPNTSYM--PGMPGGIS---PYP-------SGYPPNPSG 184

  Fly   193 SNVGPYPPTPAGPAGGSGYPAYPNFIQPTAGGYPPAAGYNPSNPSSTGTITEEHIKASIISAIDD 257
            ....||||       |..|||      .|:..||.........||..|||:|:.|:||:|||:.|
Human   185 YPGCPYPP-------GGPYPA------TTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSD 236

  Fly   258 KLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLEREHIDMQKNISILKDKEQELEKA 322
            |||.|::|::::.|||:..|.||:::|.:|..|::.::.||::|..::.|||.:||.|::||..|
Human   237 KLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSA 301

  Fly   323 LEDLESAEAINP-DEAVTTTAPLYRQLLNAYADEAATEDAIYYLGEGLRGGVIDLETFLKHVRQL 386
            ||.:|:....|. ||.:..|||||:|:||.||:|.|.||.|:||||.||.|||||:.||||||.|
Human   302 LEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLL 366

  Fly   387 SRKQFILRATMQKCRQKAGLA 407
            |||||.|||.|||.|:.|||:
Human   367 SRKQFQLRALMQKARKTAGLS 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_524120.1	UEV	22..140	CDD:399041	70/117 (60%)
		PHA03247	<133..241	CDD:223021	42/112 (38%)
		COG4372	<261..>377	CDD:443500	54/116 (47%)
		Vps23_core	336..395	CDD:462803	40/58 (69%)
TSG101	NP_006283.1	UEV	21..139	CDD:399041	70/117 (60%)
		Interaction with CEP55	158..162		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..220		6/21 (29%)
		COG4372	211..>349	CDD:443500	56/138 (41%)
		Vps23_core	316..375	CDD:462803	33/59 (56%)
		PTAP motif	320..323		1/2 (50%)