DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TSG101 and tsg101

DIOPT Version :9

Sequence 1:	NP_524120.1	Gene:	TSG101 / 39881	FlyBaseID:	FBgn0036666	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_031755824.1	Gene:	tsg101 / 394879	XenbaseID:	XB-GENE-6258323	Length:	396	Species:	Xenopus tropicalis

Alignment Length:	420	Identity:	200/420 - (47%)
Similarity:	273/420 - (65%)	Gaps:	43/420 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AVEETQITKYLSKYKYVAATKKDVVDV-VTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVYKN 66
            |:.|.|:.|.|.||||...:.:::::| |..:|.|...:..:|||||||:||.::.|||||.||.
Frog     2 ALSEAQLKKLLGKYKYRDLSVREILNVTVPLYRDLKPIMDSYVFNDGSSRELLSLSGTIPVPYKG 66

  Fly    67 NTYYIPICIWLMDTHPQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLIQV 131
            |||.||||:||:||:|.|.|:||||||.||.||...:||.|||:||||||:|:...||||.|||:
Frog    67 NTYNIPICLWLLDTYPFNPPICFVKPTSTMTIKTGKHVDANGKIYLPYLHEWKHPPSDLLGLIQI 131

  Fly   132 MIVTFGDHPPVYSKPKEQIAAPYPTNSYMPQPGAPGGSNSFLPYPTAGGAGGSNFPPYPTGSNVG 196
            :||.||:.|||:|  :....||||   ..|..|.|  ::|::|         ...||||..::
Frog   132 LIVVFGEEPPVFS--RSTAPAPYP---MYPATGPP--NSSYMP---------GVIPPYPPAAH-- 178

  Fly   197 PYPPTPAGPAGGSGYPAYPNFIQPTAGGYP----------PAAGYNP---SNPSSTGTITEEHIK 248
                 ||.|:|..|:|.|     |.||.||          |.|...|   |.|:..|||.|:.|:
Frog   179 -----PANPSGYGGFPGY-----PPAGQYPQTSGPQIFPQPPAAQPPVTSSGPARDGTIGEDTIR 233

  Fly   249 ASIISAIDDKLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLEREHIDMQKNISILK 313
            ||:|||:.||||.|::|::::.|||:..|.||:::|.:|..|::.::.|||:|..::.|||..|:
Frog   234 ASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLEQEVTEVDKNIETLR 298

  Fly   314 DKEQELEKALEDLES-AEAINPDEAVTTTAPLYRQLLNAYADEAATEDAIYYLGEGLRGGVIDLE 377
            .|::||...:|.:|| :|..:.||.:..|||||:|:||.||:|.|.||.|:||||.||.|||||:
Frog   299 KKDEELGVVVEKMESQSEYRDIDEVIVPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLD 363

  Fly   378 TFLKHVRQLSRKQFILRATMQKCRQKAGLA 407
            .||||||.||||||.|||.|||.|:.|||:
Frog   364 VFLKHVRLLSRKQFQLRALMQKARKTAGLS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_524120.1	UEV	22..140	CDD:283415	67/118 (57%)
		ARS2	<149..227	CDD:282772	25/87 (29%)
		TBPIP	<242..353	CDD:284512	48/111 (43%)
		Vps23_core	336..393	CDD:286532	39/56 (70%)
tsg101	XP_031755824.1	UEV	22..140	CDD:399041	67/117 (57%)
		GrpE	193..>312	CDD:413575	46/118 (39%)
		DUF1640	<242..298	CDD:400241	22/55 (40%)
		Vps23_core	322..381	CDD:401418	40/58 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4274
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4584
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2143
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1435538at2759
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		oto104775
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060