Protein Alignment TSG101 and tsg-101

DIOPT Version :9

• Sequence 1: NP_524120.1
• Gene: TSG101 / 39881
• FlyBaseID: FBgn0036666
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_500364.2
• Gene: tsg-101 / 182474
• WormBaseID: WBGene00015658
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 416
• Identity: 165/416 - (39%)
• Similarity: 237/416 - (56%)
• Gaps: 34/416 - (8%)

  Fly    17 KYVAATKKDVVDVVTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVYKNNTYYIPICIWLMDTH 81
            ||..:.|||::..::.|:.|:.....|:|.||..:..|.::|||||.||...|.||:.::|.|||
 Worm    16 KYADSAKKDIIGALSQFKDLSPGTDTFMFPDGKRRTAFRLKGTIPVYYKGACYNIPVTVYLWDTH 80

  Fly    82 PQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLIQVMIVTFGDHPPVYSKP 146
            |..||:|:|.||.||.||.|.:|:..|||:||||::|:....||..|:|||.:.|.:..||:::.
 Worm    81 PYYAPICYVNPTSTMVIKESEHVNKEGKVFLPYLNEWRFPGYDLSGLLQVMAMVFQEKCPVFARS 145

  Fly   147 KEQIAAPYPTNSYMPQPGAPGGSNSF-LPYPTAGGAGGSNFP-PYPTGSNVGPYPP--TPAGPAG 207
                ||...||:....|.|...::|. .|||::    ....| ||||||...||||  ||...||
 Worm   146 ----AANSATNASATNPSAGSSASSTPTPYPSS----QPTMPTPYPTGSGAAPYPPSSTPYPSAG 202

  Fly   208 GSGYPAYPNFIQPT------AGGYP-PAAGYNPSNP---------------SSTGTITEEHIKAS 250
            ..||..|.|..|.|      :|..| |:|..||:.|               ||.|||..:.|:||
 Worm   203 AMGYNPYMNVPQSTPYPMGASGASPYPSASSNPAPPPPRPPPVTAQTSVSSSSGGTIQADTIRAS 267

  Fly   251 IISAIDDKLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLEREHIDMQKNISILKDK 315
            ::||:::|:|.:::|::....||:.::..|..||.||..|:..::|.||.:...:|....|...|
 Worm   268 VMSAVEEKIRAKLRERMGTNSAEMASIRTTSDELREGQQKLKRMLEELETQRSSLQTACEIYTAK 332

  Fly   316 EQELEKALEDLESAEAINPDEAVTTTAPLYRQLLNAYADEAATEDAIYYLGEGLRGGVIDLETFL 380
            :.||.|||.|....:|...|||:....||:||::..||.:...:|.||.||:.|:...|.|..:|
 Worm   333 KAELAKALSDAGGTDAPPIDEAIDAAFPLHRQIVLNYAKDLTCDDVIYSLGQSLKKRQITLAEYL 397

  Fly   381 KHVRQLSRKQFILRATMQKCRQKAGL 406
            :|||.:||:|||.||||||||:.|||
 Worm   398 RHVRDVSREQFIYRATMQKCRRTAGL 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_524120.1	UEV	22..140	CDD:283415	52/117 (44%)
		ARS2	<149..227	CDD:282772	33/88 (38%)
		TBPIP	<242..353	CDD:284512	37/110 (34%)
		Vps23_core	336..393	CDD:286532	24/56 (43%)
tsg-101	NP_500364.2	UEV	21..139	CDD:283415	52/117 (44%)
		Vps23_core	353..408	CDD:286532	22/54 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159955
Domainoid	1	1.000	118	1.000	Domainoid score	I3684
eggNOG	1	0.900	-	-		E1_KOG2391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4584
Inparanoid	1	1.050	284	1.000	Inparanoid score	I1729
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54978
OrthoDB	1	1.010	-	-		D1435538at2759
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		oto19563
orthoMCL	1	0.900	-	-		OOG6_102944
Panther	1	1.100	-	-	LDO	PTHR23306
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5678
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800