DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TSG101 and tsg101b

DIOPT Version :9

Sequence 1:	NP_524120.1	Gene:	TSG101 / 39881	FlyBaseID:	FBgn0036666	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_002662924.1	Gene:	tsg101b / 100333057	ZFINID:	ZDB-GENE-130530-542	Length:	393	Species:	Danio rerio

Alignment Length:	417	Identity:	197/417 - (47%)
Similarity:	263/417 - (63%)	Gaps:	37/417 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAVEETQITKYLSK-YKYVAATKKDVVDVVTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVY 64
            |.|:.|:.:.|..|| |||...|.:|:.:|...::.|...:..:||||||:|||.::.||:||.|
Zfish     1 MSAINESSLRKVFSKYYKYRDLTARDITNVTNIYKDLKPMMDNYVFNDGSTKELLSLTGTVPVNY 65

  Fly    65 KNNTYYIPICIWLMDTHPQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLI 129
            :.|.|.||:|:||:||:|.|.|:||||||..|.||...:||.||||||||||:|:|..|||..||
Zfish    66 RGNIYNIPVCLWLLDTYPYNPPICFVKPTSAMMIKPGKHVDANGKVYLPYLHEWKPPQSDLYGLI 130

  Fly   130 QVMIVTFGDHPPVYSKPKEQIAAPY------PTNSYMPQPGAPGGSNSFLPYPTAGGAGGSNFPP 188
            |||||.||:.|||:|:|..|.|.|.      |..||||.|..       |||.....|....|..
Zfish   131 QVMIVVFGEEPPVFSRPSSQPAYPAFPAAGPPNTSYMPTPQG-------LPYSQGHSANPGVFQG 188

  Fly   189 YPTGSNVGPYPPTPAGPAGGSGYPAYPNFIQPTAGG--YPPAAGYNPSNPSSTGTITEEHIKASI 251
            |       |||.|      |||||.       |:|.  |.|.:......||..|||.|:.|:||:
Zfish   189 Y-------PYPAT------GSGYPT-------TSGSSMYTPMSSVPTVGPSRDGTIGEDTIRASL 233

  Fly   252 ISAIDDKLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLEREHIDMQKNISILKDKE 316
            :||:.||||||::|:::..|||::.|.||:::|..|..|::.::.:|:.|..::.:||..||.|:
Zfish   234 VSAVSDKLRRRMKEEMDGAQAELDALRRTEEDLKRGHQKLEEMVTKLDVEMAEVDRNIDRLKQKD 298

  Fly   317 QELEKALEDLES-AEAINPDEAVTTTAPLYRQLLNAYADEAATEDAIYYLGEGLRGGVIDLETFL 380
            :||..|||.:|: ||..:.|:.:..|||||:|:||.||:|.|.||.|:||||.||..||||:.||
Zfish   299 EELTAALERMENQAEDNDIDDVIVPTAPLYKQILNLYAEENAIEDTIFYLGEALRRDVIDLDVFL 363

  Fly   381 KHVRQLSRKQFILRATMQKCRQKAGLA 407
            ||||.||||||.|||.|||.|:.|||:
Zfish   364 KHVRLLSRKQFQLRALMQKARKIAGLS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_524120.1	UEV	22..140	CDD:283415	65/117 (56%)
		ARS2	<149..227	CDD:282772	27/85 (32%)
		TBPIP	<242..353	CDD:284512	47/111 (42%)
		Vps23_core	336..393	CDD:286532	37/56 (66%)
tsg101b	XP_002662924.1	Vps23_core	319..374	CDD:286532	35/54 (65%)
		UEV	23..141	CDD:283415	65/117 (56%)
		DUF1640	<239..295	CDD:285090	20/55 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581931
Domainoid	1	1.000	156	1.000	Domainoid score	I4150
eggNOG	1	0.900	-	-		E1_KOG2391
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2162
OMA	1	1.010	-	-		QHG54978
OrthoDB	1	1.010	-	-		D1435538at2759
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		otm24588
orthoMCL	1	0.900	-	-		OOG6_102944
Panther	1	1.100	-	-	O	PTHR23306
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770