DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nudC and Nudc

DIOPT Version :9

Sequence 1:	NP_001246805.1	Gene:	nudC / 39879	FlyBaseID:	FBgn0021768	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_035078.1	Gene:	Nudc / 18221	MGIID:	106014	Length:	332	Species:	Mus musculus

Alignment Length:	343	Identity:	179/343 - (52%)
Similarity:	237/343 - (69%)	Gaps:	30/343 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEGKFDNILLAVAEKHHGGVPEFLGTLASFLRRKTDFFTGAKQTEWEKLLLDVFNKESKLAVTEN 68
            ||.:||.:|||:|::|.|||.|.:.|..||||||||||.|.::...|||:...||..::||....
Mouse     6 EEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFNHHNQLAQKAR 70

  Fly    69 YEKIKAREASQRLKAEKERAERKAR-----KQEIDDNKICDITDEEAAAIIKEEETKK-----RQ 123
            .|| :||:.::|    :|:|||.||     |.|....:|.::|||||..:..|.:.||     ..
Mouse    71 REK-RARQETER----REKAERAARLAKEAKAETPGPQIKELTDEEAERLQLEIDQKKDAEDQEA 130

  Fly   124 QL----LDSAGGEPSASNRDGISKPIEKVDDESDKSELGKLMPNAGNGCTLENYTWTQTLEEVEL 184
            ||    |||.|.:.:           |..:||.|:.:.|||.||.|||..|.||.|||||.|::|
Mouse   131 QLKNGSLDSPGKQDA-----------EDEEDEEDEKDKGKLKPNLGNGADLPNYRWTQTLAELDL 184

  Fly   185 KIPFNLTFGLRARDLVISIGKKSLKVGIKGQTPIIDGELCGEVKTEESVWVLQDSKTVMITLDKI 249
            .:||.::|.|:.:|:|:.|.::.|:||:|||.|::||||..|||.|||.|:::|.|.|.:.|:||
Mouse   185 AVPFRVSFRLKGKDVVVDIQRRHLRVGLKGQPPVVDGELYNEVKVEESSWLIEDGKVVTVHLEKI 249

  Fly   250 NKMNWWSRLVTTDPEISTRKINPESSKLSDLDGETRSMVEKMMYDQRQKELGLPTSEDRKKQDIL 314
            |||.||:||||:||||:|:|||||:|||||||.||||||||||||||||.:|||||:::|||:||
Mouse   250 NKMEWWNRLVTSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEIL 314

  Fly   315 EKFKQQHPEMDFSKCKFN 332
            :||..|||||||||.|||
Mouse   315 KKFMDQHPEMDFSKAKFN 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nudC	NP_001246805.1	Nudc_N	7..58	CDD:290757	26/50 (52%)
nudC	NP_001246805.1	p23_mNUDC_like	173..259	CDD:107241	45/85 (53%)
Nudc	NP_035078.1	Nudc_N	9..60	CDD:290757	26/50 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..108		16/47 (34%)
		Nuclear localization signal. /evidence=ECO:0000255	68..74		2/6 (33%)
		NuDC	98..>144	CDD:292890	16/45 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..171		19/58 (33%)
		p23_mNUDC_like	173..259	CDD:107241	45/85 (53%)
		Interaction with EML4. /evidence=ECO:0000250\|UniProtKB:Q9Y266	174..332		102/157 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840048
Domainoid	1	1.000	148	1.000	Domainoid score	I4458
eggNOG	1	0.900	-	-		E1_KOG2265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4812
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2320
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56463
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003931
OrthoInspector	1	1.000	-	-		oto93884
orthoMCL	1	0.900	-	-		OOG6_102007
Panther	1	1.100	-	-	LDO	PTHR12356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R854
SonicParanoid	1	1.000	-	-		X2707
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790