DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9674 and GLT1

DIOPT Version :9

Sequence 1:	NP_001246804.1	Gene:	CG9674 / 39878	FlyBaseID:	FBgn0036663	Length:	2115	Species:	Drosophila melanogaster
Sequence 2:	NP_010110.1	Gene:	GLT1 / 851383	SGDID:	S000002330	Length:	2145	Species:	Saccharomyces cerevisiae

Alignment Length:	2163	Identity:	1081/2163 - (49%)
Similarity:	1437/2163 - (66%)	Gaps:	116/2163 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SDNFD---SSAIGGSGDNFEESNELHLNGQQDQDVQEEQQQQMPWE--APGKQGLYDPQNEHEAC 88
            |||||   .:..||:..|:.:.:.||.:                |.  .|.|:|||||..||:||
Yeast     6 SDNFDPLEEAYEGGTIQNYNDEHHLHKS----------------WANVIPDKRGLYDPDYEHDAC 54

  Fly    89 GVGFIVAIDGKRSHKILRDAQTLSERMNHRGACACDNDTGDGAGVLASIPHGLYSKALAKQ-GVT 152
            ||||:....|::||||:.||:.|...|.||||.:.|.: |||||:|..|||....:..... .:.
Yeast    55 GVGFVANKHGEQSHKIVTDARYLLVNMTHRGAVSSDGN-GDGAGILLGIPHEFMKREFKLDLDLD 118

  Fly   153 LPELGDYATG-IFYLDEAQH-----AAAEKEFDDLAKSLGLEVIAWRTVPSNQSAIGVVARKSEP 211
            :||:|.||.| :|:....::     ...:|.|:|||.|..|.|:.||.||.:.:.:|.||...||
Yeast   119 IPEMGKYAVGNVFFKKNEKNNKKNLIKCQKIFEDLAASFNLSVLGWRNVPVDSTILGDVALSREP 183

  Fly   212 LSRQVFV------RRPAGSDEKAFERQVFVLRKRASHELIKPGRR--FYICSLSDRTVVYKGLFT 268
            ...|..:      ::|..::.| |..|:::|||.||.::   |..  ||:|||::.|:||||..|
Yeast   184 TILQPLLVPLYDEKQPEFNETK-FRTQLYLLRKEASLQI---GLENWFYVCSLNNTTIVYKGQLT 244

  Fly   269 SDQLWDYYTDLKDPEFETYLALVHTRFSTNTFPSWERAHPLRVLAHNGEINTLRGNVNLMKAREG 333
            ..|:::||.||.:..|::::||||:||||||||||:||.|||.|||||||||||||.|.|::|||
Yeast   245 PAQVYNYYPDLTNAHFKSHMALVHSRFSTNTFPSWDRAQPLRWLAHNGEINTLRGNKNWMRSREG 309

  Fly   334 VMQSDLFGDQLKKLYPVVEPNLSDSGSFDCVLEFLTMASDRSLPESVMTMVPEAWQNDKTMPQEK 398
            ||.|..|.|:|.||||::|...|||.:.|.|||.||:....||||:||.|||||:..|  |..:.
Yeast   310 VMNSATFKDELDKLYPIIEEGGSDSAALDNVLELLTINGTLSLPEAVMMMVPEAYHKD--MDSDL 372

  Fly   399 RDFYQWAACVMEPWDGPALISFTDGRYIGAVLDRNGLRPSRFYVTKENVLVMASEVGVYDVDPSQ 463
            :.:|.||||:|||||||||::||||||.||:||||||||.|:|:|.::.::.||||||..::.|.
Yeast   373 KAWYDWAACLMEPWDGPALLTFTDGRYCGAILDRNGLRPCRYYITSDDRVICASEVGVIPIENSL 437

  Fly   464 VTLKSRLKPGRMLLVDTKEKKLIQDIELKAKIAKSRPHSEWLQQKMITLDEI--RNANVLNTPPV 526
            |..|.:||||.:.||||:..:::...:||::|:|.:....|| .|:|.||::  :.||::   |.
Yeast   438 VVQKGKLKPGDLFLVDTQLGEMVDTKKLKSQISKRQDFKSWL-SKVIKLDDLLSKTANLV---PK 498

  Fly   527 DELAKLPASERGIFDPRLSLFGYSTETVNMLLIPMFKNKKEALGSMGNDAPLACLSNFQPIPYEY 591
            :.:::...|.:...||||...||:.|.|..||.||....||||||||||||||||:....:.|:|
Yeast   499 EFISQDSLSLKVQSDPRLLANGYTFEQVTFLLTPMALTGKEALGSMGNDAPLACLNENPVLLYDY 563

  Fly   592 FKQLFAQVTNPPIDPFREKVVMSMQCPLGPEANLLQPSAQQVHRIWLTNPILSIPDTQLLK--RN 654
            |:|||||||||||||.||..|||::|.:||:.|||:..:.|..|:.|.:|||...:.|.||  ..
Yeast   564 FRQLFAQVTNPPIDPIREANVMSLECYVGPQGNLLEMHSSQCDRLLLKSPILHWNEFQALKNIEA 628

  Fly   655 THRGWRTKVLDITFQYNEGVQGYIDAIDRICREGYAAAQAGYQLLVISDRGAGIDGKVAVSALLA 719
            .:..|....:||||..:||:.||.|.||:|.:....|...|.::|:|:||..|.: :|::|:|:|
Yeast   629 AYPSWSVAEIDITFDKSEGLLGYTDTIDKITKLASEAIDDGKKILIITDRKMGAN-RVSISSLIA 692

  Fly   720 LGALHHHLIETLQRMKVGIVVETAEAREVHHICVLLGYGADAICPYLAFELAQALRDDGVIAPEV 784
            :..:|||||...||.:|.:::||.||||:||.|||||||.|.:.||||.|....:..:|::....
Yeast   693 ISCIHHHLIRNKQRSQVALILETGEAREIHHFCVLLGYGCDGVYPYLAMETLVRMNREGLLRNVN 757

  Fly   785 NDK------QIYAAYAQAIDTGIAKVMAKMGISTLQSYKSAQIFEAVGLGSDLVAKCFRGTQSRI 843
            ||.      ||...|..|||.||.|||:|||||||.|||.||||||:||.:.:|..||.||.|||
Yeast   758 NDNDTLEEGQILENYKHAIDAGILKVMSKMGISTLASYKGAQIFEALGLDNSIVDLCFTGTSSRI 822

  Fly   844 GGVTLEILAKEGLQRYQLTYGKATPDTRILRNP--GQYHWRHGGEAHINEPSSIGSLQEAAVNKN 906
            .|||.|.||::....::..|......::.:..|  |:||:|.||..|:|||::|.|||:...|||
Yeast   823 RGVTFEYLAQDAFSLHERGYPSRQTISKSVNLPESGEYHFRDGGYKHVNEPTAIASLQDTVRNKN 887

  Fly   907 LDAFEAFKKTTLDSVKKCALRGQLEFVTDRQ-SIDISEVEPASEIVKRFATGAMSFGSISLEAHQ 970
            ..:::.:.|..:::::.|.|||.||...:.. ||.:.:|||.:||.:|||:||||:||||:|||.
Yeast   888 DVSWQLYVKKEMEAIRDCTLRGLLELDFENSVSIPLEQVEPWTEIARRFASGAMSYGSISMEAHS 952

  Fly   971 TLSITMNRIGGKSNTGEGGEDSDRYLNQDPNNSRRSAIKQVASGRFGVTASYLANADDLQIKMAQ 1035
            ||:|.|||:|.|||.||||||::|...|:..::.|||||||||.|||||:.||::||::|||:||
Yeast   953 TLAIAMNRLGAKSNCGEGGEDAERSAVQENGDTMRSAIKQVASARFGVTSYYLSDADEIQIKIAQ 1017

  Fly  1036 GAKPGEGGELPGYKVTKDIAKTRKSVPGVGLISPPPHHDIYSIEDLAELIYDLKCSNPNARISVK 1100
            |||||||||||.:||:|||||||.|.|.||||||||||||||||||.:|||||||:||.|.||||
Yeast  1018 GAKPGEGGELPAHKVSKDIAKTRHSTPNVGLISPPPHHDIYSIEDLKQLIYDLKCANPRAGISVK 1082

  Fly  1101 LVSEVGVGVVASGVAKGKAEHIVISGHDGGTGASSWTGIKNAGLPWELGVAETHQVLVLNNLRSR 1165
            ||||||||:|||||||.||:||::|||||||||:.||.:|.||||||||:|||||.||||:||..
Yeast  1083 LVSEVGVGIVASGVAKAKADHILVSGHDGGTGAARWTSVKYAGLPWELGLAETHQTLVLNDLRRN 1147

  Fly  1166 VIVQADGQLRTGFDVVVAALLGADEFGFSTAPLIVMGCTMMRKCHLNTCPVGIATQDPELRKKFT 1230
            |:||.|||||||||:.||.||||:.|..:|.|||.|||.|:|:||||:|.||||||||.||.||.
Yeast  1148 VVVQTDGQLRTGFDIAVAVLLGAESFTLATVPLIAMGCVMLRRCHLNSCAVGIATQDPYLRSKFK 1212

  Fly  1231 GKPEHVINFFFMLAEDIRKIMAGLGIRKFQDLIGRTDLLRVASQRDAKASNLDLKLLLQPALELR 1295
            |:||||||||:.|.:|:|:|||.||.|...:::|.::.|:.....:|||.|:||..:|.||..:|
Yeast  1213 GQPEHVINFFYYLIQDLRQIMAKLGFRTIDEMVGHSEKLKKRDDVNAKAINIDLSPILTPAHVIR 1277

  Fly  1296 PG--TNIVGGSVKQDFQLEKRSDNELIAKAQ-QIFSGADDNVTVKMRIHNEERAFGSTLSYHIAC 1357
            ||  |..   :.|||.:|..|.||:||.:|: .:..|...|:...  |.|.:||.||||||.::.
Yeast  1278 PGVPTKF---TKKQDHKLHTRLDNKLIDEAEVTLDRGLPVNIDAS--IINTDRALGSTLSYRVSK 1337

  Fly  1358 KYGEAGLPAGKSIDIFLEGSAGQSFCAFLARGVNVTLKGDANDYVGKGLCGGNVVIMPQDTVPFE 1422
            |:||.|||. .::.:.:||||||||.||||.|:...|.|||||||||||.||.:||.|.....|:
Yeast  1338 KFGEDGLPK-DTVVVNIEGSAGQSFGAFLASGITFILNGDANDYVGKGLSGGIIVIKPPKDSKFK 1401

  Fly  1423 SHLNVIVGNVCLYGATEGTAYFRGIASERFCVRNSGVTAVVEGV-GDHGCEYMTGGVVVILG-LT 1485
            |..||||||.|.||||.|||:..|.|.|||.|||||.|.|||.: |::..||||||..::|. :.
Yeast  1402 SDENVIVGNTCFYGATSGTAFISGSAGERFGVRNSGATIVVERIKGNNAFEYMTGGRAIVLSQME 1466

  Fly  1486 GRNFAAGMSGGIAYVYDLD-GSFKPKVNPESVELLPLEIEKDVLLVKELLADFIEKTGSKVAKEL 1549
            ..|..:|.:|||||....| ..|..|:|.::|||..|....::..||.|:.:....|.|.:|..:
Yeast  1467 SLNAFSGATGGIAYCLTSDYDDFVGKINKDTVELESLCDPVEIAFVKNLIQEHWNYTQSDLAARI 1531

  Fly  1550 LDNWAEAQGKFVKVFPYEYQKA-LKDMAE---------------------------------QQA 1580
            |.|:......||||.|.:|:|. ||:.||                                 |:|
Yeast  1532 LGNFNHYLKDFVKVIPTDYKKVLLKEKAEAAKAKAKATSEYLKKFRSNQEVDDEVNTLLIANQKA 1596

  Fly  1581 VEQPLKSAIENGNGK--HEPHIKDIEEAIQDVVLEQKRADRVLDKTRGFVKYKRESAPYRDAGER 1643
            .||..|.:|...|..  .||.:.|:|:|:.|....:|.::|: :|||||:.:||....:||...|
Yeast  1597 KEQEKKKSITISNKATLKEPKVVDLEDAVPDSKQLEKNSERI-EKTRGFMIHKRRHETHRDPRTR 1660

  Fly  1644 QKDWDEVYNFPHVRKNLKVQAARCMECGVPFCQSNSTGCPLGNIIPKWNDLVFHGEWQEALRQLL 1708
            ..||.|..| |..:|:.|.|.||||:||.|||.|: |||||.|||||:|:|:|..:|:.||.:||
Yeast  1661 VNDWKEFTN-PITKKDAKYQTARCMDCGTPFCLSD-TGCPLSNIIPKFNELLFKNQWKLALDKLL 1723

  Fly  1709 QTNNFPEFTGRVCPAPCEGSCVLGISEPAVTIKNIECAIIDHAFEQGWIKPEIPEVRTGKRVAIV 1773
            :||||||||||||||||||:|.|||.|..|.||::|..|||:||::|||||..|..|||..|.::
Yeast  1724 ETNNFPEFTGRVCPAPCEGACTLGIIEDPVGIKSVERIIIDNAFKEGWIKPCPPSTRTGFTVGVI 1788

  Fly  1774 GSGPSGLAASQQLNRAGHFVTVFERNDRVGGLLQYGIPTMKLSKEVVKRRVDLMADEGIEFRTNV 1838
            ||||:|||.:..||||||.|||:||:||.||||.||||.|||.|.:|:||:||::.|||:|.||.
Yeast  1789 GSGPAGLACADMLNRAGHTVTVYERSDRCGGLLMYGIPNMKLDKAIVQRRIDLLSAEGIDFVTNT 1853

  Fly  1839 HVGKDLKAEQLLQEYDAVLLTTGSTWPRDLPLANRDLKGIHFAMEFLEAQQKKQLGGKNDII--S 1901
            .:||.:..::|..:::||:...|||.|||||:..|:||.|.|||:.||:..|..|....:||  .
Yeast  1854 EIGKTISMDELKNKHNAVVYAIGSTIPRDLPIKGRELKNIDFAMQLLESNTKALLNKDLEIIREK 1918

  Fly  1902 AAGKNVIIIGGGDTGCDCIATSLRQGAKSITTFEILPEPPQKRAQDNPWPQWPKVFRVDYGHEEV 1966
            ..||.||::||||||.||:.||:|.||.|:..||:|||||.:||:||||||||:|.||||||.||
Yeast  1919 IQGKKVIVVGGGDTGNDCLGTSVRHGAASVLNFELLPEPPVERAKDNPWPQWPRVMRVDYGHAEV 1983

  Fly  1967 KLKWGKDPRQYCTTTKEFVG-ENGAIKGVNTVEVEWTKTETGQWRMQEVAGSEKYFPADLILLAM 2030
            |..:|:|||:||..:|||:| :.|.:..:.||.|||.|:::|.|:|.|:..||:.|.||:|||:|
Yeast  1984 KEHYGRDPREYCILSKEFIGNDEGEVTAIRTVRVEWKKSQSGVWQMVEIPNSEEIFEADIILLSM 2048

  Fly  2031 GFLGPEKTVPSELGLELDPRGNIKA-SNGQYGTSNSKVFAAGDCRRGQSLVVWAITEGRQAARQV 2094
            ||:|||....::..::...||.|.. .:..|.....|.||.|||||||||:||||.|||:.|..|
Yeast  2049 GFVGPELINGNDNEVKKTRRGTIATLDDSSYSIDGGKTFACGDCRRGQSLIVWAIQEGRKCAASV 2113

  Fly  2095 DSYLTGRPSGLPGPGGVI 2112
            |.:|....:.||..||::
Yeast  2114 DKFLMDGTTYLPSNGGIV 2131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9674	NP_001246804.1	gltB	75..1565	CDD:236968	779/1523 (51%)
		GATase_2	88..504	CDD:278726	204/430 (47%)
		Glu_syn_central	543..828	CDD:282720	146/292 (50%)
		GltS_FMN	918..1271	CDD:239202	237/353 (67%)
		gltB_C	1316..1565	CDD:238482	118/252 (47%)
		gltD	1623..2106	CDD:237213	264/486 (54%)
		Fer4_8	1645..1756	CDD:302761	68/110 (62%)
		NAD_binding_8	1772..>1804	CDD:290186	20/31 (65%)
GLT1	NP_010110.1	gltB	41..1547	CDD:236968	779/1523 (51%)
GLT1	NP_010110.1	GOGAT_sm_gam	1640..2125	CDD:162300	264/486 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346125
Domainoid	1	1.000	510	1.000	Domainoid score	I45
eggNOG	1	0.900	-	-		E1_COG0069
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5537
Inparanoid	1	1.050	1978	1.000	Inparanoid score	I3
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57723
OrthoFinder	1	1.000	-	-		FOG0006699
OrthoInspector	1	1.000	-	-		oto100274
orthoMCL	1	0.900	-	-		OOG6_100905
Panther	1	1.100	-	-	LDO	PTHR11938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16330
SonicParanoid	1	1.000	-	-		X4899
TreeFam	1	0.960	-	-
	15	14.790