DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9674 and GLU2

DIOPT Version :9

Sequence 1:	NP_001246804.1	Gene:	CG9674 / 39878	FlyBaseID:	FBgn0036663	Length:	2115	Species:	Drosophila melanogaster
Sequence 2:	NP_181655.1	Gene:	GLU2 / 818721	AraportID:	AT2G41220	Length:	1629	Species:	Arabidopsis thaliana

Alignment Length:	1591	Identity:	671/1591 - (42%)
Similarity:	943/1591 - (59%)	Gaps:	120/1591 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LYDPQNEHEACGVGFIVAIDGKRSHKILRDAQTLSERMNHRGACACDNDTGDGAGVLASIPHGLY 142
            |.|..:|..|||||||..::.|.:|||:.||......|.|||.|..||.:|||:|::.|||..|:
plant    98 LEDIISERGACGVGFIANLENKATHKIVNDALIALGCMEHRGGCGSDNTSGDGSGLMTSIPWDLF 162

  Fly   143 SKALAKQGVTLPELGDYATGIFYL--DEAQHAAAEKEFDDLAKSLGLEVIAWRTVPSNQSAIGVV 205
            ::...|||:...:......|:.:|  |:.....|:|....:.:..||||:.||.||...|.:|..
plant   163 NEWAEKQGIASFDRTHTGVGMLFLPRDDNIRKEAKKVITSIFEKEGLEVLGWRDVPVEASIVGHN 227

  Fly   206 ARKSEPLSRQVFVRRPAGSDEKA--FERQVFVLRKRASHELIKP--GRRFYICSLSDRTVVYKGL 266
            |:::.|.:.|||||  ...|:|.  .||::::.||.....:...  ....|..|||::|:||||:
plant   228 AKQTMPNTEQVFVR--IVKDDKVDDVERELYICRKLIERAVASESWASELYFSSLSNQTIVYKGM 290

  Fly   267 FTSDQLWDYYTDLKDPEFETYLALVHTRFSTNTFPSWERAHPLRVLAHNGEINTLRGNVNLMKAR 331
            ..|:.|..:|.||::..:::..|:.|.||||||.|.|..|.|:|.|.|||||||::||:|.|.:|
plant   291 LRSEVLGLFYPDLQNDLYKSPFAIYHRRFSTNTSPRWHLAQPMRFLGHNGEINTIQGNLNWMTSR 355

  Fly   332 EGVMQSDLFGDQLKKLYPVVEPNLSDSGSFDCVLEFLTMASDRSLPESVMTMVPEAWQNDKTMP- 395
            |..::|.::..:...:.|:..|..|||.:.|...|.| :.|.|:..||:|.:||||::|..|:.
plant   356 EASLRSPVWHGRENDIRPISNPKASDSANLDSAAELL-IRSGRTPEESLMILVPEAYKNHPTLMI 419

  Fly   396 --QEKRDFYQWAACVMEPWDGPALISFTDGRYIGAVLDRNGLRPSRFYVTKENVLVMASEVGVYD 458
              .|..|||.:....|||||||||:.|:||:.:||.||||||||:|::.|.:||:.:||||||..
plant   420 KYPEAVDFYDYYKGQMEPWDGPALVLFSDGKTVGACLDRNGLRPARYWRTSDNVVYVASEVGVLP 484

  Fly   459 VDPSQVTLKSRLKPGRMLLVDTKEKKLIQDIELKAKIAKSRPHSEWLQQKMITLDEIRNANVLNT 523
            :|.|:||:|.||.||.|:.||.:..::.::.|:|.::|...|:.:|:.:   .|..::.:|.|::
plant   485 MDESKVTMKGRLGPGMMISVDLENGQVYENTEVKKRVASYNPYGKWVSE---NLRNLKPSNYLSS 546

  Fly   524 P--PVDELAKLPASERGIFDPRLSLFGYSTETVNMLLIPMFKNKKEALGSMGNDAPLACLSNFQP 586
            .  ..||..:           |...||||:|.|.|::..|....||....||:|.|:|.||....
plant   547 AILETDETLR-----------RQQAFGYSSEDVQMVIESMAAQGKEPTFCMGDDTPVAVLSQKPH 600

  Fly   587 IPYEYFKQLFAQVTNPPIDPFREKVVMSMQCPLGPEANLLQPSAQQVHRIWLTNPILSIPDTQ-- 649
            :.|:||||.|||||||.|||.||.:|||::..:|...|:|:...|.|.::.|:.|:|:..:.:
plant   601 MLYDYFKQRFAQVTNPAIDPLREGLVMSLEVNIGKRGNILEVGPQNVSQVVLSGPVLNERELEGL 665

  Fly   650 ----LLKRNTHRGWRTKVLDITFQYNEGVQGYI-DAIDRICREGYAAAQAGYQLLVISDRGAGID 709
                |||        :::|...|....|::|.: ..:.::|.....|.:.|.|:||:|||....:
plant   666 LGDPLLK--------SQILPTFFDIRRGIEGSLKKGLLKLCEAADEAVRNGSQVLVLSDRSDNPE 722

  Fly   710 -GKVAVSALLALGALHHHLIETLQRMKVGIVVETAEAREVHHICVLLGYGADAICPYLAFELAQA 773
             .:.|:..|||:||:|.|||:...||...|:.:||:....||...|:||||.||||:||.|..:.
plant   723 PTRPAIPMLLAVGAVHQHLIQNGLRMSASIIADTAQCFSTHHFACLIGYGASAICPHLALETCRQ 787

  Fly   774 LR---------DDGVIAPEVNDKQIYAAYAQAIDTGIAKVMAKMGISTLQSYKSAQIFEAVGLGS 829
            .|         .:|.: |.|..:|....|.:|::||:.||::|||||...||..|||||..|||:
plant   788 WRLSNKTVNMMRNGKM-PTVTMEQAQKNYRKAVNTGLLKVLSKMGISLFSSYCGAQIFEIYGLGN 851

  Fly   830 DLVAKCFRGTQSRIGGVTLEILAKEGLQRYQLTYGKATPDTRILRNPGQYHWRHGGEAHINEPSS 894
            ::|...|||:.|:|||:||:.||:|.|..:...:.:.|  .:.|.|.|...:|.|||.|.|.|..
plant   852 EVVEFSFRGSASQIGGLTLDELARETLTFWVRAFSEDT--AKRLENFGFIQFRPGGEYHGNNPEM 914

  Fly   895 IGSLQEAAVNKNLDAFEAFKKTTLDSVKKCALRGQLEFVTDRQSIDISEVEPASEIVKRFATGAM 959
            ...|.:|...|:..|:..::: .|.:......|..|||.:||..|.:.:|||||.||:||.||.|
plant   915 SKLLHKAVREKSETAYAVYQQ-HLANRPITVFRDLLEFKSDRNPIPVGKVEPASSIVERFCTGGM 978

  Fly   960 SFGSISLEAHQTLSITMNRIGGKSNTGEGGEDS----------DRYLNQDPN-------NSRRSA 1007
            |.|:||.|.|:|::|.|||:|||||:||||||.          |.|.:..|:       ::..||
plant   979 SLGAISRETHETIAIAMNRLGGKSNSGEGGEDPIRWKPLTDVVDGYSSTLPHLKGLRNGDTATSA 1043

  Fly  1008 IKQVASGRFGVTASYLANADDLQIKMAQGAKPGEGGELPGYKVTKDIAKTRKSVPGVGLISPPPH 1072
            ||||||||||||.::|.|||.|:||:||||||||||:|||.||:..||:.|.|.|||.|||||||
plant  1044 IKQVASGRFGVTPTFLVNADQLEIKVAQGAKPGEGGQLPGKKVSAYIARLRNSKPGVPLISPPPH 1108

  Fly  1073 HDIYSIEDLAELIYDLKCSNPNARISVKLVSEVGVGVVASGVAKGKAEHIVISGHDGGTGASSWT 1137
            ||||||||||:||:||...||.|::|||||||.|:|.|||||||..|:.|.|||:|||||||..:
plant  1109 HDIYSIEDLAQLIFDLHQVNPKAKVSVKLVSETGIGTVASGVAKANADIIQISGYDGGTGASPIS 1173

  Fly  1138 GIKNAGLPWELGVAETHQVLVLNNLRSRVIVQADGQLRTGFDVVVAALLGADEFGFSTAPLIVMG 1202
            .||:||.|||||:|||.:.|:.|.||.|||::.||..::|.||::||.:||||:||.|..:|..|
plant  1174 SIKHAGGPWELGLAETQKTLIGNGLRERVIIRVDGGFKSGVDVLIAAAMGADEYGFGTLAMIATG 1238

  Fly  1203 CTMMRKCHLNTCPVGIATQDPELRKKFTGKPEHVINFFFMLAEDIRKIMAGLGIRKFQDLIGRTD 1267
            |.|.|.||.|.||||:|:|..|||.:|.|.|..::|||..:||::|.|:|.||..|..|:|||||
plant  1239 CIMARICHTNNCPVGVASQREELRARFPGLPGDLVNFFLYIAEEVRGILAQLGYEKLDDIIGRTD 1303

  Fly  1268 LLRVASQRDAK--ASNLDLKLLLQP-ALELRPGTNIVGGSVKQDFQLEKRSDNELIAKAQQIFSG 1329
            ||:.   ||..  .::|||..||.. .|..|..|:|    .||:........::.:.:..:|...
plant  1304 LLKA---RDISLVKTHLDLSYLLSSVGLPKRSSTSI----RKQEVHSNGPVLDDTLLQDPEIMDA 1361

  Fly  1330 ADDNVTV--KMRIHNEERAFGSTLSYHIACKYGEAGLPAGKSIDIFLEGSAGQSFCAFLARGVNV 1392
            .::..||  .|.|:|.:|:....::..||.|||:.|. ||: :::...|||||||..||..|:|:
plant  1362 IENEKTVHKTMSIYNVDRSVCGRIAGVIAKKYGDTGF-AGQ-LNLTFTGSAGQSFACFLTPGMNI 1424

  Fly  1393 TLKGDANDYVGKGLCGGNVVIMPQDTVPFESHLNVIVGNVCLYGATEGTAYFRGIASERFCVRNS 1457
            .|.|:||||||||:.||.|||:|.::..|......||||.||||||.|..:.||.|.|||.||||
plant  1425 RLVGEANDYVGKGMAGGEVVILPVESTGFRPEDATIVGNTCLYGATGGLLFVRGKAGERFAVRNS 1489

  Fly  1458 GVTAVVEGVGDHGCEYMTGGVVVILGLTGRNFAAGMSGGIAYVYDLDGSFKPKVNPESVELLPLE 1522
            ...|||||.|||.|||||||.|||||..|||.||||:||:||:.|.|.:..||:|.|.|::..:.
plant  1490 LAQAVVEGTGDHCCEYMTGGCVVILGKVGRNVAAGMTGGLAYILDEDNTLLPKMNKEIVKIQRVT 1554

  Fly  1523 IEKDVLLVKELLADFIEKTGSKVAKELLDNWAEAQGKFVKVFPYEYQKALKDMAEQQAVEQPLKS 1587
            .......:|.|:...:|||||.....:::.|.:....|.::.|
plant  1555 SPVGQTQLKSLIQAHVEKTGSSKGAMIVEEWDKYLAMFWQLVP---------------------- 1597

  Fly  1588 AIENGNGKHEPHIKDIEEAIQDVVLEQKRAD 1618
                      |..:|..||..|.:|:....|
plant  1598 ----------PSEEDTPEANSDHILKTTTGD 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9674	NP_001246804.1	gltB	75..1565	CDD:236968	663/1536 (43%)
		GATase_2	88..504	CDD:278726	171/424 (40%)
		Glu_syn_central	543..828	CDD:282720	115/301 (38%)
		GltS_FMN	918..1271	CDD:239202	212/369 (57%)
		gltB_C	1316..1565	CDD:238482	111/250 (44%)
		gltD	1623..2106	CDD:237213
		Fer4_8	1645..1756	CDD:302761
		NAD_binding_8	1772..>1804	CDD:290186
GLU2	NP_181655.1	gltB	104..1598	CDD:236968	662/1563 (42%)
		GATase_2	108..530	CDD:278726	171/424 (40%)
		Glu_syn_central	556..850	CDD:282720	115/313 (37%)
		GltS_FMN	911..1306	CDD:239202	216/395 (55%)
		gltB_C	1348..1598	CDD:238482	112/283 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0069
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126283at2759
OrthoFinder	1	1.000	-	-		FOG0006699
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100905
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4899
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.680