DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9674 and glt1

DIOPT Version :9

Sequence 1:	NP_001246804.1	Gene:	CG9674 / 39878	FlyBaseID:	FBgn0036663	Length:	2115	Species:	Drosophila melanogaster
Sequence 2:	NP_594133.1	Gene:	glt1 / 2543509	PomBaseID:	SPAPB1E7.07	Length:	2111	Species:	Schizosaccharomyces pombe

Alignment Length:	2086	Identity:	1124/2086 - (53%)
Similarity:	1448/2086 - (69%)	Gaps:	80/2086 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PGKQGLYDPQNEHEACGVGFIVAIDGKRSHKILRDAQTLSERMNHRGACACDNDTGDGAGVLASI 137
            |..|.||||..|.::|||||...|.|:.||||:.||:.|...|.||||...|...||||||:..:
pombe    54 PKAQALYDPAYEKDSCGVGFTCHIKGQVSHKIVTDARLLLCNMTHRGATGADTRDGDGAGVMTGM 118

  Fly   138 PHGLYSKALAKQGVTLPELGDYATG-IFYLDEAQHA-AAEKEFDDLAKSLGLEVIAWRTVPSNQS 200
            |:....|...:.|.|||:.|:||.| :|:..||... .|...|..:|:.|||.::|||:||.:.|
pombe   119 PYTFMQKEFGQIGCTLPKSGEYAIGNVFFSPEADVCREAMTAFTQVAEKLGLAILAWRSVPCDNS 183

  Fly   201 AIGVVARKSEPLSRQVFVRRPAGSDEKA------FERQVFVLRKRASHELIKPGRRFYICSLSDR 259
            .:|..|...||...|..|...|..|.:|      ||||::||||::|| ||...:.||||||...
pombe   184 ILGPAALSREPTILQPCVVLKAAYDGEAEFDTDLFERQLYVLRKQSSH-LIGKEKWFYICSLHRE 247

  Fly   260 TVVYKGLFTSDQLWDYYTDLKDPEFETYLALVHTRFSTNTFPSWERAHPLRVLAHNGEINTLRGN 324
            |:||||.....|:::|:.||.:.|:.::.||||:||||||||||:||.|:|:.||||||||||||
pombe   248 TIVYKGQLAPVQVYNYFLDLNNAEYVSHFALVHSRFSTNTFPSWDRAQPMRLAAHNGEINTLRGN 312

  Fly   325 VNLMKAREGVMQSDLFGDQLKKLYPVVEPNLSDSGSFDCVLEFLTMASDRSLPESVMTMVPEAWQ 389
            .|.|.||||:|:|..||::...|.|::|...|||.:||.|:|.|..:...||||:||.::|||||
pombe   313 KNWMHAREGLMKSSRFGEEFASLLPIIERGGSDSAAFDNVIELLCASGVVSLPEAVMLLIPEAWQ 377

  Fly   390 NDKTMPQEKRDFYQWAACVMEPWDGPALISFTDGRYIGAVLDRNGLRPSRFYVTKENVLVMASEV 454
            |||.:..||..||:||||.|||||||||.:|.||||.||.||||||||.|||:|.:::::.||||
pombe   378 NDKNISDEKAAFYEWAACQMEPWDGPALFTFADGRYCGANLDRNGLRPCRFYLTSDDMMICASEV 442

  Fly   455 GVYDVDPSQVTLKSRLKPGRMLLVDTKEKKLIQDIELKAKIAKSRPHSEWLQQKMITLDE----- 514
            |...::|.::..|.||.|||||||||||.:::.|.|||..||.......||.|::|.::.
pombe   443 GTVGIEPDRIVQKGRLYPGRMLLVDTKEGRIVDDKELKHNIASRYDFRSWLDQELIDMNSIVDSL 507

  Fly   515 IRNANVLNTPPVDELAKLPASERGIFDPRLSLFGYSTETVNMLLIPMFKNKKEALGSMGNDAPLA 579
            |.:.:|..||.||:   :|.::    |..:..|||:.|.:||::.||....||.||||||||.:|
pombe   508 IESTSVDLTPIVDD---VPLAD----DKTMLAFGYTLEQINMIMAPMANGGKETLGSMGNDAAIA 565

  Fly   580 CLSNFQPIPYEYFKQLFAQVTNPPIDPFREKVVMSMQCPLGPEANLLQPSAQQVHRIWLTNPILS 644
            |||:...:.|:||:|||||||||||||.||.:|||:||.:||..|||:.:..|..|:.:..|||:
pombe   566 CLSDQPRLLYDYFRQLFAQVTNPPIDPIREAIVMSLQCYIGPSGNLLEINQSQCRRLRMPTPILT 630

  Fly   645 IPDTQLLKRNTHR---GWRTKVLDITFQYNEGVQGYIDAIDRICREGYAAAQAGYQLLVISDRGA 706
            :.:...|| |..|   .|:...:||||..:|||.||..||:|||.|...|...||:.:|:|||..
pombe   631 VEEFNALK-NVDRIYPDWKVASIDITFFKSEGVAGYAAAIERICSEADTAVNEGYKAIVLSDRNV 694

  Fly   707 GIDGKVAVSALLALGALHHHLIETLQRMKVGIVVETAEAREVHHICVLLGYGADAICPYLAFELA 771
            ..: :|.::::.|.||:||:|::...|.:|.:|.|:.:||||||:|.||||||||:|||||.|..
pombe   695 NSE-RVPLASIAACGAVHHYLVQNKLRSRVALVCESGDAREVHHMCTLLGYGADAVCPYLAMEAL 758

  Fly   772 QALRDDGVIAPEVNDKQIYAAYAQAIDTGIAKVMAKMGISTLQSYKSAQIFEAVGLGSDLVAKCF 836
            ..|.....:.|.:.::.....:..||:.||.|||:|||||||||||.||||||:|:.::::.|||
pombe   759 TKLVRQNAMKPGITEETAIKNFKHAINGGILKVMSKMGISTLQSYKGAQIFEALGIDNEVINKCF 823

  Fly   837 RGTQSRIGGVTLEILAKEGLQRYQLTYGKATPDTRILRNP--GQYHWRHGGEAHINEPSSIGSLQ 899
            .||.|||.|||.|.:|.:....::..| ......|.|:.|  |.:::|.|||.|:|.|.:|.|||
pombe   824 LGTASRIRGVTFEHIALDAFALHERGY-PTDQSIRSLQIPDMGDFYYRDGGEQHVNHPKAIASLQ 887

  Fly   900 EAAVNKNLDAFEAFKKTTLDSVKKCALRGQLEFVTD-RQSIDISEVEPASEIVKRFATGAMSFGS 963
            :|..|||..|:..|.:|..:..::|.|||.|:|..| .|:|.|.:|||.:|||:||.|||||:||
pombe   888 DAVRNKNEAAYAEFSRTHYEQTRRCTLRGMLDFDFDSSQAIPIEQVEPWTEIVRRFCTGAMSYGS 952

  Fly   964 ISLEAHQTLSITMNRIGGKSNTGEGGED---SDRYLNQDPNNSRRSAIKQVASGRFGVTASYLAN 1025
            ||:|:|.:|:|.|||:||||||||||||   |.|..|.|   :.||||||:||||||||:.||::
pombe   953 ISMESHSSLAIAMNRLGGKSNTGEGGEDPARSQRLANGD---TMRSAIKQIASGRFGVTSWYLSD 1014

  Fly  1026 ADDLQIKMAQGAKPGEGGELPGYKVTKDIAKTRKSVPGVGLISPPPHHDIYSIEDLAELIYDLKC 1090
            ||:|||||||||||||||||||.||::.|||||.|..|||||||||||||||||||.:||||:|.
pombe  1015 ADELQIKMAQGAKPGEGGELPGNKVSESIAKTRHSTAGVGLISPPPHHDIYSIEDLKQLIYDMKS 1079

  Fly  1091 SNPNARISVKLVSEVGVGVVASGVAKGKAEHIVISGHDGGTGASSWTGIKNAGLPWELGVAETHQ 1155
            :||.||:|||||||||||:|||||||.||:||::||||||||||.|||||.||||||||||||||
pombe  1080 ANPRARVSVKLVSEVGVGIVASGVAKAKADHILVSGHDGGTGASRWTGIKYAGLPWELGVAETHQ 1144

  Fly  1156 VLVLNNLRSRVIVQADGQLRTGFDVVVAALLGADEFGFSTAPLIVMGCTMMRKCHLNTCPVGIAT 1220
            .||||:||.||::|.|||:|||.||.:|.||||:|:||:|.|||.:||.||||||||||||||||
pombe  1145 TLVLNDLRGRVVIQTDGQIRTGRDVAIACLLGAEEWGFATTPLIALGCIMMRKCHLNTCPVGIAT 1209

  Fly  1221 QDPELRKKFTGKPEHVINFFFMLAEDIRKIMAGLGIRKFQDLIGRTDLLRVASQRDAKASNLDLK 1285
            |||||||||.|:||||:|||:.:||::|.|||.||.|...:::||:|.|:||...:.|:..|||.
pombe  1210 QDPELRKKFEGQPEHVVNFFYYVAEELRGIMAKLGFRTINEMVGRSDKLKVAEPINNKSKLLDLT 1274

  Fly  1286 LLLQPALELRPGT---NIVGGSVKQDFQLEKRSDNELIAKAQQIFSGADDNVTVKMRIHNEERAF 1347
            .||.||..||||.   |:    .|||.:|..|.||:||.:|:........:| |:..|.|.:|..
pombe  1275 PLLTPAFTLRPGAATYNV----RKQDHRLYTRLDNKLIDEAEVTLEEGIPSV-VECEIINTDRTL 1334

  Fly  1348 GSTLSYHIACKYGEAGLPAGKSIDIFLEGSAGQSFCAFLARGVNVTLKGDANDYVGKGLCGGNVV 1412
            |:|||..|:.:|||.|||. .||.:.:.|||||||.||||.||.:.|:||.||||||||.||.::
pombe  1335 GATLSNKISKRYGEEGLPT-DSIRVNVFGSAGQSFGAFLAPGVTLQLEGDCNDYVGKGLSGGRLI 1398

  Fly  1413 IMPQDTVPFESHLNVIVGNVCLYGATEGTAYFRGIASERFCVRNSGVTAVVEGVGDHGCEYMTGG 1477
            |.|....||:...|:|:|||||||||.|.|:..|:|:|||.|||||..|||||||||||||||||
pombe  1399 IYPPRVSPFKPEENMIIGNVCLYGATSGHAFISGVAAERFAVRNSGAIAVVEGVGDHGCEYMTGG 1463

  Fly  1478 VVVILGLTGRNFAAGMSGGIAYVYDLDGSFKPKVNPESVELLPLEIEKDVLLVKELLADFIEKTG 1542
            .|||||.||||||||||||||||||:...|..|:|.|.|::..:....::..::.|:.|....||
pombe  1464 RVVILGSTGRNFAAGMSGGIAYVYDMQMDFAGKINTEMVDISSVTDAAEIAFLRGLIQDHRHYTG 1528

  Fly  1543 SKVAKELLDNWAEAQGKFVKVFPYEYQKAL-KDMAEQQAVEQ-----------PLKSAIENGNGK 1595
            |:||..:|.::.....:||||.|.||:..| ::.|:::..::           |::..||..|.:
pombe  1529 SQVADRILSDFPRHLSRFVKVLPREYKAVLEREAAKKEEAKRLQYPKAFMPGNPIRQQIEETNAQ 1593

  Fly  1596 HEPHIKDIEEAIQDVVLEQKRADRVLDKTRGFVKYKRESAPYRDAGERQKDWDEVYNFPHVR--- 1657
                |.|:|:.:...|  :|.|.  |||.|||:||:|.|..||:..:|..||.|:    .||
pombe  1594 ----IADVEDTLGATV--KKSAP--LDKLRGFMKYQRRSEHYRNPLKRTNDWKEL----SVRLRE 1646

  Fly  1658 KNLKVQAARCMECGVPFCQSNSTGCPLGNIIPKWNDLVFHGEWQEALRQLLQTNNFPEFTGRVCP 1722
            ..|:||.||||:||.|||||: .|||:.|.|..||||||..:|:|||.|||.|||||||||||||
pombe  1647 DELRVQTARCMDCGTPFCQSD-YGCPISNKIFTWNDLVFKQQWKEALTQLLLTNNFPEFTGRVCP 1710

  Fly  1723 APCEGSCVLGISEPAVTIKNIECAIIDHAFEQGWIKPEIPEVRTGKRVAIVGSGPSGLAASQQLN 1787
            |||||:|.|||.|..|.||::|.||||.|:|:|||.|..|..|||:||||:||||:||||:.|||
pombe  1711 APCEGACTLGIIESPVGIKSVERAIIDKAWEEGWIVPRPPAERTGRRVAIIGSGPAGLAAADQLN 1775

  Fly  1788 RAGHFVTVFERNDRVGGLLQYGIPTMKLSKEVVKRRVDLMADEGIEFRTNVHVGK--DLKAEQLL 1850
            ||||.|.::||.||.|||||||||.|||.|:||:||:.||.|||||..|||.|||  |:..::|.
pombe  1776 RAGHHVVIYERADRPGGLLQYGIPNMKLDKKVVERRIQLMIDEGIEVLTNVEVGKNGDVSLDELH 1840

  Fly  1851 QEYDAVLLTTGSTWPRDLPLANRDLKGIHFAMEFLEAQQKKQLGGK---NDIISAAGKNVIIIGG 1912
            :.||||:|.:|||.|||||:.|||.||||||||||....|..|..:   .:.|||.||:||:|||
pombe  1841 KVYDAVVLASGSTVPRDLPIPNRDSKGIHFAMEFLHKNTKSLLDSELKDGNYISAKGKDVIVIGG 1905

  Fly  1913 GDTGCDCIATSLRQGAKSITTFEILPEPPQKRAQDNPWPQWPKVFRVDYGHEEVKLKWGKDPRQY 1977
            ||||.||:.||:|.||||:...|:||.||::||.||||||:|:||||||||.||:..:|:|.|:|
pombe  1906 GDTGNDCLGTSVRHGAKSVRNLELLPIPPRERAFDNPWPQYPRVFRVDYGHAEVQAHYGQDFREY 1970

  Fly  1978 CTTTKEF-VGENGAIKGVNTVEVEWTKTETGQWRMQEVAGSEKYFPADLILLAMGFLGPEKTVPS 2041
            ...||.| ..|:|.:||:|||.:||||...|:|.|:|:..||::|||||::||:||||||:...:
pombe  1971 SILTKSFEKDEDGNVKGINTVRIEWTKNSKGRWIMKEIRNSEEFFPADLVILALGFLGPEEQATA 2035

  Fly  2042 ELGLELDPRGNIKASNGQYGTSNSKVFAAGDCRRGQSLVVWAITEGRQAARQVDSYLTGRPSGLP 2106
            .:.::.|.|.||......|.||...::||||||||||||||.|.||||.||::|....|: :.||
pombe  2036 GMNVDRDARSNISTPTKSYETSVPGIYAAGDCRRGQSLVVWGIQEGRQCAREIDLKFQGK-TFLP 2099

  Fly  2107 GPGGVI 2112
            |.||::
pombe  2100 GDGGLV 2105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9674	NP_001246804.1	gltB	75..1565	CDD:236968	814/1514 (54%)
		GATase_2	88..504	CDD:278726	215/423 (51%)
		Glu_syn_central	543..828	CDD:282720	141/287 (49%)
		GltS_FMN	918..1271	CDD:239202	251/356 (71%)
		gltB_C	1316..1565	CDD:238482	133/248 (54%)
		gltD	1623..2106	CDD:237213	287/491 (58%)
		Fer4_8	1645..1756	CDD:302761	70/113 (62%)
		NAD_binding_8	1772..>1804	CDD:290186	21/31 (68%)
glt1	NP_594133.1	gltB	56..1567	CDD:236968	819/1530 (54%)
		GATase_2	69..492	CDD:278726	215/423 (51%)
		Glu_syn_central	528..815	CDD:282720	141/288 (49%)
		GltS_FMN	880..1260	CDD:239202	263/382 (69%)
		gltB_C	1303..1552	CDD:238482	133/250 (53%)
		GOGAT_sm_gam	1613..2099	CDD:162300	287/491 (58%)
		Fer4_8	1635..1744	CDD:302761	70/113 (62%)
		NAD_binding_8	1760..>1804	CDD:290186	32/43 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	527	1.000	Domainoid score	I45
eggNOG	1	0.900	-	-		E1_COG0069
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5537
Inparanoid	1	1.050	2025	1.000	Inparanoid score	I2
OMA	1	1.010	-	-		QHG57723
OrthoFinder	1	1.000	-	-		FOG0006699
OrthoInspector	1	1.000	-	-		oto102037
orthoMCL	1	0.900	-	-		OOG6_100905
Panther	1	1.100	-	-	LDO	PTHR11938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16330
SonicParanoid	1	1.000	-	-		X4899
TreeFam	1	0.960	-	-
	14	13.860