DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9674 and AgaP_AGAP006360

DIOPT Version :9

Sequence 1:	NP_001246804.1	Gene:	CG9674 / 39878	FlyBaseID:	FBgn0036663	Length:	2115	Species:	Drosophila melanogaster
Sequence 2:	XP_316385.4	Gene:	AgaP_AGAP006360 / 1276969	VectorBaseID:	AGAP006360	Length:	2076	Species:	Anopheles gambiae

Alignment Length:	2121	Identity:	1575/2121 - (74%)
Similarity:	1803/2121 - (85%)	Gaps:	59/2121 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPTITDNCEFECATVEATTTSAITIGDSDNFDSSAIGGSGDNFEESNELHLNGQQDQDVQEEQQ 65
            |||. .:.|.:|.....||.|..:                             .||.....:..:
Mosquito     1 MAPP-NNECSYEVINNVATATEEL-----------------------------AQQRSTENDASK 35

  Fly    66 QQMPWEAPGKQGLYDPQNEHEACGVGFIVAIDGKRSHKILRDAQTLSERMNHRGACACDNDTGDG 130
            .||.||.||.|||||||||||||||||||:|:||.:||||||||||:.|||||||||||||||||
Mosquito    36 TQMDWETPGAQGLYDPQNEHEACGVGFIVSIEGKPNHKILRDAQTLAIRMNHRGACACDNDTGDG 100

  Fly   131 AGVLASIPHGLYSKALAKQGVTLPELGDYATGIFYLDEAQHAAAEKEFDDLAKSLGLEVIAWRTV 195
            |||..||||.||:|.||..|:.||..|.|||||||||::.|..|||||:.||:|||::|:.||:|
Mosquito   101 AGVCTSIPHDLYAKELASHGIDLPAFGRYATGIFYLDKSSHEEAEKEFNALAESLGVQVLYWRSV 165

  Fly   196 PSNQSAIGVVARKSEPLSRQVFVRRPAGSDEKAFERQVFVLRKRASHELIKPGRRFYICSLSDRT 260
            |:||.|:|.||||||||||||||  .|..||:.|:||||:|||||:|||.:||||||||||:.:|
Mosquito   166 PTNQEAVGAVARKSEPLSRQVFV--TADVDEETFKRQVFILRKRATHELQRPGRRFYICSLTPKT 228

  Fly   261 VVYKGLFTSDQLWDYYTDLKDPEFETYLALVHTRFSTNTFPSWERAHPLRVLAHNGEINTLRGNV 325
            :||||||||||||:||.|||:|:|.||||||||||||||||||||||||||||||||||||||||
Mosquito   229 IVYKGLFTSDQLWEYYLDLKNPDFLTYLALVHTRFSTNTFPSWERAHPLRVLAHNGEINTLRGNV 293

  Fly   326 NLMKAREGVMQSDLFGDQLKKLYPVVEPNLSDSGSFDCVLEFLTMASDRSLPESVMTMVPEAWQN 390
            ||||||||||:|:.|||:|||||||||||||||||.||||||||...:|||||:|||||||||||
Mosquito   294 NLMKAREGVMKSEQFGDELKKLYPVVEPNLSDSGSCDCVLEFLTAVGNRSLPEAVMTMVPEAWQN 358

  Fly   391 DKTMPQEKRDFYQWAACVMEPWDGPALISFTDGRYIGAVLDRNGLRPSRFYVTKENVLVMASEVG 455
            |:||.|||||||.|:|||||||||||||||||||||||:||||||||||||||::|:|:||||
Mosquito   359 DRTMSQEKRDFYHWSACVMEPWDGPALISFTDGRYIGAILDRNGLRPSRFYVTRDNLLIMASE-- 421

  Fly   456 VYDVDPSQVTLKSRLKPGRMLLVDTKEKKLIQDIELKAKIAKSRPHSEWLQQKMITLDEIRNANV 520
                        |||||||||||||::|.||||||||::|||||||||||::: ||:|:||....
Mosquito   422 ------------SRLKPGRMLLVDTEQKSLIQDIELKSEIAKSRPHSEWLKEQ-ITMDDIRREAG 473

  Fly   521 LNTPPVDELAKLP-----ASERGIFDPRLSLFGYSTETVNMLLIPMFKNKKEALGSMGNDAPLAC 580
            ..|....|||...     |.::||.||||.|:||:|||::|||:||.||||||||||||||||||
Mosquito   474 AITNGSTELAVTNGDTQLAEKKGILDPRLQLYGYTTETIHMLLLPMIKNKKEALGSMGNDAPLAC 538

  Fly   581 LSNFQPIPYEYFKQLFAQVTNPPIDPFREKVVMSMQCPLGPEANLLQPSAQQVHRIWLTNPILSI 645
            ||.|||:|||||||||||||||||||||||::||:|||:|||||||..|..|||||||.||||||
Mosquito   539 LSAFQPLPYEYFKQLFAQVTNPPIDPFREKIIMSLQCPIGPEANLLVASPSQVHRIWLDNPILSI 603

  Fly   646 PDTQLLKRNTHRGWRTKVLDITFQYNEGVQGYIDAIDRICREGYAAAQAGYQLLVISDRGAGIDG 710
            ||.::||||.||||:||||||||..|||..|||..:.|:|.|..||||.||||||:|||.|..:
Mosquito   604 PDAEVLKRNQHRGWKTKVLDITFPANEGPPGYIGGLRRVCAEAQAAAQGGYQLLVLSDRSASAE- 667

  Fly   711 KVAVSALLALGALHHHLIETLQRMKVGIVVETAEAREVHHICVLLGYGADAICPYLAFELAQALR 775
            :..:|:||||||:|||||||.||||||::|||||||||||||||||||||||||||.||:|.|||
Mosquito   668 RAPISSLLALGAVHHHLIETRQRMKVGLIVETAEAREVHHICVLLGYGADAICPYLVFEMAGALR 732

  Fly   776 DDGVIAPEVNDKQIYAAYAQAIDTGIAKVMAKMGISTLQSYKSAQIFEAVGLGSDLVAKCFRGTQ 840
            |:.|:.|.:.|..||.|||.|::|||.|||||||||||||||.||||||||:|:|::..||||||
Mosquito   733 DECVLDPALTDDAIYRAYATAVETGILKVMAKMGISTLQSYKGAQIFEAVGMGADVIDLCFRGTQ 797

  Fly   841 SRIGGVTLEILAKEGLQRYQLTYGKATPDTRILRNPGQYHWRHGGEAHINEPSSIGSLQEAAVNK 905
            |||||||||:||:|||:|::|.:|....|.:|||||||:|||.|||.|||||.:|.:|||||||:
Mosquito   798 SRIGGVTLEVLAREGLERHELVHGTNHADAKILRNPGQFHWRAGGEGHINEPGAIAALQEAAVNE 862

  Fly   906 NLDAFEAFKKTTLDSVKKCALRGQLEFVTDRQSIDISEVEPASEIVKRFATGAMSFGSISLEAHQ 970
            :..|:..|:.||:.||:.|.||||||||..|..:::||||||||||||||||||||||||||||.
Mosquito   863 SKGAYATFRDTTMRSVQLCTLRGQLEFVKGRPRVELSEVEPASEIVKRFATGAMSFGSISLEAHS 927

  Fly   971 TLSITMNRIGGKSNTGEGGEDSDRYLNQDPNNSRRSAIKQVASGRFGVTASYLANADDLQIKMAQ 1035
            ||:|:|||||||||||||||::|||:||||.::|||||||||||||||||:|:||||||||||||
Mosquito   928 TLAISMNRIGGKSNTGEGGENADRYMNQDPQHNRRSAIKQVASGRFGVTAAYVANADDLQIKMAQ 992

  Fly  1036 GAKPGEGGELPGYKVTKDIAKTRKSVPGVGLISPPPHHDIYSIEDLAELIYDLKCSNPNARISVK 1100
            |||||||||||||||::|||.||.|||||||||||||||||||||||||||||||:||.||||||
Mosquito   993 GAKPGEGGELPGYKVSQDIADTRHSVPGVGLISPPPHHDIYSIEDLAELIYDLKCANPKARISVK 1057

  Fly  1101 LVSEVGVGVVASGVAKGKAEHIVISGHDGGTGASSWTGIKNAGLPWELGVAETHQVLVLNNLRSR 1165
            ||||||||||||||||||||||||||||||||||||||||:||||||||:||||||||||:||||
Mosquito  1058 LVSEVGVGVVASGVAKGKAEHIVISGHDGGTGASSWTGIKSAGLPWELGIAETHQVLVLNDLRSR 1122

  Fly  1166 VIVQADGQLRTGFDVVVAALLGADEFGFSTAPLIVMGCTMMRKCHLNTCPVGIATQDPELRKKFT 1230
            |:||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.||.
Mosquito  1123 VVVQADGQLRTGFDVVVAALLGADEFGFSTAPLIVMGCTMMRKCHLNTCPVGIATQDPVLRAKFA 1187

  Fly  1231 GKPEHVINFFFMLAEDIRKIMAGLGIRKFQDLIGRTDLLRVASQRDAKASNLDLKLLLQPALELR 1295
            ||||||||:||||||:||:|||.||:|:||:||||:|||:|..:...|||.|||::||:.||:||
Mosquito  1188 GKPEHVINYFFMLAEEIREIMAELGLRRFQELIGRSDLLKVREKASYKASLLDLQMLLKSALDLR 1252

  Fly  1296 PGTNIVGGSVKQDFQLEKRSDNELIAKAQQIFSGADDNVTVKMRIHNEERAFGSTLSYHIACKYG 1360
            |||||||||::|||.||||:|||||.::..:..|::.:.|:.|||:||||||.|||||.||.:||
Mosquito  1253 PGTNIVGGSLRQDFVLEKRADNELIKQSMGVIEGSEQHKTIAMRINNEERAFSSTLSYEIARRYG 1317

  Fly  1361 EAGLPAGKSIDIFLEGSAGQSFCAFLARGVNVTLKGDANDYVGKGLCGGNVVIMPQDTVPFESHL 1425
            :||||.|::|::.|.|||||||.|||.:||.:||.|||||||||.|.||.:||.|.:...|||||
Mosquito  1318 DAGLPNGRTINVNLTGSAGQSFGAFLVKGVKMTLHGDANDYVGKSLSGGTIVIRPPEGTTFESHL 1382

  Fly  1426 NVIVGNVCLYGATEGTAYFRGIASERFCVRNSGVTAVVEGVGDHGCEYMTGGVVVILGLTGRNFA 1490
            |||||||||||||.|.|:|||||:||||||||||||||||||||||||||||:||||||||||||
Mosquito  1383 NVIVGNVCLYGATSGRAFFRGIAAERFCVRNSGVTAVVEGVGDHGCEYMTGGMVVILGLTGRNFA 1447

  Fly  1491 AGMSGGIAYVYDLDGSFKPKVNPESVELLPLEIEKDVLLVKELLADFIEKTGSKVAKELLDNWAE 1555
            ||||||||||.|:||:|:.||||..||||.||:::|...||:||.:|:.:|||:||||||..|.|
Mosquito  1448 AGMSGGIAYVLDVDGTFRSKVNPGMVELLGLELDEDRQTVKDLLQEFVNETGSEVAKELLSKWPE 1512

  Fly  1556 AQGKFVKVFPYEYQKALKDMAEQQAVEQPLKSAIENGNGKHEPHIKDIEEAIQDVVLEQKRADRV 1620
            ...:|||||||||||||..:.|:...    |:...||:.| ||.:|||||:|||..|.:|:.|:|
Mosquito  1513 PCQQFVKVFPYEYQKALAALKEKTVA----KAITANGHPK-EPQVKDIEESIQDGQLAKKKLDQV 1572

  Fly  1621 LDKTRGFVKYKRESAPYRDAGERQKDWDEVYNFPHVRKNLKVQAARCMECGVPFCQSNSTGCPLG 1685
            |||||||:|||||::.||:|.:||:||.||:||||||.|||||||||||||||||||||.|||||
Mosquito  1573 LDKTRGFIKYKRETSVYRNAADRQQDWKEVFNFPHVRSNLKVQAARCMECGVPFCQSNSHGCPLG 1637

  Fly  1686 NIIPKWNDLVFHGEWQEALRQLLQTNNFPEFTGRVCPAPCEGSCVLGISEPAVTIKNIECAIIDH 1750
            |||||||||||:|.|:||:.||||||||||||||||||||||:||||||||||||||||||||||
Mosquito  1638 NIIPKWNDLVFNGNWREAINQLLQTNNFPEFTGRVCPAPCEGACVLGISEPAVTIKNIECAIIDH 1702

  Fly  1751 AFEQGWIKPEIPEVRTGKRVAIVGSGPSGLAASQQLNRAGHFVTVFERNDRVGGLLQYGIPTMKL 1815
            |||||||.|::|.||||||||:|||||:||||:||||:|||.|||||||||.|||||||||||||
Mosquito  1703 AFEQGWITPQVPRVRTGKRVAVVGSGPAGLAAAQQLNKAGHLVTVFERNDRPGGLLQYGIPTMKL 1767

  Fly  1816 SKEVVKRRVDLMADEGIEFRTNVHVGKDLKAEQLLQEYDAVLLTTGSTWPRDLPLANRDLKGIHF 1880
            |||||:||:|||..||||||.|||:|:|:...||.|||||||.|||:||||||.|.|||||||||
Mosquito  1768 SKEVVQRRLDLMVAEGIEFRCNVHIGRDVMGSQLEQEYDAVLFTTGATWPRDLNLPNRDLKGIHF 1832

  Fly  1881 AMEFLEAQQKKQLGGKNDIISAAGKNVIIIGGGDTGCDCIATSLRQGAKSITTFEILPEPPQKRA 1945
            |||||:|.|:|..|.:.|.|||.||:||:|||||||||||||||||||||||||||||.|.:|||
Mosquito  1833 AMEFLQASQQKLNGSRPDWISAEGKDVIVIGGGDTGCDCIATSLRQGAKSITTFEILPIPSEKRA 1897

  Fly  1946 QDNPWPQWPKVFRVDYGHEEVKLKWGKDPRQYCTTTKEFVGE-NGAIKGVNTVEVEWTKTETGQW 2009
            |||||||||::||||||||||::|||||||||.|||||||.: ||:|||||||:||||||.||||
Mosquito  1898 QDNPWPQWPRIFRVDYGHEEVRVKWGKDPRQYSTTTKEFVSDGNGSIKGVNTVQVEWTKTPTGQW 1962

  Fly  2010 RMQEVAGSEKYFPADLILLAMGFLGPEKTVPSELGLELDPRGNIKASNGQYGTSNSKVFAAGDCR 2074
            .|:||.|||||:||||||||||||||||..|:|:.||||.|||||.:.|.|||:|.|||||||||
Mosquito  1963 SMKEVPGSEKYYPADLILLAMGFLGPEKQAPNEMNLELDGRGNIKTTVGMYGTANPKVFAAGDCR 2027

  Fly  2075 RGQSLVVWAITEGRQAARQVDSYLTGRPSGLPGPGGVIATS 2115
            ||||||||||:||||||||:|:||.|:||.||||||||.|:
Mosquito  2028 RGQSLVVWAISEGRQAARQIDTYLMGKPSALPGPGGVIDTT 2068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9674	NP_001246804.1	gltB	75..1565	CDD:236968	1129/1494 (76%)
		GATase_2	88..504	CDD:278726	321/415 (77%)
		Glu_syn_central	543..828	CDD:282720	215/284 (76%)
		GltS_FMN	918..1271	CDD:239202	308/352 (88%)
		gltB_C	1316..1565	CDD:238482	171/248 (69%)
		gltD	1623..2106	CDD:237213	391/483 (81%)
		Fer4_8	1645..1756	CDD:302761	99/110 (90%)
		NAD_binding_8	1772..>1804	CDD:290186	25/31 (81%)
AgaP_AGAP006360	XP_316385.4	gltB	45..1522	CDD:236968	1129/1494 (76%)
		GATase_2	58..458	CDD:278726	321/415 (77%)
		Glu_syn_central	501..783	CDD:282720	213/282 (76%)
		GltS_FMN	858..1228	CDD:239202	316/369 (86%)
		gltB_C	1273..1522	CDD:238482	171/248 (69%)
		gltD	1575..2059	CDD:237213	391/483 (81%)
		Fer4_8	1613..1708	CDD:302761	87/94 (93%)
		MDR	<1702..>1815	CDD:302572	89/112 (79%)
		NAD_binding_8	1724..>1756	CDD:290186	25/31 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	700	1.000	Domainoid score	I450
eggNOG	1	0.900	-	-		E1_COG0069
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5537
Inparanoid	1	1.050	3222	1.000	Inparanoid score	I61
OMA	1	1.010	-	-		QHG57723
OrthoDB	1	1.010	-	-		D126283at2759
OrthoFinder	1	1.000	-	-		FOG0006699
OrthoInspector	1	1.000	-	-		oto111100
Panther	1	1.100	-	-	LDO	PTHR11938
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4899
TreeFam	1	0.960	-	-
	13	12.940