DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3e and EIF3E

DIOPT Version :9

Sequence 1:	NP_477385.1	Gene:	eIF3e / 39877	FlyBaseID:	FBgn0025582	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	XP_016868887.2	Gene:	EIF3E / 3646	HGNCID:	3277	Length:	452	Species:	Homo sapiens

Alignment Length:	434	Identity:	260/434 - (59%)
Similarity:	331/434 - (76%)	Gaps:	8/434 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANFDLTRINCQFLDRHLTFPLLEFLCGKEIYNQQELLEYILETVNKTNMIDYTMDTRKRLNLSQ 65
            ||.:|||.....||||||.|||||||..|||||::|||:..|:.::.|||:|:.||..|.| .|.
Human     1 MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNL-YSD 64

  Fly    66 EMPEELVQRKAEVLATLKQLQNEVAPIMKA---TDILKNGESMKDSKTFVNALQKDYNFKVEHLE 127
            ::|..|.:::..|:|.|||||.|..||:|.   .:..:..:|.:|.:...:.|...:.|:.|:|:
Human    65 DIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLD 129

  Fly   128 SAYKLAKYLYECGNYQESTSYLYFCLIVMSPNDKNYLNVLWGKLAAEILTLNWNTALEDLTRLRD 192
            :.|:.||:.||||||..:..||||..:::...|:|.|:.||||||:|||..||:.|:||||||::
Human   130 TLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKE 194

  Fly   193 YIDNANFST-IQALQQRTWLIHWSVLVFFNHPKGRDLIIEMFLYKPLYLNAIQTMCPHIMRYLAT 256
            .|||.:.|: :|:|||||||||||:.||||||||||.||::|||:|.||||||||||||:|||.|
Human   195 TIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTT 259

  Fly   257 AVVIN---RTRRNALKDLIKVIQQESYTYRDPITEFLECLYVNFDFEGARLKLHECQTVILNDFF 318
            ||:.|   |.||..||||:||||||||||:||||||:|||||||||:||:.||.||::|::||||
Human   260 AVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFF 324

  Fly   319 IVACLNEFVEDARLMIFETFCRIHQCITISMLADKLNMKPNEAECWIVNLIRNARLNAKIDSKLG 383
            :||||.:|:|:|||.||||||||||||:|:||||||||.|.|||.|||||||||||:||||||||
Human   325 LVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLG 389

  Fly   384 HVVMGTQPLSPYQQLVEKIDSLSMRSEHLAGLIERKSKQKQNQE 427
            |||||...:|||||::||..|||.||:.||..||:|..|....|
Human   390 HVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSE 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3e	NP_477385.1	eIF3E	3..418	CDD:411062	254/421 (60%)
EIF3E	XP_016868887.2	eIF3_N	5..137	CDD:312814	55/132 (42%)
EIF3E	XP_016868887.2	PCI	290..394	CDD:307522	82/103 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143488
Domainoid	1	1.000	212	1.000	Domainoid score	I2790
eggNOG	1	0.900	-	-		E1_KOG2758
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1205
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1248
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55232
OrthoDB	1	1.010	-	-		D1151808at2759
OrthoFinder	1	1.000	-	-		FOG0003441
OrthoInspector	1	1.000	-	-		oto90999
orthoMCL	1	0.900	-	-		OOG6_102060
Panther	1	1.100	-	-	LDO	PTHR10317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R380
SonicParanoid	1	1.000	-	-		X2338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800