DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3e and eif3ea

DIOPT Version :9

Sequence 1:	NP_477385.1	Gene:	eIF3e / 39877	FlyBaseID:	FBgn0025582	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_957133.1	Gene:	eif3ea / 325102	ZFINID:	ZDB-GENE-030131-3827	Length:	446	Species:	Danio rerio

Alignment Length:	439	Identity:	261/439 - (59%)
Similarity:	328/439 - (74%)	Gaps:	8/439 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANFDLTRINCQFLDRHLTFPLLEFLCGKEIYNQQELLEYILETVNKTNMIDYTMDTRKRLNLSQ 65
            ||.:|||.....||||||.|||||||..|||||:.|||...|:.::.|||:|:.||..:.|...:
Zfish     1 MAEYDLTTKIAHFLDRHLVFPLLEFLSVKEIYNEHELLHGKLDLLSDTNMVDFAMDVYRNLFPDK 65

  Fly    66 EMPEELVQRKAEVLATLKQLQNEVAPIMKA---TDILKNGESMKDSKTFVNALQKDYNFKVEHLE 127
            |:|..|.:::..|:|.|||||:|..||:|.   .:..:..:|.:|.:...:.|...:.|:.|:|:
Zfish    66 EIPNSLREKRTTVVAQLKQLQSETEPIVKVFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLD 130

  Fly   128 SAYKLAKYLYECGNYQESTSYLYFCLIVMSPNDKNYLNVLWGKLAAEILTLNWNTALEDLTRLRD 192
            :.|:.||:.||||||..:..||||..:::...|:|.||.||||||:|||..||..|:|||||||:
Zfish   131 TLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALNSLWGKLASEILMQNWEAAMEDLTRLRE 195

  Fly   193 YIDNANFST-IQALQQRTWLIHWSVLVFFNHPKGRDLIIEMFLYKPLYLNAIQTMCPHIMRYLAT 256
            .|||...|: :|:|||||||||||:.||||||||||.|||:|||:|.||||||||||||:|||.|
Zfish   196 TIDNNTVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIELFLYQPQYLNAIQTMCPHILRYLTT 260

  Fly   257 AVVIN---RTRRNALKDLIKVIQQESYTYRDPITEFLECLYVNFDFEGARLKLHECQTVILNDFF 318
            ||:.|   |.||..||||:||||||||||:||||||:|||||||||:.|:.||.||:.|::||||
Zfish   261 AVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDSAQKKLRECEAVLVNDFF 325

  Fly   319 IVACLNEFVEDARLMIFETFCRIHQCITISMLADKLNMKPNEAECWIVNLIRNARLNAKIDSKLG 383
            :||||.:|:|:|||.||||||||||||:|.||||||||.|.|||.|||||||||||:||||||||
Zfish   326 LVACLEDFIENARLFIFETFCRIHQCISIGMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLG 390

  Fly   384 HVVMGTQPLSPYQQLVEKIDSLSMRSEHLAGLIERKSKQKQNQESADSW 432
            |||||...:|||||::||..|||.||:.||..||:| :...|:....:|
Zfish   391 HVVMGNNAISPYQQVIEKTKSLSFRSQMLAMNIEKK-QSNANRNETPNW 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3e	NP_477385.1	eIF3E	3..418	CDD:411062	255/421 (61%)
eif3ea	NP_957133.1	eIF3_N	5..138	CDD:286519	54/132 (41%)
		PCI	291..395	CDD:279707	81/103 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..446		3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576362
Domainoid	1	1.000	215	1.000	Domainoid score	I2660
eggNOG	1	0.900	-	-		E1_KOG2758
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1205
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1192
OMA	1	1.010	-	-		QHG55232
OrthoDB	1	1.010	-	-		D1151808at2759
OrthoFinder	1	1.000	-	-		FOG0003441
OrthoInspector	1	1.000	-	-		otm25021
orthoMCL	1	0.900	-	-		OOG6_102060
Panther	1	1.100	-	-	LDO	PTHR10317
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770