DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3e and int6

DIOPT Version :9

Sequence 1:	NP_477385.1	Gene:	eIF3e / 39877	FlyBaseID:	FBgn0025582	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_595367.1	Gene:	int6 / 2541089	PomBaseID:	SPBC646.09c	Length:	501	Species:	Schizosaccharomyces pombe

Alignment Length:	483	Identity:	154/483 - (31%)
Similarity:	249/483 - (51%)	Gaps:	86/483 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDLTRINCQFLDRHLTFPLLEFLCGKEIYNQQELLEYILETVNKTNMIDYTMDTRKRL---NLSQ 65
            :||::...|.|||||.|||||||..::.::.:|||:...:.:..|||.||..:....|   :..:
pombe    15 YDLSQKIMQHLDRHLIFPLLEFLSLRQTHDPKELLQAKYDLLKDTNMTDYVANLWTNLHGGHTDE 79

  Fly    66 EMPEELVQRKAEVLATLKQLQNEVAPIMKATDILKNGESM----KDSKTFVNALQKDYNFKVEHL 126
            :|.....:::..||..|.:|:.||..|:   .:|:|.:.:    :|....:..||:.||...|.:
pombe    80 DMANAFAEKRRSVLQELSELEEEVQGIL---GVLENPDLIAALRQDKGQNLQHLQEHYNITPERI 141

  Fly   127 ESAYKLAKYLYECGNYQESTSYLYFCLIVMSPNDKNYLNVLWGKLAAEILTLNWNTALEDLTRLR 191
            ...||.|::.|.||||..::..||. ....|.:.:...:..|||.|:||||::|:.|:|:|.:||
pombe   142 AVLYKFAQFQYNCGNYGGASDLLYH-FRAFSKDPELNASATWGKFASEILTVDWDGAMEELGKLR 205

  Fly   192 DYIDNANF--STIQALQQRTWLIHWSVLVFFNHPKGRDLIIEMFLYKPLYLNAIQTMCPHIMRYL 254
            :.:|:.:|  |.:| |:.||||:|||:...|||..|.|.:.::|.|.| |||.|||.||.::|||
pombe   206 EMVDSKSFKDSAVQ-LRNRTWLLHWSLFPLFNHANGCDTLCDLFFYTP-YLNTIQTSCPWLLRYL 268

  Fly   255 ATAVVINRTRRN------------ALKDLIKVIQQESYTYRDPITEFLECLYVNFDFEGARLKLH 307
            ..|||.|:...|            .::||:::|.||:|.|.||:|.|:..||...|||.|:..|.
pombe   269 TVAVVTNQNNANQKPRNPRQSYQRRMRDLVRIISQENYEYSDPVTSFISALYTEVDFEKAQHCLR 333

  Fly   308 ECQTVILNDFFIVACLNEFVEDARLMIFETFCRIHQCITISMLADKLNMKPNEAECWIVNLIRNA 372
            ||:.|:..|||:|:..:.|:|.||.::.|.:||||..|::.:||:||.|...:    ::.|:.|.
pombe   334 ECEEVLKTDFFLVSLCDHFLEGARKLLAEAYCRIHSVISVDVLANKLEMDSAQ----LIQLVENR 394

  Fly   373 R-----------------------------------------------------LNAKIDSKLGH 384
            .                                                     ..||:|.:  .
pombe   395 NNPSVAAASNVAADQSTEDESIESTSTNVVADDLITEAETATEAEEPEPEVQFGFKAKLDGE--S 457

  Fly   385 VVMGTQPLSPYQQLVEKIDSLSMRSEHL 412
            :::.....|.:||::::..|||..|::|
pombe   458 IIIEHPTYSAFQQIIDRTKSLSFESQNL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3e	NP_477385.1	eIF3E	3..418	CDD:411062	154/483 (32%)
int6	NP_595367.1	eIF3_N	16..150	CDD:286519	43/136 (32%)
int6	NP_595367.1	PCI	310..>391	CDD:295179	33/84 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I2768
eggNOG	1	0.900	-	-		E1_KOG2758
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1205
Inparanoid	1	1.050	261	1.000	Inparanoid score	I746
OMA	1	1.010	-	-		QHG55232
OrthoFinder	1	1.000	-	-		FOG0003441
OrthoInspector	1	1.000	-	-		oto101781
orthoMCL	1	0.900	-	-		OOG6_102060
Panther	1	1.100	-	-	LDO	PTHR10317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R380
SonicParanoid	1	1.000	-	-		X2338
TreeFam	1	0.960	-	-
	14	13.860