DRSC/TRiP Functional Genomics Resources

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Protein Alignment mus302 and RFWD3

DIOPT Version :10

Sequence 1:NP_648919.1 Gene:mus302 / 39874 FlyBaseID:FBgn0287696 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_060594.3 Gene:RFWD3 / 55159 HGNCID:25539 Length:774 Species:Homo sapiens


Alignment Length:630 Identity:171/630 - (27%)
Similarity:275/630 - (43%) Gaps:70/630 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LDPEVYADETSTD-DSSGDDEVILNPV-EGLQPAVEIDEQRDQPGENAEPEQPRVPPLILVDPPH 70
            ||.......|..| .::..|....||| |.||.:...|...|...|...          :||   
Human   178 LDAYFQVSRTQPDLPATTYDSETRNPVSEELQVSSSSDSDSDSSAEYGG----------VVD--- 229

  Fly    71 LPSPPRNSRRNQGEEQEVISLETPSPPKKRKRLSAAAD--KSLKKSP---EGKPIVVD---DEDD 127
                       |.||...:.||........::.....|  |:|.|.|   :.:|::..   ||::
Human   230 -----------QAEESGAVILEEQLAGVSAEQEVTCIDGGKTLPKQPSPQKSEPLLPSASMDEEE 283

  Fly   128 GMTCPICLDSWEMSGEHRLVSLRCGHLFGESCIRRWLNESHRQSSVKVCPQCKTKATFRDIRHLY 192
            |.||.|||:.|..:|:|||.:||||||||..||..||     :..|:.||||..||...||..||
Human   284 GDTCTICLEQWTNAGDHRLSALRCGHLFGYRCISTWL-----KGQVRKCPQCNKKARHSDIVVLY 343

  Fly   193 AKRIQMLDTDIREQLEAERRRTHTL----TTELATAKLANTLTTEKLILLQKDYERLKELV---- 249
            |:.::.|||..:|::::...:...|    ..|.|..:|...:.|:|...||:..:.|::|.    
Human   344 ARTLRALDTSEQERMKSSLLKEQMLRKQAELESAQCRLQLQVLTDKCTRLQRRVQDLQKLTSHQS 408

  Fly   250 -RAGGGRGAFGGDASGQKSIQQLATYRLYMEKNFEITRDPGCRVLLYSAKHSMLVASQKSAQNLF 313
             .....||:.....|...|.|....::.:.:|.|.:::...||::.|....|.||.||.|.|..|
Human   409 QNLQQPRGSQAWVLSCSPSSQGQHKHKYHFQKTFTVSQAGNCRIMAYCDALSCLVISQPSPQASF 473

  Fly   314 -PGYGVRFIDPPTFKPLQFLHTSALLIRDIAFSD-SQHLLTVASRELKIKIFDIRTRLCSSMFTA 376
             ||:||:.:.....|..|::......||.:|||. .:.||..||.:..||:..:.|......:.|
Human   474 LPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 538

  Fly   377 HDKMLWSCALDRNEREHFLYGGDLRGGVYIYDLRFPENILCEFQAEVNLSPVIHIA--PVQPNKI 439
             .:.:|||....:| .:::|.|...|.:.:||:|...:.:.|..|:....|::.::  |...:..
Human   539 -GRPVWSCCWCLDE-ANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAA 601

  Fly   440 FTSGGFLVCQLTALTFYEYAAASDTAVPTRLNVE-GPFLSMQYDAVQDTVLISARSNPNFPQSRF 503
            |..||.|...|...:|:| .....:..|..|.:| |..:..|.:......|::.|.:.|....|.
Human   602 FPYGGVLAGTLEDASFWE-QKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRS 665

  Fly   504 ILGRMD-KID--GTPVLKVKA--TIYGSKATPVMTR------PTQLAVEDNTLVVGYLQDSKQLM 557
            :|..|. ::|  |.|:...:.  |.:|.....::|:      |..   :.|.||....:.:...:
Human   666 VLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPEN---DGNILVCTGDEAANSAL 727

  Fly   558 MHDVRREERVQTMPVNEVIYDICPVATQAGSYLAALTDNKCRVYK 602
            :.|......:|.:..::.:.||||......||||.||:....:||
Human   728 LWDAASGSLLQDLQTDQPVLDICPFEVNRNSYLATLTEKMVHIYK 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mus302NP_648919.1 mRING-C3HGC3_RFWD3 127..192 CDD:438114 32/64 (50%)
WD40 <293..445 CDD:475233 44/155 (28%)
WD40 repeat 339..375 CDD:293791 12/36 (33%)
RFWD3NP_060594.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..225 14/46 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..280 5/22 (23%)
mRING-C3HGC3_RFWD3 283..343 CDD:438114 32/64 (50%)
WD 1 495..537 12/41 (29%)
WD40 496..762 CDD:475233 64/271 (24%)
WD40 repeat 500..537 CDD:293791 12/36 (33%)
WD 2 539..577 10/38 (26%)
WD40 repeat 543..580 CDD:293791 11/37 (30%)
WD 3 583..628 9/45 (20%)
WD40 repeat 588..655 CDD:293791 14/67 (21%)
Blue background indicates that the domain is not in the aligned region.

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