DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG13025 and RFWD3

DIOPT Version :9

Sequence 1:NP_001261971.1 Gene:CG13025 / 39874 FlyBaseID:FBgn0036660 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_001357463.1 Gene:RFWD3 / 55159 HGNCID:25539 Length:774 Species:Homo sapiens


Alignment Length:630 Identity:171/630 - (27%)
Similarity:275/630 - (43%) Gaps:70/630 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LDPEVYADETSTD-DSSGDDEVILNPV-EGLQPAVEIDEQRDQPGENAEPEQPRVPPLILVDPPH 70
            ||.......|..| .::..|....||| |.||.:...|...|...|...          :||   
Human   178 LDAYFQVSRTQPDLPATTYDSETRNPVSEELQVSSSSDSDSDSSAEYGG----------VVD--- 229

  Fly    71 LPSPPRNSRRNQGEEQEVISLETPSPPKKRKRLSAAAD--KSLKKSP---EGKPIVVD---DEDD 127
                       |.||...:.||........::.....|  |:|.|.|   :.:|::..   ||::
Human   230 -----------QAEESGAVILEEQLAGVSAEQEVTCIDGGKTLPKQPSPQKSEPLLPSASMDEEE 283

  Fly   128 GMTCPICLDSWEMSGEHRLVSLRCGHLFGESCIRRWLNESHRQSSVKVCPQCKTKATFRDIRHLY 192
            |.||.|||:.|..:|:|||.:||||||||..||..||     :..|:.||||..||...||..||
Human   284 GDTCTICLEQWTNAGDHRLSALRCGHLFGYRCISTWL-----KGQVRKCPQCNKKARHSDIVVLY 343

  Fly   193 AKRIQMLDTDIREQLEAERRRTHTL----TTELATAKLANTLTTEKLILLQKDYERLKELV---- 249
            |:.::.|||..:|::::...:...|    ..|.|..:|...:.|:|...||:..:.|::|.    
Human   344 ARTLRALDTSEQERMKSSLLKEQMLRKQAELESAQCRLQLQVLTDKCTRLQRRVQDLQKLTSHQS 408

  Fly   250 -RAGGGRGAFGGDASGQKSIQQLATYRLYMEKNFEITRDPGCRVLLYSAKHSMLVASQKSAQNLF 313
             .....||:.....|...|.|....::.:.:|.|.:::...||::.|....|.||.||.|.|..|
Human   409 QNLQQPRGSQAWVLSCSPSSQGQHKHKYHFQKTFTVSQAGNCRIMAYCDALSCLVISQPSPQASF 473

  Fly   314 -PGYGVRFIDPPTFKPLQFLHTSALLIRDIAFSD-SQHLLTVASRELKIKIFDIRTRLCSSMFTA 376
             ||:||:.:.....|..|::......||.:|||. .:.||..||.:..||:..:.|......:.|
Human   474 LPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 538

  Fly   377 HDKMLWSCALDRNEREHFLYGGDLRGGVYIYDLRFPENILCEFQAEVNLSPVIHIA--PVQPNKI 439
             .:.:|||....:| .:::|.|...|.:.:||:|...:.:.|..|:....|::.::  |...:..
Human   539 -GRPVWSCCWCLDE-ANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAA 601

  Fly   440 FTSGGFLVCQLTALTFYEYAAASDTAVPTRLNVE-GPFLSMQYDAVQDTVLISARSNPNFPQSRF 503
            |..||.|...|...:|:| .....:..|..|.:| |..:..|.:......|::.|.:.|....|.
Human   602 FPYGGVLAGTLEDASFWE-QKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRS 665

  Fly   504 ILGRMD-KID--GTPVLKVKA--TIYGSKATPVMTR------PTQLAVEDNTLVVGYLQDSKQLM 557
            :|..|. ::|  |.|:...:.  |.:|.....::|:      |..   :.|.||....:.:...:
Human   666 VLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPEN---DGNILVCTGDEAANSAL 727

  Fly   558 MHDVRREERVQTMPVNEVIYDICPVATQAGSYLAALTDNKCRVYK 602
            :.|......:|.:..::.:.||||......||||.||:....:||
Human   728 LWDAASGSLLQDLQTDQPVLDICPFEVNRNSYLATLTEKMVHIYK 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13025NP_001261971.1 zf-RING_2 130..180 CDD:290367 26/49 (53%)
WD40 <293..445 CDD:295369 44/155 (28%)
WD40 <318..>415 CDD:225201 26/97 (27%)
WD40 repeat 339..375 CDD:293791 12/36 (33%)
RFWD3NP_001357463.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..225 14/46 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..280 5/22 (23%)
mRING-C3HGC3_RFWD3 283..331 CDD:319364 27/52 (52%)
WD40 <486..774 CDD:225201 71/293 (24%)
WD 1 495..537 12/41 (29%)
WD40 repeat 500..537 CDD:293791 12/36 (33%)
WD 2 539..577 10/38 (26%)
WD40 repeat 543..580 CDD:293791 11/37 (30%)
WD 3 583..628 9/45 (20%)
WD40 repeat 588..655 CDD:293791 14/67 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146163
Domainoid 1 1.000 119 1.000 Domainoid score I5814
eggNOG 1 0.900 - - E1_KOG1645
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41230
Inparanoid 1 1.050 188 1.000 Inparanoid score I3926
Isobase 1 0.950 - 0 Normalized mean entropy S7722
OMA 1 1.010 - - QHG49616
OrthoDB 1 1.010 - - D1451258at2759
OrthoFinder 1 1.000 - - FOG0007495
OrthoInspector 1 1.000 - - oto90878
orthoMCL 1 0.900 - - OOG6_104706
Panther 1 1.100 - - LDO PTHR16047
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5303
SonicParanoid 1 1.000 - - X6377
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

Return to query results.
Submit another query.