DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13025 and rfwd3

DIOPT Version :9

Sequence 1:	NP_001261971.1	Gene:	CG13025 / 39874	FlyBaseID:	FBgn0036660	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_017948850.2	Gene:	rfwd3 / 100492921	XenbaseID:	XB-GENE-6041816	Length:	752	Species:	Xenopus tropicalis

Alignment Length:	659	Identity:	178/659 - (27%)
Similarity:	277/659 - (42%)	Gaps:	105/659 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NETEALDP-----------EVYADETSTDDSSGDDEVILNPVEGLQPAVEIDEQRDQPG--ENAE 54
            |.|:.|.|           ...|..||...||.:...:....||::.:.::||.....|  ..||
Frog   138 NRTQGLAPTSERVERNALLRTEATRTSPGGSSDETVELSEEEEGIESSTDVDEVEINAGAAPPAE 202

  Fly    55 P--------------EQPRVPPLILVDPPHLPSPPRNSRRNQGEEQEVISLETPSPPKKRKRLSA 105
            |              |.|.|..|:.|  |...:.|..::..|         :||.     |:||.
Frog   203 PAPEELQINVVEVQAEAPAVSNLVTV--PESVTLPLQTQTKQ---------KTPV-----KQLSP 251

  Fly   106 AADKSLKKSPEGKPIVVDDEDDGMTCPICLDSWEMSGEHRLVSLRCGHLFGESCIRRWLNESHRQ 170
            .  |:|  .||        ||:|.||.||.:.|..:|:|||.:||||||||.:||.|||     :
Frog   252 V--KTL--PPE--------EDEGDTCAICFEPWTNAGQHRLSALRCGHLFGFTCIERWL-----K 299

  Fly   171 SSVKVCPQCKTKATFRDIRHLYAKRIQMLDTDIREQ----LEAERRRTHTLTTELATAKLANTLT 231
            .....||||..||...||..|||:.::.|||..:|:    ||.|:........|.|..:|...:.
Frog   300 GGAAKCPQCNKKAKRADIVVLYARSLKALDTSEQERMKSSLEKEQSMRRKAELESAQCRLQVQVL 364

  Fly   232 TEKLILLQKDYERLKELV---------RAGGGRGAFGGDASGQKSIQQLATYRLYMEKNFEITRD 287
            |::...|:|..:.||.|:         :|...|....|..|..:     ..::...||...|::.
Frog   365 TDECGKLRKQIQELKMLIAQHGASTSMQASSSRSTISGSLSSSQ-----GQHKYNFEKAILISQA 424

  Fly   288 PGCRVLLYSAKHSMLVASQKSAQ-NLFPGYGVRFIDPPTFKPLQFLHTSALLIRDIAFSD-SQHL 350
            ..|||:.|....|.||.||.|.| .|.||.|::.:.....|..|::...:..||.:|||: |..|
Frog   425 GSCRVMSYCESMSCLVVSQPSPQTTLIPGCGIKKLSAANLKSSQYVPIHSKQIRGLAFSNRSDGL 489

  Fly   351 LTVASRELKIKIFDIRTRLCSSMFTAHDKMLWSCALDRNEREHFLYGGDLRGGVYIYDLRFPENI 415
            |..|:.:..||:..:.|......:.. .:.:|||.. .::..:::|.|.:.|.|.:||||...:.
Frog   490 LLSAALDNTIKLTSLLTNTVVQTYNT-GRPVWSCCW-CSDNSNYVYAGLINGSVLVYDLRDTSDC 552

  Fly   416 LCEFQAEVNLSPVIHIA--PVQPNKIFTSGGFLVCQLTALTFYEYAAASDTAVPTRLNVE-GPFL 477
            :.|.....:..||:.::  |...:::|..||.||..|....|:|  ...|...|..|.:| |...
Frog   553 VRELVPLGSRCPVVSLSYVPRAASEVFPCGGVLVGTLEGACFWE--MKDDQYRPHVLPLEPGGCT 615

  Fly   478 SMQYDAVQDTVLISARSNPNFPQSRFILGRMDKIDGTPVLKVKATIYGSKATPVMT--------R 534
            .:|.::.....|::.|....   ..::.|.|.::.... |......|.....||.|        .
Frog   616 DIQTESSTRHCLVTYRPGKT---HNYVRGVMMELTSNR-LSDSENEYSCSCYPVQTFNAGSTCKL 676

  Fly   535 PTQLAV------EDNTLVVGYLQDSKQLMMHDVRREERVQTMPVNEVIYDICPVATQAGSYLAAL 593
            .|:.|:      :.:.||....:.|...|:........:|.:..::.:.||||:.....|.||.|
Frog   677 LTKNAIFQSPERDGSILVCAGDEASNSAMLWHSGNGTLLQKLQADQPVLDICPMEVNQSSMLATL 741

  Fly   594 TDNKCRVYK 602
            |:...::||
Frog   742 TEKMVKIYK 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13025	NP_001261971.1	zf-RING_2	130..180	CDD:290367	25/49 (51%)
		WD40	<293..445	CDD:295369	43/155 (28%)
		WD40	<318..>415	CDD:225201	25/97 (26%)
		WD40 repeat	339..375	CDD:293791	12/36 (33%)
rfwd3	XP_017948850.2	mRING-C3HGC3_RFWD3	261..309	CDD:319364	26/52 (50%)
		WD40	<473..572	CDD:421866	26/100 (26%)
		WD40 repeat	477..514	CDD:293791	12/36 (33%)
		WD40 repeat	520..558	CDD:293791	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6305
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41230
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3888
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451258at2759
OrthoFinder	1	1.000	-	-		FOG0007495
OrthoInspector	1	1.000	-	-		oto104664
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060