Protein Alignment Nrt and CES2

DIOPT Version :9

• Sequence 1: NP_001189121.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 160/600 - (26%)
• Similarity: 223/600 - (37%)
• Gaps: 163/600 - (27%)

  Fly   311 LLTRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEG--V 373
            |..||....|.          ||.:|:.|       ....::.|:|       .|..|.|.|  |
Human     6 LRARLSAVACG----------LLLLLVRG-------QGQDSASPIR-------TTHTGQVLGSLV 46

  Fly   374 KEDGAFA----FRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLG------- 427
            ...||.|    |.|||:||||:..||:.|.|..:.    |:..........:|.|.|.
Human    47 HVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPES----WSGVRDGTTHPAMCLQDLTAVESEFL 107

  Fly   428 ---NGTTVGD---EDCLYLDVVTP-HVRYNNPLPVVVLIGAESLAGPSPGILRPSARYSRS---- 481
               |.|...|   ||||||.:.|| |....:.|||:|.|...:|      :...::.|..|
Human   108 SQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGAL------VFGMASLYDGSMLAA 166

  Fly   482 -HDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLL 545
             .:|:.|...:||||.||.:    |.:.|  .:||:...|.:|.|.|::.||.||||:|..||:.
Human   167 LENVVVVIIQYRLGVLGFFS----TGDKH--ATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIF 225

  Fly   546 GHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECAD-------I 603
            |..||.|.|:.||.|...:||:..|...||.|:|||. ::.|......::|.|...|       :
Human   226 GESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGL-IASSADVISTVVANLSACDQVDSEALV 289

  Fly   604 QCLREASSERLWAAT-PDTWLHFPVD---LPQ-PQEANAS-------------GSRHEWLVLDGD 650
            .|||..|.|.:.|.. |...:...||   ||: |||..||             .:...||:....
Human   290 GCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVM 354

  Fly   651 VVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLREL------HANWTREEVRAYL-ENSQIGA 708
            .::    ||.|.          |...|.:|..:|:..|      ..:..|||   |: :|.....
Human   355 RIY----DTQKE----------MDREASQAALQKMLTLLMLPPTFGDLLREE---YIGDNGDPQT 402

  Fly   709 LGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPS-VPFYVVTQGEGPDQLATV----- 767
            |              .|....:::|...|.|.|..|..|.| .|.|.......|..|..:
Human   403 L--------------QAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHM 453

  Fly   768 DADVQAIL---------GRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQP 823
            .||....|         |.|...|.|:.:....|.:.:..:..:|            |...:..|
Human   454 KADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNG------------NPNGEGLP 506

  Fly   824 -------EEDYLPCN 831
                   ||.||..|
Human   507 HWPLFDQEEQYLQLN 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	149/548 (27%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	151/558 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910