Protein Alignment Nrt and NLGN2

DIOPT Version :9

• Sequence 1: NP_001189121.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 142/570 - (24%)
• Similarity: 209/570 - (36%)
• Gaps: 162/570 - (28%)

  Fly   355 LREGRYIMAVTGCGPVEGVKED-------GAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDT 412
            |.|.|:.:..|..|.|.||:.:       ....|.|:|||.||:...|::|.|    ....|...
Human    36 LGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPE----APASWPGV 96

  Fly   413 LQTHNSSVVCTQRL------------------GNGTTVGD--EDCLYLDVVTP------------ 445
            .........|.|.|                  ...|.|.:  ||||||::..|
Human    97 RNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDE 161

  Fly   446 --------HVRYNNPLPVVVLI-GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLAL 501
                    .:|.....||::.: |...:.|  .|.:...:..:...:||....|:||||.|||:.
Human   162 ATLNPPDTDIRDPGKKPVMLFLHGGSYMEG--TGNMFDGSVLAAYGNVIVATLNYRLGVLGFLST 224

  Fly   502 -DALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKG 565
             |...|       |||.|.|.|..|.|:..||.||||||:.:|:.|..|||:.|.||:.|...:|
Human   225 GDQAAK-------GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEG 282

  Fly   566 LYTRAWASSGSAILPGKPLSESGKQNEQLMATLEC------ADIQCLREASSERLWAATPDTWLH 624
            |:.:|.|.||:||.......:..|....|.|.:.|      ..::|||...|..|
Human   283 LFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSREL---------- 337

  Fly   625 FPVDLP-QPQEAN-ASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLV-----MGATAHEAHT 682
              ||.. ||...: |.|.     |:|||||.:.|....::.:..:..:|:     .|....|...
Human   338 --VDQDVQPARYHIAFGP-----VVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSA 395

  Fly   683 EKLRELHANWTREEVRAYLENSQIGALGLTD------EVIEKYNASSYA----------SLVSII 731
            |....:.|:.....|..:::|    ..|..:      |.| |:..:.:|          :|:::.
Human   396 ESEDGVSASAFDFTVSNFVDN----LYGYPEGKDVLRETI-KFMYTDWADRDNGEMRRKTLLALF 455

  Fly   732 SDIRSVCPLLTNAR-----QQP--SVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFV 789
            :|.:.|.|.:..|:     |.|  ...||...|.||..:.|  ||
Human   456 TDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWA--DA-------------------- 498

  Fly   790 SAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIV 839
                       :||....:|       .|.......|..|||:  ||:.|
Human   499 -----------AHGDELPYV-------FGVPMVGATDLFPCNF--SKNDV 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	135/554 (24%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	139/565 (25%)
		Aes	<170..>268	CDD:223730	37/106 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900