DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and cel.2

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	601	Identity:	151/601 - (25%)
Similarity:	227/601 - (37%)	Gaps:	152/601 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 LIVFGILL-FVLLLGV-----IGYVLTHETLTSPPLREGRYIMAVTGCGPVEGVKEDGAF----- 379
            :::.|:.: ..|.||.     :|.|||          ||         |.|:|.......
Zfish     2 MMMLGVFISAALFLGTAQGASLGAVLT----------EG---------GMVQGKSHSVGLLRYMD 47

  Fly   380 AFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQ-RLGNGTTVGDEDCLYLDVV 443
            .|:|||:|.|| .||: ||..     :..|...|:....|..|.| .|....|:|.||||||::.
Zfish    48 VFKGIPFAAPP-GRLQ-KPVP-----HPGWEGVLKATEYSKRCIQLNLLQTDTMGSEDCLYLNIW 105

  Fly   444 TPH---VRYNNPLPVVVLI-GAESLAGPSPG------ILRPSARYSRSHDVIFVRPNFRLGVFGF 498
            .|.   |.||  |||:|.| |...|.|...|      .|......:...:||.|..|:|:|..||
Zfish   106 VPQGKTVSYN--LPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGNVIVVTFNYRVGSMGF 168

  Fly   499 LALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKV 563
            |:    |.:|..|  |||.|.|..|.::|:..||..|||:|.::|:.|..||:|.|...:.|.|.
Zfish   169 LS----TGDADAP--GNYGLWDQHAAISWVHRNIKAFGGNPDNITIFGESAGSTSVNFQIISPKN 227

  Fly   564 KGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECAD----IQCLRE--------ASSERLWA 616
            |||..||.:.||.|:.|........|..|::...:.|..    :.|||.        |...||..
Zfish   228 KGLIRRAISQSGVALCPWAINRNPRKFAEEIAKKVGCPTDSGMVACLRRTDPKAVTLAGKVRLAT 292

  Fly   617 ATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAH 681
            :..:..:|.....|               |:|||.:.:.|...:......|   .:.|....:.|
Zfish   293 SATEPIVHNLYLSP---------------VIDGDFIPDEPDTLFGNAADID---YIAGVNDMDGH 339

  Fly   682 ------TEKLRELHANWTREEVRAYL-----ENSQIGALGLTDEVIEKYNASS-----YASLVSI 730
                  ...:....|..|.|||:|..     :..|...:....|....:.:..     ..::|.:
Zfish   340 IFATLDIPSINNALATTTEEEVQALATALSKDRGQDAGIATFQEYTVNWGSKPNKEDIKKTVVEM 404

  Fly   731 ISDIRSVCPLLT-------NAR----------QQPSVPFYVVTQG-EGPDQLATVDADVQAILGR 777
            .:|...:.|..|       ||:          :...:|.:.:..| :..|:|       |.:.|:
Zfish   405 ETDYIFLVPTQTALYLHSDNAKSARTYSYLFSESSRIPIFPLWMGADHADEL-------QYVFGK 462

  Fly   778 YEPHTV-----EQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQD---------AQPEEDYL 828
              |.|.     .:.|.||.      |.:::.|  :|.|.... |.|:.         :.|...||
Zfish   463 --PFTTPLGYFPRHRDVSK------YMIAYWT--NFAQTGNP-NTGESKVPVTWPEFSNPGHQYL 516

  Fly   829 PCNYWISKDIVPRYAR 844
            ..|..|:.:.|.:..|
Zfish   517 DINNKINTNSVKKMLR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	137/545 (25%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	146/577 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900