DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and ces2b

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	550	Identity:	142/550 - (25%)
Similarity:	206/550 - (37%)	Gaps:	170/550 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 TGCGPVEGV------KEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCT 423
            |..|.::|:      |:....::.|||:|||||..||..|.:..:.    |..........::|.
Zfish    33 TNSGALKGLQMKARGKDTVIHSYLGIPFAKPPVGPLRLAPPQPAEK----WEGVRDATKQPLMCL 93

  Fly   424 Q----------RLGNGTTVGD--EDCLYLDVVTP-HVRYNNPLPVVVLIGAESLAGPSPGILRPS 475
            |          .|.....:.|  ||||||:|.|| ....|:.|||:|.|       ...|....|
Zfish    94 QDRQLVEDLVANLSAKVDMVDSSEDCLYLNVYTPSKPGRNDKLPVMVWI-------HGGGFTTCS 151

  Fly   476 ARYSRSH------DVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVH 534
            |.....|      ||:.|...:|||:.||.:    |.:.:.|  |||.|.|.:|.|.|::.||..
Zfish   152 ASLFDGHVLAAYQDVVVVVIQYRLGLLGFFS----TGDENAP--GNYGLLDQVAALQWVQENIHS 210

  Fly   535 FGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGS----AILPGKPL-------SESG 588
            |||||.|||:.|..||...|:|.|.|.....|:.||.|.||:    ||:...||       :.||
Zfish   211 FGGDPGSVTIFGESAGGISVSLHVLSPLSANLFHRAIAESGTAAMEAIMNVNPLPIAQAIGNASG 275

  Fly   589 KQNEQLMATLECADIQCLREASSERLWAATPDTWL-HFPVDLPQPQEANASGSRHEWLVLDGDVV 652
            .   .:.:|.:..|  ||.:.|...:...|.:..| .|.|                  .:||..:
Zfish   276 C---DISSTKKIVD--CLMQKSEVEILKITMENPLFRFGV------------------TIDGQFL 317

  Fly   653 FEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIE 717
            ....::.::.:|.|..|::.                                     |:||:.|
Zfish   318 PRPAAELFQSQQFNKVPLMT-------------------------------------GVTDDEI- 344

  Fly   718 KYNASSYASLVSIIS--DIRSVCPLLT---NARQQPSVPFYVVTQ--GEGPD------------- 762
            .:...:|......|:  |:.|:.||||   .|.|..||...::.:  |..||
Zfish   345 GFVLPNYLLPPDWINGLDLESILPLLTVFNPALQDQSVLELLLNEYLGTSPDRIRIRDGFREMLG 409

  Fly   763 ---------QLATVDADVQAILGRYE---PHTVEQRRFVS--------AMQQLFYYYVSHGTVQS 807
                     |.|:...|..|.:..||   |.:|.||:..|        .:..:|.|..|.|.
Zfish   410 DFMFNIPARQTASYHRDAGAPVYVYEFRHPPSVLQRKRPSFSGSDHGDEIVFVFGYCFSEGP--- 471

  Fly   808 FVQNRRVINVGQDAQPEEDYLPCN----YW 833
                   |.:.::...|||.| |.    ||
Zfish   472 -------IGMAENLSDEEDEL-CRTTMAYW 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	140/547 (26%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	141/549 (26%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910