DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and NLGN3

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	408	Identity:	106/408 - (25%)
Similarity:	149/408 - (36%)	Gaps:	131/408 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LLLGVIGYVLTHETLTSPP--------LREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVD 392
            |.|..:...|...|....|        ||..|..:.....|||:        .:.|:|||.||:.
Human    24 LTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVD--------QYLGVPYAAPPIG 80

  Fly   393 RLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRL--------------GNGTTVG------DEDC 437
            ..|:.|.|....    |:......:...||.|.:              .|...|.      :|||
Human    81 EKRFLPPEPPPS----WSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDC 141

  Fly   438 LYLDVVTP-------------------------------------------HVRYNNPLPVVVLI 459
            |||:|..|                                           .:|.:...||:|.|
Human   142 LYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYI 206

  Fly   460 GAESLAGPSPGILRPS--ARYSRSHDVIFVRPNFRLGVFGFLAL-DALTKEAHPPTSGNYALTDI 521
            ...|....:..::..|  |.|.   :||.:..|:|:||.|||:. |...|       |||.|.|.
Human   207 HGGSYMEGTGNMIDGSILASYG---NVIVITLNYRVGVLGFLSTGDQAAK-------GNYGLLDQ 261

  Fly   522 IAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSE 586
            |..|.|:..||..|||||:.:|:.|...||:.|:||..|...:||:.||...||||:       .
Human   262 IQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSAL-------S 319

  Fly   587 SGKQNEQ------LMA------TLECAD-IQCLREASSERLWAATPDTWLHFPVDLPQPQEANAS 638
            |...|.|      |:|      .|:..| :.|||:.|::.|          ...|:...:...|.
Human   320 SWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKEL----------VEQDIQPARYHVAF 374

  Fly   639 GSRHEWLVLDGDVVFEHP 656
            |.     |:||||:.:.|
Human   375 GP-----VIDGDVIPDDP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	98/374 (26%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	103/396 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900