DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrt and Cesl1

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	141/598 - (23%)
Similarity:	240/598 - (40%)	Gaps:	121/598 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 TRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLRE-------GRYIMAVTGCGPV 370
            ||:|.   |:|.::....:.|..|.|..:...:.....:|||:.:       |:|       ..:
  Rat    21 TRVRD---SIDWSICPRKMCLRSLFLVSLATCVVCGNPSSPPVVDTMKGKVLGKY-------ASL 75

  Fly   371 EGVKEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGD- 434
            |||.:..| .|.|:|:||||:..||:.|.:..:.    |:....|.....:|:|....|..:.|
  Rat    76 EGVTQSVA-VFLGVPFAKPPLGSLRFAPPQPAEP----WSFVKNTTTYPPMCSQDATKGQRMNDL 135

  Fly   435 -------------EDCLYLDVVTP-HVRYNNPLPVVVLI--------GAESLAGPSPGILRPSAR 477
                         ||||||::.|| ....::.:||:|.|        ||.:..|.   :|
  Rat   136 LTNRKEKVHLQFSEDCLYLNIYTPADFTKDSRMPVMVWIHGGGLTQGGASTYDGQ---VL----- 192

  Fly   478 YSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSV 542
             |...:|:.|...:|||::||.:    |.:.|  :.||:...|.:|.|:|::.||.:|||||.||
  Rat   193 -SAYENVVVVAIQYRLGIWGFFS----TGDEH--SRGNWGHLDQVAALHWVQDNIANFGGDPGSV 250

  Fly   543 TLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILP---GKPLSESGKQNEQL---MATLECA 601
            |:.|..||...|::||.|...|.||.||.:.||..::.   .|.:..:.||...:   ..|....
  Rat   251 TIFGESAGGFSVSVLVLSPLSKNLYHRAISESGVVLITELFTKDVRPAAKQIADMAGCKTTTSAI 315

  Fly   602 DIQCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWL--VLDGDVVFEHPSDTWKREQ 664
            .:.|||:.:.|.|........|   :.|...::...|   :.:|  |:|..|:.:.|.:....:.
  Rat   316 IVHCLRQKTEEELLEIMEKMNL---IKLSSQRDTKES---YHFLSTVIDDVVLPKDPKEILAEKN 374

  Fly   665 ANDKPVLVMGATAHEAH---TEKLRELHANWTREEVRAYLENSQIGAL-GLTDEV----IEKYNA 721
            .|..|.:| |....|..   ...:|.:..:...::..|.:...:..:: |:.:::    ||||..
  Rat   375 FNTVPYIV-GINKQECGWLLPTMMRFVPPDVKLDKKMAIMLLEKFASIYGIPEDIIPVAIEKYRK 438

  Fly   722 SS------YASLVSIISDIRSVCP--LLTNARQQPSVPFYVVTQGEGP---------DQLATVDA 769
            .|      ...:::.|.|.....|  :::...:....|.||......|         |.:.....
  Rat   439 GSDDPIKIRDGILAFIGDALFCIPSVMVSRDHRDAGAPTYVYEYQYYPSFSSPQRPKDVVGDHAD 503

  Fly   770 DVQAILGR--YEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNY 832
            ||.::.|.  ......|:...:|.|...|:                 .|..::..|....||  :
  Rat   504 DVYSVFGAPILRDGASEEEIKLSKMVMKFW-----------------ANFARNGNPNGRGLP--H 549

  Fly   833 WISKDIVPRYARV 845
            |...|....|.::
  Rat   550 WPQYDQKEEYLQI 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	125/527 (24%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	133/559 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100