DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	139/530 - (26%)
Similarity:	206/530 - (38%)	Gaps:	130/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 LREGRYIMAVTGCGPVEGVK------EDGAFAFRGIPYAKPPVDRLRWK---PAELIDDINMCWN 410
            |..|..::..|..|.|.|::      ::..|||.|||||||||..||::   |.|       .|.
  Fly    27 LSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPE-------PWQ 84

  Fly   411 DTLQ-THNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLI--GAESLAGPSPGIL 472
            ..|. |.|.|....:.:..|...|.||||:|:|....::...||||:|.|  |.......|..|.
  Fly    85 GVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIY 149

  Fly   473 RPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGG 537
            .|.  |.....|:||..|:||...|||:|    |:......||..|.|.:..|.||..||.||.|
  Fly   150 SPD--YFMKKPVVFVAINYRLAALGFLSL----KDPKLDVPGNAGLKDQVMALRWISQNIAHFNG 208

  Fly   538 DPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILP-------------GKPLSESGK 589
            ||.::||:|..||:..|.:::.:::.:||:.:|...||.|:..             .:.|...|.
  Fly   209 DPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGD 273

  Fly   590 QNE-QLMATLE--CA--------DIQCLREASSERLWAATPDTWLHFPVDLPQPQEAN--ASGSR 641
            :.: .:::.|.  ||        |:..|.|..|..|:|..|         :.:|.|.:  ....|
  Fly   274 EKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGP---------VIEPYETDHCVVPKR 329

  Fly   642 HEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEK--------LRELHANWTREEVR 698
            |:.|:          |:.|    .||.||:|.|.:.....:.:        |:..| |....|||
  Fly   330 HKDLL----------SEAW----GNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFH-NILPREVR 379

  Fly   699 AYLENSQIGALGL-------------TDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSV 750
               |.|.:....|             ..|.:|.:.|.:..|...|..|....  :|......|..
  Fly   380 ---ETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRF--ILARQSYAPKT 439

  Fly   751 PFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFV-----------SAMQQLFYYYVSHGT 804
            |.|          |...|.|        .||..:.||.|           ..:..|||..::...
  Fly   440 PTY----------LYRFDFD--------SPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKL 486

  Fly   805 VQSFVQNRRV 814
            .:|.::.:.:
  Fly   487 DKSSMEYKTI 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	137/523 (26%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	137/525 (26%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	40/109 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810