DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	121/491 - (24%)
Similarity:	194/491 - (39%)	Gaps:	112/491 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 TGCGPVEGVKE-----DGAFAFRGIPYAKPPVDRLRWK---PAELIDDINMCWND---TLQTHNS 418
            |..||::|||.     ...|:|..||:|||||..||:|   |.|:..::..|.:.   .||.|..
  Fly    36 TTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQKHFV 100

  Fly   419 SVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLI--GAESLAGPSPGILRPSARYSRS 481
            ..:         |.|.||||||:|.|.::....|:||:|.|  |.......|.....|.  |...
  Fly   101 FEM---------TDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASRECYSPD--YLLR 154

  Fly   482 HDVIFVRPNFRLG-------------VF-----GFLALDALTKEAHPPTSGNYALTDIIAVLNWI 528
            .||:.:..|:|||             :|     |||.||  ..|...|  ||..|.|.:..|.|:
  Fly   155 EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLD--DPELDVP--GNAGLKDQVLALRWV 215

  Fly   529 KLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQ 593
            |.|...||||..::|:.|..||:..|..::.:::..||:.:|...||:.:.|
  Fly   216 KANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSP------------- 267

  Fly   594 LMATLECADIQCLREASSERLWAATPDTWLHFPVDLP-QPQEANASGSRHEWLVL---DGDVVFE 654
                                 ||.||..  ::|..|. |...|..:.:|..|..|   .|..:.:
  Fly   268 ---------------------WAVTPQR--NWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIK 309

  Fly   655 HPSDTWKREQANDK------PVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTD 713
            ...:....|:..::      ||:....|:|....:|..|:...       |:..|..:...|:::
  Fly   310 ANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRT-------AWSNNIPLIIGGVSN 367

  Fly   714 EVIEKYN-ASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGR 777
            |.:..|: ..:....::.:.|.|.|.|:..|..::.::      ..|..|||.      |...|.
  Fly   368 EGLLLYSETKTNPKCLNELDDCRFVVPIELNMDRESAL------CREYGDQLR------QCYYGD 420

  Fly   778 YEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRR 813
            ..|.......::..:...::::..:.||.|.:|..|
  Fly   421 KTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYAR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	121/491 (25%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	121/491 (25%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	39/127 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900