DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and Ces3a

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_941074.1	Gene:	Ces3a / 382053	MGIID:	102773	Length:	571	Species:	Mus musculus

Alignment Length:	482	Identity:	133/482 - (27%)
Similarity:	204/482 - (42%)	Gaps:	101/482 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 LLFVLLLGVIGYVLTHETLTSPPLR-EGRYIMAVTGCGPVEGVKEDGAF--AFRGIPYAKPPVDR 393
            ||.:....|||..:|...:.:|..| .||.:          |||:....  .|.|||:|:.|:..
Mouse    21 LLLIFPTTVIGPKVTQPEVDTPLGRVRGRQV----------GVKDTDRMVNVFLGIPFAQAPLGP 75

  Fly   394 LRW------KPAELIDD--IN--MCWNDTLQTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTP-HV 447
            ||:      :|.|.:.|  ||  ||..|..:..||.....:::.....  .||||.|::.:| .:
Mouse    76 LRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPI--SEDCLTLNIYSPTEI 138

  Fly   448 RYNNPLPVVVLI-GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPP 511
            ...:..||:|.| |...|.|.|..  ...:..:...||:.|...:|||:||||:    |.:.|.|
Mouse   139 TAGDKRPVMVWIHGGSLLVGSSTS--HDGSALAAYGDVVVVTVQYRLGIFGFLS----TGDKHMP 197

  Fly   512 TSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGS 576
              ||....|::|.|.|::.||..|||||..||:.|:.||..:|:.|:.|....||:.||.:.||.
Mouse   198 --GNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGV 260

  Fly   577 AILPGKPLSE--SGKQNEQLMATLECAD------IQCLREASSERLWAATPDTWLHFPVD---LP 630
            .|  .|.|.:  :..:.:....::.|..      :|||.:...:.| ....:..:.:.|:   .|
Mouse   261 VI--SKILEDLNAWSEAQNFANSVACGSASPAELVQCLLQKEGKDL-ITKKNVNISYTVNDSFFP 322

  Fly   631 Q-PQEANASG-----------SRHE--------WLVLDGDVVFEHPSDTWKREQANDKPVLVMGA 675
            | ||:..|:.           :.||        |.:||   ..||.|.....|  |.:|:|
Mouse   323 QRPQKLLANKQFPTVPYLLGVTNHEFGWLLLKFWNILD---KMEHLSQEDLLE--NSRPLL---- 378

  Fly   676 TAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPL 740
                ||.:...|:......|    ||:|.       :||     :|:.|| |..::.||..|.|.
Mouse   379 ----AHMQLPPEIMPTVIDE----YLDNG-------SDE-----SATRYA-LQELLGDITLVIPT 422

  Fly   741 LTNAR--QQPSVPFYVVTQGEGPDQLA 765
            |..::  |....|.::......|...|
Mouse   423 LIFSKYLQDAGCPVFLYEFQHTPSSFA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	123/451 (27%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	127/467 (27%)
		Aes	75..>245	CDD:223730	59/179 (33%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910