DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrt and Gli

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	139/571 - (24%)
Similarity:	210/571 - (36%)	Gaps:	163/571 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 RYIMAVTGCGPVEGVK-------EDGAF----------------AFRGIPYAKPPVDRLRWKPAE 400
            |.:...|..|.|:|.|       :..:|                .|.|||||.||....|:||..
  Fly   133 RDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPR 197

  Fly   401 LIDDINMCWNDTLQTHNSSVVCTQRLG-NGTTVG----DEDCLYLDVVTPHV------RYNNPLP 454
                ::..| ..||..:....|.|.:. .|.|.|    |||||||:|.:|..      :|    |
  Fly   198 ----VHRGW-QLLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKY----P 253

  Fly   455 VVVLI-GAESLAGPS---PGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGN 515
            |:|.| |.|.:.|.|   .|.:..|     .:||:.|..|:|||..|||:    |.:.:.|  ||
  Fly   254 VMVYIHGGEFIRGASNLFQGHILAS-----FYDVVVVTLNYRLGALGFLS----TGDENSP--GN 307

  Fly   516 YALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILP 580
            |.:.|....|.|:..||..|.||..|:||.|..||.....||:.:.:.:.:..|..|.||||:..
  Fly   308 YGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALAD 372

  Fly   581 GKPLSESGK-QNEQ--LMATLECAD------IQCLREASSERLWAATPDTWLHFPVDLPQPQEAN 636
            ...:.:..: ||..  |...|.|:.      :.|||...|.              .:|...:.:.
  Fly   373 WALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSF--------------YELGNAEFSP 423

  Fly   637 ASGSRHEWLVLDGDVVFEHPSDTW--------------------KREQANDKPVLVMGATAHE-- 679
            ..||.....|||.:  |..|.|.|                    :..:.|.....:.|.|..|
  Fly   424 QVGSFPWGPVLDHN--FTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAA 486

  Fly   680 ---AHTEKLR---ELHANWTREEVRAYL--ENSQIGALGLTDEVIEKY----------NASSYAS 726
               |..|.|.   ||...:..:::|.::  .|..:...|:.:.:  ||          |......
  Fly   487 FFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAI--KYIYTFWPDPNNNTIIRDQ 549

  Fly   727 LVSIISDIRSVCPL--LTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFV 789
            .::::||:....|:  :.....:..||.|:....      .||:| :.....|..||.:| |.|:
  Fly   550 YINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLN------TTVEA-LNLPQWRKYPHDIE-RYFL 606

  Fly   790 SA---MQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKD 837
            :.   |...|:                         |::::|..|.|...|
  Fly   607 TGAPFMDTEFF-------------------------PKKEHLQRNMWTDND 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	135/561 (24%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	138/570 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810