DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and CG5397

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	128/530 - (24%)
Similarity:	188/530 - (35%)	Gaps:	152/530 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 VEGVK--EDGAFAFRGIPYAKPPVDRLRW-KPA--ELIDDINM------CWNDTLQTHNSSVVCT 423
            |||.:  ..|.::|.|:.||:|||..||: :|.  .|..|.|.      |    :|.|..   ..
  Fly    63 VEGFRNPSTGIYSFLGMHYAEPPVGPLRYSRPVYKRLAGDFNATKHGPPC----IQPHPQ---FP 120

  Fly   424 QRLGNGTTVGDEDCLYLDVVTPHV-RYNNPLPVVVLIGAESLAGPSPGILR--PSARYSRS---- 481
            ||:     :||||||.|:|.||.: .....|||.|.|        .||..|  .:|:|..:
  Fly   121 QRI-----IGDEDCLLLNVYTPQMPDETTGLPVFVWI--------HPGGYRYGSAAQYDATPMAQ 172

  Fly   482 HDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLG 546
            ...|.|.|.:|||..|.:. |. ||:    ..||.|:.|:.|.|.|:...|.:|||:|:.|..:|
  Fly   173 RGAIVVAPQYRLGSLGIMG-DG-TKQ----FDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIG 231

  Fly   547 HRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECADI-------- 603
            |.:||.....|..|...:.    |....|...:.|..||:.....|.:.:..|.|.|
  Fly   232 HGSGAASAMYLSMSPTSRS----AGDVHGVVAMSGTALSQYAMDKEPVQSVQEVAKINGCPTGNE 292

  Fly   604 ----QCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLV--LDGDVVFE-------- 654
                .|||..|:|.:              :....:..........||  |.|:|.|:
  Fly   293 LEIVNCLRSKSAEDI--------------IKNDDKVQTERLAGRALVKGLTGNVGFQPHIESEDD 343

  Fly   655 ----------HPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGAL 709
                      .|....|....:..|:|. |.|.||.                           |.
  Fly   344 GRALPSLIVGEPEQQLKSSNFSGIPLLT-GVTKHET---------------------------AN 380

  Fly   710 GLTDEVIEKYNASSYASLVSIISDIRSVCPL-----LTNARQQPSVP------------FYVVTQ 757
            .:|.|.|||...|:...|.|:...:..:...     ||....:|.:|            .:.|.|
  Fly   381 SVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKPELPGLTSVLTPTLQDVWKVPQ 445

  Fly   758 GEGPDQL------ATVDA--DVQAILGRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRV 814
            ....||:      :|.|.  ::.|:|     .|....|...|....|.|..:.....:|::...:
  Fly   446 ALNVDQVLSKVVESTTDVLFNLPAVL-----TTQVWSRLAPAFMYSFEYNGTKSKGINFLKGLPI 505

  Fly   815 INVGQDAQPE 824
            ::.....:||
  Fly   506 VSETAHDKPE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	128/530 (24%)
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	128/530 (24%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	66/208 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000