DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrt and Ces4a

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	145/584 - (24%)
Similarity:	227/584 - (38%)	Gaps:	130/584 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 ILLFVLLLGVIGYVLTHETL--TSPPLREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDR 393
            :.|::::...:|.:.|.|.|  |...:.:|:.:.  .|..|:.        .|.|:|:::|||..
  Rat    16 LTLWLVVQTALGALHTKEPLLITKHGILQGKQVH--VGDTPIR--------VFLGVPFSQPPVGT 70

  Fly   394 LRWKPAELIDDINMCWNDTLQTHNSSVVCTQR-LGNGTTV------------GDEDCLYLDVVTP 445
            .|:.|.|    ..:.||...........|.|. .|..|::            ..||||||:|..|
  Rat    71 RRFAPPE----PPLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAP 131

  Fly   446 HVRYNNP-LPVVVLI-GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEA 508
            .:...:| |||:|.. |...|.| |......|...:|. .|:.|...:|||:.||.:    |..:
  Rat   132 VLAPGDPLLPVMVWFPGGAFLVG-SASTYEGSELAARG-KVVLVFLQYRLGILGFFS----TGNS 190

  Fly   509 HPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWAS 573
            |  ..||:.|.|.||.|.|::.||..|||||.||||.|..|||..|:.|:.|...:||:.:|.:.
  Rat   191 H--ARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQ 253

  Fly   574 SGSAIL----PGKPLSESGKQNEQLMATLECAD-------IQCLREASSERLWAATPDTWLHFPV 627
            ||:|:|    ...||..:.|     :|.|...|       ::||:...:|::...:.........
  Rat   254 SGTAVLKTFITHDPLKSAKK-----IAHLAGCDHNSTKIMVKCLKALPAEKVMLVSKKMTFFRAN 313

  Fly   628 DLPQPQEANASGSRHEWL---VLDGDVVFEHPSDTWKREQANDKPVLV-MGATAHEAHTEKLREL 688
            ....|::.       .|.   |:||.|..|.|.....|.|....|.|: :.:...|.....|.:|
  Rat   314 SHKDPKDI-------VWFLSPVVDGLVFPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKL 371

  Fly   689 HAN---WTREEVRAYLENSQIGALGLTDEVIEKYNASSYAS--------------LVSIISDIRS 736
            ..|   ..:..:...|.:..| .|.:|:|.|... |..|.|              |:.::.|...
  Rat   372 QLNQRIMNKNYITKLLWSCSI-LLNITEEQIPLV-AREYLSDAISHHDWKMFRNHLIDLVGDATF 434

  Fly   737 VCPLLTNAR--QQPSVPFY------------VVTQGEGPDQLATVDADVQAILGRYEPHTV---- 783
            |...|..||  :....|.|            |..:.:|.|.    ..::..:.|  .|.:.
  Rat   435 VYATLQAARYHRDAGSPVYLYEFKHHAPGIIVKPRSDGADH----GDELSYLFG--SPFSKGSSR 493

  Fly   784 -EQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIVPRYARVD 846
             |::.|  ::|.:.|:                .|......|.:..||  ||...|...:|.::|
  Rat   494 GEEKEF--SLQMMKYW----------------ANFAHTGDPNDRELP--YWPRFDKEEKYLQLD 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	133/535 (25%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	142/567 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910